Bookmark and Share
alpha-ketoglutaric acid (CID 51) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(518)
 
 
Inconclusive(11)
 
 
Unspecified(27)
 
 
Top Targets:
NR LBD ER(16)
 
 
MFS(16)
 
 
NR LBD AR(16)
 
 
 
NR LBD PPAR(15)
 
 
 
NR LBD TR(12)
 
 
BioAssay Types:
Confirmatory(400)
 
 
 
Literature(79)
 
 
 
 
 
Summary(39)
 
 
Screening(5)
 
 
BioActivity Types:
Potency(307)
 
 
 
Kd(7)
 
 
IC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 401    Data Row: 566   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103651937]
Kd 0.9Binding affinity to human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by 1H-15N HSQC titration assay [AID721527, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
2
[SID103651937]
Kd 0.9Binding affinity to human PHD2 by nondenaturing ESI-MS [AID446352, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
3
[SID103651937]
Kd 0.9Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature [AID446356, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
4
[SID103651937]
Kd 1Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature in presence of HIF1alpha (556-574) CODD fragment [AID446357, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
5
[SID103651937]
Kd 1.7Binding affinity to human PHD2-Mn(II) using 100% H2O MQC spectrometer operated at 23 MHz at 313K temperature [AID446354, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
6
[SID103651937]
Kd 2Binding affinity to human PHD2 catalytic domain (181 to 426) Zn2 expressed in Escherichia coli by 1H-15N HSQC titration assay [AID721526, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
7
[SID103651937]
Km 2Activity of HIF prolyl hydroxylase-2 [AID506732, Type: Literature]
View
8
[SID103651937]
Kd 2.2Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 313K temperature [AID446355, Type: Literature]Egl nine homolog 1 [gi:32129514]
View
9
[SID103651937]
Km 20Activity of collagen prolyl 4 hydroxylase-1 [AID506735, Type: Literature]
View
10
[SID103651937]
Km 25Activity of FIH-1 [AID506734, Type: Literature]
View
11
[SID103651937]
Km 17.8TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681575, Type: other]Solute carrier family 22 member 7 [gi:81871841]
View
12
[SID103651937]
Km 55Activity of HIF prolyl hydroxylase-3 [AID506733, Type: Literature]
View
13
[SID103651937]
Km 57Enzyme kinetic constant for Glutamate racemase and expressed as Km [AID74672, Type: other]
View
14
[SID103651937]
Km 60Activity of HIF prolyl hydroxylase-1 [AID506731, Type: Literature]
View
15
[SID103651937]
Km 200Binding affinity to Escherichia coli AspAT by Michaelis-Menten model [AID723880, Type: Literature]
View
16
[SID103651937]
IC50 700TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681158, Type: other]Solute carrier family 22 member 2 [gi:81872789]
View
17
[SID103651937]
IC50 740TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681159, Type: other]Solute carrier family 22 member 1 [gi:81872095]
View
18
[SID103651937]
Binding affinity to Escherichia coli AspAT by Michaelis-Menten model relative to natural substrate alpha-ketoglutarate [AID723879, Type: Literature]
View
19
[SID103651937]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681371, Type: other]Solute carrier family 22 member 7 [gi:81879627]
View
20
[SID103651937]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681362, Type: other]Solute carrier family 22 member 6 [gi:81886651]
View
21
[SID103651937]
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes [AID681747, Type: other]Solute carrier family 22 member 6 [gi:81886651]
View
22
[SID103651937]
TP_TRANSPORTER: inhibition of PAH uptake (PAH: 20 uM, alpha-KG: 1000 uM) in OAT-expressing COS-7 cells [AID681016, Type: other]Solute carrier family 22 member 6 [gi:81901833]
View
23
[SID103651937]
TP_TRANSPORTER: transepithelial transport (basal to apical) in MDR1-expressing LLC-PK1 cells [AID679458, Type: other]Multidrug resistance protein 1 [gi:238054374]
View
24
[SID17389187]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
View
25
[SID103651937]
TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.010? uM, alphaKG: 500 uM) in OCTN2-expressing HEK293 cells [AID682287, Type: other]Solute carrier family 22 member 5 [gi:8928257]
View
26
[SID103651937]
TP_TRANSPORTER: inhibition of Carnitine uptake (Carnitine: 0.01 uM, alpha-KG: 500 uM) in OCTN2-expressing HEK293 cells [AID680526, Type: other]Solute carrier family 22 member 5 [gi:8928277]
View
27
[SID103651937]
TP_TRANSPORTER: trans-stimulation in Xenopus laevis oocytes [AID678813, Type: other]Solute carrier family 22 member 8 [gi:74730587]
View
28
[SID103651937]
TP_TRANSPORTER: uptake in OAT2-expressing EcR293 cells [AID678961, Type: other]Solute carrier family 22 member 7 [gi:74753520]
View
29
[SID103651937]
TP_TRANSPORTER: inhibition of PAH uptake (alpha-KG: 500 uM) in OAT2-expressing EcR293 cells [AID680952, Type: other]Solute carrier family 22 member 7 [gi:74753520]
View
30
[SID103651937]
Km TP_TRANSPORTER: uptake in OAT1-expressing HeLa cells [AID679321, Type: other]Solute carrier family 22 member 6 [gi:74762955]
View
31
[SID103651937]
TP_TRANSPORTER: inhibition of Urate uptake (Urate: 300 uM, alpha-KG: 2000 uM) in OAT1-expressing S2 cells [AID679388, Type: other]Solute carrier family 22 member 6 [gi:74762955]
View
32
[SID103651937]
TP_TRANSPORTER: inhibition of PAH uptake (alpha,-KG: 200 uM) in OAT1-expressing HeLa cells [AID679394, Type: other]Solute carrier family 22 member 6 [gi:74762955]
View
33
[SID103651937]
TP_TRANSPORTER: inhibition of PAH uptake (PAH: 50 uM, alpha-KG: 1000 uM) in Xenopus laevis oocytes [AID682054, Type: other]Solute carrier family 22 member 6 [gi:74762955]
View
34
[SID103651937]
Enzyme kinetic constant for Glutamate racemase and expressed as Kcat [AID74673, Type: other]
View
35
[SID103651937]
Ratio of kcat to that of KM was determined [AID233183, Type: other]
View
36
[SID103651937]
Inhibition of human recombinant PHD2 (181-426) expressed in Escherichia coli BL21 (DE3) by TR-FRET assay [AID349747, Type: Literature]
View
37
[SID4252672]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
View
38
[SID4252672]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_1, Type: Literature]
View
39
[SID4252672]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_2, Type: Literature]
View
40
[SID4252672]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_3, Type: Literature]
View
41
[SID4252672]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_4, Type: Literature]
View
42
[SID50105487]
Potency qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
View
43
[SID4252672]
Potency S16 Schwann cell viability assay (CellTiter-Glo assay) [AID624031, Type: confirmatory]
View
44
[SID4252672]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_57, Type: Literature]
View
45
[SID4252672]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_58, Type: Literature]
View
46
[SID4252672]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_59, Type: Literature]
View
47
[SID4252672]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_60, Type: Literature]
View
48
[SID4252672]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_61, Type: Literature]
View
49
[SID4252672]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
50
[SID4252672]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View