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Mitoxantrone (CID 51082) - Compound BioActivity Data
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BioActivity Outcomes:
Active(92)
 
 
Inactive(124)
 
 
Inconclusive(96)
 
 
Unspecified(12)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
 
NR LBD ER(8)
 
 
 
 
HELICc(8)
 
 
NR LBD TR(7)
 
 
 
 
NR LBD AR(7)
 
 
 
 
BioAssay Types:
Confirmatory(224)
 
 
 
 
Summary(25)
 
 
 
 
Screening(21)
 
 
 
Literature(9)
 
 
 
 
BioActivity Types:
Potency(238)
 
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 263    Data Row: 324   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144203748]
Potency-Replicate_1 0.0072qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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2
[SID144203748]
Potency-Replicate_1 0.0101qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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3
[SID144203748]
Potency 0.0321qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID144203748]
Potency 0.036qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID124963581]
IC50 0.0509Inhibition of recombinant PIM1 (unknown origin) expressed in Escherichia coli BL21(DE3) after 1 hr by HTRF assay [AID729383, Type: Literature]Serine/threonine-protein kinase pim-1 [gi:83305339]
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6
[SID50106605]
Potency 0.0562qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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7
[SID26747571]
Potency 0.082qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID26747571]
Potency 0.1qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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9
[SID26747571]
Potency 0.1636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID50106605]
Potency 0.2818Validation screen for inhibitors of Lassa infection [AID463096, Type: confirmatory]
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11
[SID50106605]
Potency 0.2818qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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12
[SID26747571]
Potency 0.3162qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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13
[SID50106605]
Potency 0.3981qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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14
[SID144203748]
Potency-Replicate_1 0.5074qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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15
[SID144203748]
Potency-Replicate_1 0.5117qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144203748]
Ratio Potency (uM) 0.531711qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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17
[SID144203748]
Potency-Replicate_1 0.5693qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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18
[SID26747571]
Potency 0.7079qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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19
[SID50106605]
Potency 0.7079qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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20
[SID50106605]
Potency 0.7079qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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