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BioActivity Data for Compound Mitoxantrone (CID 51082)

BioActivity Outcomes:
Active(124)
 
 
Inactive(151)
 
 
Inconclusive(100)
 
 
Unspecified(25)
 
 
Top Targets:
HELICc(8)
 
 
NR LBD PPAR(8)
 
 
 
 
NR LBD ER(8)
 
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD TR(7)
 
 
 
 
BioAssay Types:
Confirmatory(262)
 
 
 
 
Screening(34)
 
 
 
Literature(32)
 
 
 
 
Summary(27)
 
 
 
 
BioAssay Categories:
In vitro(1)
 
 
In vivo(3)
 
 
 
Biochemical(4)
 
 
Toxicity(26)
 
 
 
 
ADME(4)
 
 
Cell-based(49)
 
 
 
 
 
Organism-base..(2)
 
 
BioActivity Types:
Potency(246)
 
 
 
 
IC50(27)
 
 
 
 
AC50(15)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 339    Data Row: 400   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID170465183]
IC50 0.001GSK3B-pretreated HCT116 viability from Cell TiterGlo-IC50 [AID1117339, Type: confirmatory]
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2
[SID124963581]
IC50 0.0024Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei 427 after 3 days by Alamar Blue assay [AID774653, Type: Literature]
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3
[SID170465183]
IC50 0.0031Decreased HeLa cell count-IC50 [AID1117347, Type: confirmatory]
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4
[SID170465183]
IC50 0.0044VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area decrease-IC50 [AID1117337, Type: confirmatory]
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5
[SID144203748]
Potency-Replicate_1 0.0072qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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6
[SID144203748]
Potency-Replicate_1 0.0101qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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7
[SID170465183]
IC50 0.01274VEGF stimulated ADSC/ECFC co-culture nuclear area decrease (viability)-IC50 [AID1117324, Type: confirmatory]
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8
[SID170465183]
IC50 0.0303nuclear beta catenin stimulation in WNT3A conditioned C2C12 cells-IC50 [AID1117325, Type: confirmatory]
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9
[SID144203748]
Potency 0.0321qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID144203748]
Potency 0.036qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID124963581]
IC50 0.0509Inhibition of recombinant PIM1 (unknown origin) expressed in Escherichia coli BL21(DE3) after 1 hr by HTRF assay [AID729383, Type: Literature]Serine/threonine-protein kinase pim-1 [gi:83305339]
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12
[SID50106605]
Potency 0.0562qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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13
[SID26747571]
Potency 0.082qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID124963581]
IC50 0.1Cytotoxicity against doxorubicin-sensitive human MCF7 cells under oxic condition assessed as growth inhibition after 74 hrs by sulforhodamine B assay [AID632891, Type: Literature]
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15
[SID124963581]
IC50 0.1Cytotoxicity against human LoVo cells under oxic condition assessed as growth inhibition after 74 hrs by sulforhodamine B assay [AID632889, Type: Literature]
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16
[SID26747571]
Potency 0.1qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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17
[SID26747571]
Potency 0.1636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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18
[SID50106605]
Potency 0.2818Validation screen for inhibitors of Lassa infection [AID463096, Type: confirmatory]
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19
[SID50106605]
Potency 0.2818qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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20
[SID26747571]
Potency 0.3162qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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