Risperidone (CID 5073) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(197)
 
 
Top Targets:
7TM GPCR Srx(33)
 
 
7TM GPCR Srsx(12)
 
 
CAP ED(9)
 
 
DUF3353(1)
 
 
SLC6sbd SERT(1)
 
 
BioAssay Types:
Literature(150)
 
 
Confirmatory(18)
 
 
Screening(3)
 
 
BioActivity Types:
Ki(97)
 
 
IC50(51)
 
 
Potency(19)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 185    Data Row: 197   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103170825]
Ki 0.00014Ability to displace [3H]ketanserin from serotonergic 5-hydroxytryptamine 2 receptor [AID5258, Type: other]
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2
[SID103170825]
Ki 0.00015Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometry [AID410335, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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3
[SID103170825]
Ki 0.00015Displacement of [3H]ketanserin from 5HT2A receptor in CRL:CD(SD)BR-COBS rat cortex by scintillation spectrometry [AID410335, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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4
[SID103170825]
Ki 0.00016Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2A serotonin receptor. [AID5504, Type: Literature]
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5
[SID103170825]
Ki 0.00016Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptor [AID5197, Type: Literature]
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6
[SID103170825]
Ki 0.0002The binding affinity was measured on 5-hydroxytryptamine 2 receptor in rat brain tissue [AID5303, Type: Literature]
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7
[SID103170825]
Ki 0.0002Affinity for 5-hydroxytryptamine 2 receptor [AID5246, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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8
[SID103170825]
Ki 0.0002Affinity for 5-hydroxytryptamine 2 receptor [AID5246, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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9
[SID103170825]
Ki 0.00029Binding affinity to human cloned 5HT2A receptor [AID342784, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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10
[SID103170825]
Ki 0.00029Binding affinity to human cloned 5HT2A receptor [AID342784, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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11
[SID103170825]
Ki 0.00029Binding affinity to human cloned 5HT2A receptor [AID342784, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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12
[SID103170825]
Ki 0.00032The compound was measured at a dose 10 times the ED50 value for CAR block for production of catalepsy in the rat [AID184416, Type: Literature]
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13
[SID103170825]
IC50 0.000346DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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14
[SID103170825]
IC50 0.000346DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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15
[SID103170825]
IC50 0.000346DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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16
[SID103170825]
Ki 0.00039Binding affinity for human 5-hydroxytryptamine 2A receptor [AID5199, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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17
[SID103170825]
Ki 0.00039Binding affinity for human 5-hydroxytryptamine 2A receptor [AID5199, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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18
[SID103170825]
Ki 0.00039Binding affinity for human 5-hydroxytryptamine 2A receptor [AID5199, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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19
[SID103170825]
Ki 0.00044Binding affinity towards human D2 dopamine receptor. [AID63070, Type: Literature]
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20
[SID103170825]
Ki 0.000501Displacement of [3H]ketanserin from human cloned 5HT2A receptor [AID439066, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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21
[SID103170825]
Ki 0.000501Displacement of [3H]ketanserin from human cloned 5HT2A receptor [AID439066, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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22
[SID103170825]
Ki 0.000501Displacement of [3H]ketanserin from human cloned 5HT2A receptor [AID439066, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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23
[SID103170825]
Ki 0.00054Relative binding affinity for D2 receptor and 5-hydroxytryptamine 2A receptor, ratio of Ki [AID5573, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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24
[SID103170825]
Ki 0.00054Relative binding affinity for D2 receptor and 5-hydroxytryptamine 2A receptor, ratio of Ki [AID5573, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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25
[SID103170825]
Ki 0.00069Binding affinity towards human alpha-1 adrenergic receptor [AID36116, Type: Literature]
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26
[SID103170825]
Ki 0.0007Binding affinity measured at the 5-hydroxytryptamine 2A receptor by the inhibition of [3H]ketanserin binding to rat cortex using unlabeled mianserin for nonspecific binding. [AID5522, Type: Literature]
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27
[SID103170825]
Ki 0.00074Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in rat brain [AID35277, Type: Literature]Alpha-1B adrenergic receptor [gi:543734]
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28
[SID103170825]
Ki 0.00074Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in rat brain [AID35277, Type: Literature]Alpha-1B adrenergic receptor [gi:543734]
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29
[SID103170825]
IC50 0.00076Inhibition of [3H]ketanserin binding to dopamine 5-hydroxytryptamine 2 receptor [AID4812, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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30
[SID103170825]
IC50 0.00076Inhibition of [3H]ketanserin binding to dopamine 5-hydroxytryptamine 2 receptor [AID4812, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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31
[SID103170825]
Ki 0.00081Inhibition of [125I]R91150 binding to human 5-hydroxytryptamine 2A receptor [AID239010, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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32
[SID103170825]
Ki 0.00081Inhibition of [125I]R91150 binding to human 5-hydroxytryptamine 2A receptor [AID239010, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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33
[SID103170825]
Ki 0.00081Inhibition of [125I]R91150 binding to human 5-hydroxytryptamine 2A receptor [AID239010, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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34
[SID103170825]
Ki 0.00081Compound was evaluated for its binding affinity with Alpha-1 adrenergic receptor using membranes prepared from rat cerebral cortex [AID37475, Type: Literature]
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35
[SID103170825]
IC50 0.000989DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
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36
[SID103170825]
Ki 0.001The compound was tested against Alpha-1 adrenergic receptor for percent displacement of radioligand at 10e-6 M [AID36122, Type: Literature]
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37
[SID103170825]
Ki 0.0014Binding affinity towards rat 5-hydroxytryptamine 7 receptor [AID6648, Type: Literature]
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38
[SID103170825]
Ki 0.0014Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D2L in COS7 cells [AID64327, Type: Literature]
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39
[SID103170825]
IC50 0.0014Inhibition of [3H]ketanserin binding to rat frontal cortex membrane 5-hydroxytryptamine 2A receptor [AID5485, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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40
[SID103170825]
IC50 0.0014Inhibition of [3H]ketanserin binding to rat frontal cortex membrane 5-hydroxytryptamine 2A receptor [AID5485, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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41
[SID103170825]
IC50 0.0015Inhibitory activity against serotonin 5-hydroxytryptamine 2 receptor from mice. [AID5020, Type: Literature]
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42
[SID103170825]
Ki 0.0018Binding affinity towards human alpha-2 adrenergic receptor [AID36197, Type: Literature]
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43
[SID103170825]
Ki 0.0018Ability to displace [3H]spiperone from D2 dopamine receptor isolated from the striata of male Wistar rats [AID61337, Type: other]
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44
[SID103170825]
IC50 0.00195DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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45
[SID103170825]
IC50 0.00195DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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46
[SID103170825]
Ki 0.0021Affinity for Dopamine receptor D2 [AID65243, Type: Literature]D(2) dopamine receptor [gi:47117674]
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47
[SID103170825]
Ki 0.0022Binding affinity to human cloned dopamine D2 receptor [AID342777, Type: Literature]D(2) dopamine receptor [gi:118206]
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48
[SID103170825]
Ki 0.0022Binding affinity to human cloned dopamine D2 receptor [AID342777, Type: Literature]D(2) dopamine receptor [gi:118206]
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49
[SID103170825]
Ki 0.0022Binding affinity to human cloned dopamine D2 receptor [AID342777, Type: Literature]D(2) dopamine receptor [gi:118206]
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50
[SID103170825]
Ki 0.0022Binding affinity to human cloned dopamine D2 receptor [AID342777, Type: Literature]D(2) dopamine receptor [gi:118206]
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