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CHEMBL3099769 (CID 50919376) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(4)
 
 
Unspecified(17)
 
 
Top Targets:
7tm 4(6)
 
 
 
BioAssay Types:
Literature(18)
 
 
 
Confirmatory(7)
 
 
 
BioActivity Types:
EC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 24    Data Row: 26   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID194138841]
EC50 2.3Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay [AID1061686, Type: Literature]Neurotensin receptor type 1 [gi:62297312]
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2
[SID113635345]
EC50_Mean 2.31SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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3
[SID126723248]
EC50_Mean 4.47SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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4
[SID113635345]
EC50_Mean 6.08SAR analysis of small molecule agonists of the NTR1 receptor via a luminescent beta-arrestin assay [AID602427, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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5
[SID113635345]
SAR analysis of small molecule agonists of the NTR1 receptor in a single concentration fluorescent-based calcium flux assay [AID602466, Type: other]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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6
[SID194138841]
LC50 50Cytotoxicity in human Fa2N-4 cells after 24 hrs [AID1061661, Type: Literature]
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7
[SID194138841]
Metabolic stability in mouse liver microsomes assessed as compound remaining at 1hr [AID1061662, Type: Literature]
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8
[SID194138841]
Metabolic stability in human liver microsomes assessed as compound remaining at 1 hr [AID1061663, Type: Literature]
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9
[SID194138841]
Metabolic stability in human plasma assessed as compound remaining at 3 hrs [AID1061664, Type: Literature]
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10
[SID194138841]
Metabolic stability in mouse plasma assessed as compound remaining at 3 hrs [AID1061665, Type: Literature]
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11
[SID194138841]
Plasma protein binding in mouse at 10 uM [AID1061666, Type: Literature]
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12
[SID194138841]
Plasma protein binding in human at 10 uM [AID1061667, Type: Literature]
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13
[SID194138841]
Plasma protein binding in mouse at 1 uM [AID1061668, Type: Literature]
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14
[SID194138841]
Blood brain permeability of the compound at donor and acceptor pH 7.4 by PAMPA [AID1061669, Type: Literature]
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15
[SID194138841]
Plasma protein binding in human at 1 uM [AID1061670, Type: Literature]
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16
[SID194138841]
Permeability of the compound at donor and acceptor pH 7.4 by PAMPA [AID1061673, Type: Literature]
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17
[SID194138841]
Permeability of the compound at donor pH 6.2 and acceptor pH 7.4 by PAMPA [AID1061674, Type: Literature]
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18
[SID194138841]
Permeability of the compound at donor pH 5.0 and acceptor pH 7.4 by PAMPA [AID1061675, Type: Literature]
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19
[SID194138841]
Aqueous solubility of the compound in pION buffer at pH 7.4 [AID1061676, Type: Literature]
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20
[SID194138841]
Aqueous solubility of the compound in pION buffer at pH 6.2 [AID1061677, Type: Literature]
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