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ropinirole (CID 5095) - Compound BioActivity Data
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BioActivity Outcomes:
Active(43)
 
 
Inactive(377)
 
 
Inconclusive(23)
 
 
Unspecified(39)
 
 
Top Targets:
7tm 4(46)
 
 
 
 
 
p450(13)
 
 
 
NR LBD PPAR(8)
 
 
P53(7)
 
 
NR LBD ER(7)
 
 
BioAssay Types:
Confirmatory(289)
 
 
 
 
Literature(126)
 
 
 
 
 
Summary(24)
 
 
Screening(22)
 
 
 
BioActivity Types:
Potency(274)
 
 
 
 
EC50(14)
 
 
Ki(10)
 
 
IC50(7)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 370    Data Row: 482   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103181541]
EC50 0.00389Agonist activity at Rattus norvegicus (rat) dopamine D2/D3 receptor transfected in african green monkey COS7 cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 10 min [AID1093074, Type: confirmatory]D(3) dopamine receptor [gi:118211]
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2
[SID103181541]
EC50 0.00389Agonist activity at Rattus norvegicus (rat) dopamine D2/D3 receptor transfected in african green monkey COS7 cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 10 min [AID1093074, Type: confirmatory]D(2) dopamine receptor [gi:47117674]
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3
[SID103181541]
EC50 0.004Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation [AID310687, Type: Literature]D(3) dopamine receptor [gi:1169206]
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4
[SID103181541]
Ki 0.0072Binding affinity towards Dopamine receptor D2 by displacement of [3H]U-86170. [AID63977, Type: Literature]D(2) dopamine receptor [gi:118206]
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5
[SID103181541]
EC50 0.0103Agonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID461563, Type: Literature]D(3) dopamine receptor [gi:1169206]
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6
[SID103181541]
EC50 0.0103Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding [AID513742, Type: Literature]D(3) dopamine receptor [gi:1169206]
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7
[SID103181541]
Ki 0.019Binding affinity towards Dopamine receptor D3 by displacement of [3H](+)-7-OH-DPAT. [AID65774, Type: Literature]D(3) dopamine receptor [gi:1169206]
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8
[SID103181541]
EC50 0.0192Agonist activity at human dopamine D3 receptor expressed in mouse AtT-20 cells assessed as stimulation of [35S]GTPgamma binding [AID446402, Type: Literature]D(3) dopamine receptor [gi:1169206]
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9
[SID103181541]
Ki 0.0293Displacement of [3H]spiperone from rat D3 receptor expressed in HEK293 cells [AID513739, Type: Literature]D(3) dopamine receptor [gi:118211]
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10
[SID103181541]
Ki 0.0293Displacement of [3H]spiperone from rat cloned dopamine D3 receptor expressed in HEK293 cells after 1 hr [AID750046, Type: Literature]D(3) dopamine receptor [gi:118211]
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11
[SID103181541]
Ki 0.03631Displacement of [3H]spiperone form human cloned dopamine D3 receptor expressed in CHO cells [AID353683, Type: Literature]D(3) dopamine receptor [gi:1169206]
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12
[SID103181541]
IC50 0.0561Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting [AID1093079, Type: confirmatory]D(3) dopamine receptor [gi:118211]
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13
[SID103181541]
IC50 0.0561Displacement of [3H]nemonapride from Rattus norvegicus (rat) chimeric dopamine D3 trunk/D2 tail receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting [AID1093079, Type: confirmatory]D(2) dopamine receptor [gi:47117674]
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14
[SID103181541]
Ki 0.061Agonist activity at dopamine D3 receptor (unknown origin) [AID773370, Type: Literature]D(3) dopamine receptor [gi:1169206]
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15
[SID103181541]
EC50 0.0755Agonist activity at Rattus norvegicus (rat) dopamine D2 receptor transfected in african green monkey COS7 cells assessed as inhibition of forskolin-stimulated adenylyl cyclase activity after 10 min [AID1093075, Type: confirmatory]D(2) dopamine receptor [gi:47117674]
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16
[SID103181541]
EC50 0.083Agonist activity at human recombinant dopamine D2 receptor expressed in rat pituitary cells assessed as inhibition of forskolin-stimulated cAMP accumulation [AID310686, Type: Literature]D(2) dopamine receptor [gi:118206]
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17
[SID103181541]
EC50 0.1Inhibitory activity against constrictor response to electrical stimulation in the isolated perfused rabbit ear artery(REA) expressing dopamine receptor [AID62577, Type: Literature]
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18
[SID103181541]
EC50 0.1Ability to relax the electrically stimulated rabbit ear artery was determined [AID167274, Type: Literature]
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19
[SID103181541]
EC50 0.1Ability to stimulate peripheral prejunctional dopaminergic receptors by 50% inhibition of vasoconstrictor response to field stimulation in isolated perfused rabbit ear artery [AID167710, Type: Literature]
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20
[SID103181541]
IC50 0.107Displacement of [3H]nemonapride from Rattus norvegicus (rat) wild type dopamine D3 receptor transfected in african green monkey COS7 cells after 1 hr by beta scintillation counting [AID1093077, Type: confirmatory]D(3) dopamine receptor [gi:118211]
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