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CHEMBL3113470 (CID 51049631) - Compound BioActivity Data
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BioActivity Outcomes:
Active(16)
 
 
Inactive(8)
 
 
Unspecified(10)
 
 
Top Targets:
PAD(13)
 
 
 
 
PAD M(4)
 
 
 
BioAssay Types:
Literature(17)
 
 
 
 
Confirmatory(5)
 
 
 
BioActivity Types:
IC50(8)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 22    Data Row: 34   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID118043681]
Average IC50 [PAD3] 0.39Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 21 against PAD1-4 [AID588486_3, Type: confirmatory]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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2
[SID194139615]
IC50 0.39Inhibition of recombinant wild-type PAD3 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069620, Type: Literature]Protein-arginine deiminase type-3 [gi:56757696]
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3
[SID194139615]
EC50 0.4Cytotoxicity against mouse NIH/3T3 cells after 3 days by XTT-PMS assay [AID1069593, Type: Literature]
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4
[SID194139615]
IC50 0.56Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069619, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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5
[SID118043681]
Average IC50 [PAD4] 0.56Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 21 against PAD1-4 [AID588486_4, Type: confirmatory]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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6
[SID194139615]
IC50 1.55Inhibition of recombinant wild-type PAD2 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069621, Type: Literature]Protein-arginine deiminase type-2 [gi:7531171]
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7
[SID194139615]
EC50 1.6Cytotoxicity against human U2OS cells after 3 days by XTT-PMS assay [AID1069594, Type: Literature]
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8
[SID194139615]
IC50 2.27Inhibition of recombinant wild-type PAD1 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069622, Type: Literature]Protein-arginine deiminase type-1 [gi:56757695]
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9
[SID118043681]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_1, Type: other]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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10
[SID118043681]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 21 against PAD1-4 [AID588486, Type: confirmatory]
View
11
[SID118043681]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560, Type: other]
View
12
[SID118043681]
Late stage assay provider results from the probe development effort to identify inhibitors of Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to identify inhibitors of PAD4 [AID588559, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
View
13
[SID118043681]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_4, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
View
14
[SID118043681]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PAD4 [AID651627, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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15
[SID118043681]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_3, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
View
16
[SID118043681]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_2, Type: other]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
View
17
[SID194139615]
Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate assessed as residual activity at 10 uM preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay relative to control [AID1069623, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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18
[SID194139615]
Ratio of Kinact to Ki(app) for recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 10 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069608, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
View
19
[SID194139615]
Cytotoxicity against mouse NIH/3T3 cells assessed as cell viability at 10 uM after 3 days by XTT-PMS assay relative to control [AID1069595, Type: Literature]
View
20
[SID194139615]
Cytotoxicity against human U2OS cells assessed as cell viability at 10 uM after 3 days by XTT-PMS assay relative to control [AID1069596, Type: Literature]
View