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CHEMBL2203532 (CID 5019834) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(3)
 
 
Unspecified(2)
 
 
Top Targets:
STKc STK33(2)
 
 
14-3-3 gamma(1)
 
 
STKc PKA(1)
 
 
PKc like(1)
 
 
BioAssay Types:
Literature(3)
 
 
 
Confirmatory(3)
 
 
 
Screening(1)
 
 
BioActivity Types:
AC50(3)
 
 
 
IC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 7   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID125081983]
AC50_uM 0.977STK-33 Kinase Inhibition Measured in Biochemical System Using Plate Reader - 2052-02_Inhibitor_Dose_DryPowder_Activity_Set2 [AID588480, Type: confirmatory]serine/threonine-protein kinase 33 isoform a [Homo sapiens] [gi:23943882]
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2
[SID163321917]
IC50 0.98Inhibition of N-terminal 6His-tagged full length human recombinant STK33 using myelin basic protein as substrate incubated for 15 mins before initiation of kinase reaction measured after 1 hr by ADP-glo assay [AID712545, Type: Literature]Serine/threonine-protein kinase 33 [gi:74761329]
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3
[SID163321917]
IC50 10Inhibition of His-tagged recombinant catalytic fragment of PKA assessed as phosphorylation of fluorescent-labeled peptide 21substrate by caliper capillary electrophoresis [AID712541, Type: Literature]
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4
[SID163321917]
Selectivity ratio of IC50 for His-tagged recombinant catalytic fragment of PKA to IC50 for N-terminal 6His-tagged full length human recombinant STK33 [AID712544, Type: Literature]
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5
[SID125081983]
AC50_uM Counter screen for activity against Aurora B, in dose Measured in Biochemical System Using Scintillation - 2052-06_Inhibitor_Dose_DryPowder_Activity_Set3 [AID588808, Type: confirmatory]aurora kinase B isoform 1 [Homo sapiens] [gi:83776600]
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6
[SID125081983]
AC50_uM Protein Kinase A Activity Assay Measured in Biochemical System Using Plate Reader - 2052-04_Inhibitor_Dose_DryPowder_Activity_Set2 [AID588629, Type: confirmatory]cAMP-dependent protein kinase catalytic subunit alpha isoform 1 [Homo sapiens] [gi:4506055]
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7
[SID24357786]
HTS for 14-3-3 protein interaction modulators [AID422, Type: screening]14-3-3 protein gamma [Homo sapiens] [gi:21464101]
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