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alpha-ketoglutaric acid (CID 51) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(523)
 
 
Inconclusive(8)
 
 
Unspecified(27)
 
 
Top Targets:
MFS(16)
 
 
NR LBD AR(16)
 
 
 
NR LBD ER(16)
 
 
NR LBD PPAR(15)
 
 
 
NR LBD GR(12)
 
 
BioAssay Types:
Confirmatory(402)
 
 
 
 
Literature(97)
 
 
 
 
 
Summary(39)
 
 
Screening(5)
 
 
BioActivity Types:
Potency(309)
 
 
 
Kd(7)
 
 
IC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 402    Data Row: 568   Total Pages: 29   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103651937]
Kd 0.9Binding affinity to human PHD2 by nondenaturing ESI-MS [AID446352, Type: Literature]Egl nine homolog 1 [gi:32129514]
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2
[SID103651937]
Kd 0.9Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature [AID446356, Type: Literature]Egl nine homolog 1 [gi:32129514]
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3
[SID103651937]
Kd 0.9Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by 1H-15N HSQC titration assay [AID721527, Type: Literature]Egl nine homolog 1 [gi:32129514]
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4
[SID103651937]
Kd 1Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature in presence of HIF1alpha (556-574) CODD fragment [AID446357, Type: Literature]Egl nine homolog 1 [gi:32129514]
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5
[SID103651937]
Kd 1.7Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperature [AID446354, Type: Literature]Egl nine homolog 1 [gi:32129514]
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6
[SID103651937]
Kd 2Binding affinity to human PHD2 catalytic domain (181 to 426) Zn2 expressed in Escherichia coli by 1H-15N HSQC titration assay [AID721526, Type: Literature]Egl nine homolog 1 [gi:32129514]
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7
[SID103651937]
Km 2Activity of HIF prolyl hydroxylase-2 [AID506732, Type: Literature]
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8
[SID103651937]
Kd 2.2Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperature [AID446355, Type: Literature]Egl nine homolog 1 [gi:32129514]
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9
[SID103651937]
Km 20Activity of collagen prolyl 4 hydroxylase-1 [AID506735, Type: Literature]
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10
[SID103651937]
Km 25Activity of FIH-1 [AID506734, Type: Literature]
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11
[SID103651937]
Km 17.8TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681575, Type: Literature]Solute carrier family 22 member 7 [gi:81871841]
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12
[SID103651937]
Km 55Activity of HIF prolyl hydroxylase-3 [AID506733, Type: Literature]
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13
[SID103651937]
Km 57Enzyme kinetic constant for Glutamate racemase and expressed as Km [AID74672, Type: confirmatory]
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14
[SID103651937]
Km 60Activity of HIF prolyl hydroxylase-1 [AID506731, Type: Literature]
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15
[SID103651937]
Km 200Binding affinity to Escherichia coli AspAT by Michaelis-Menten model [AID723880, Type: Literature]
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16
[SID103651937]
IC50 700TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681158, Type: Literature]Solute carrier family 22 member 2 [gi:81872789]
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17
[SID103651937]
IC50 740TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681159, Type: Literature]Solute carrier family 22 member 1 [gi:81872095]
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18
[SID103651937]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681362, Type: Literature]Solute carrier family 22 member 6 [gi:81886651]
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19
[SID103651937]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681371, Type: Literature]Solute carrier family 22 member 7 [gi:81879627]
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20
[SID103651937]
TP_TRANSPORTER: trans-stimulation in Xenopus laevis oocytes [AID678813, Type: Literature]Solute carrier family 22 member 8 [gi:74730587]
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