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AGN-PC-0A1K61 (CID 51049628) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Inactive(4)
 
 
Unspecified(4)
 
 
Top Targets:
PAD(6)
 
 
 
 
PAD M(2)
 
 
 
BioAssay Types:
Literature(4)
 
 
Confirmatory(1)
 
 
BioActivity Types:
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 8    Data Row: 16   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_2, Type: other]
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2
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_3, Type: other]
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3
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_4, Type: other]
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4
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560, Type: other]
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5
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628, Type: other]
View
6
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_3, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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7
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to identify inhibitors of PAD4 [AID588559, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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8
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_4, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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9
[SID194160331]
Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate assessed as residual activity at 10 uM preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay relative to control [AID1069623, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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10
[SID194160331]
Inhibition of recombinant wild-type PAD2 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate assessed as residual activity at 10 uM preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay relative to control [AID1069625, Type: Literature]Protein-arginine deiminase type-2 [gi:7531171]
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11
[SID194160331]
Inhibition of recombinant wild-type PAD1 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate assessed as residual activity at 10 uM preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay relative to control [AID1069626, Type: Literature]Protein-arginine deiminase type-1 [gi:56757695]
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12
[SID194160331]
Inhibition of recombinant wild-type PAD3 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate assessed as residual activity at 10 uM preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay relative to control [AID1069624, Type: Literature]Protein-arginine deiminase type-3 [gi:56757696]
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13
[SID118043678]
Average IC50 5Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 18 against PAD4 [AID588423, Type: confirmatory]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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14
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_1, Type: other]
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15
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_1, Type: other]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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16
[SID118043678]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_2, Type: other]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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