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N-{4-[1-(ethylsulfonyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl]phenyl}methanesulfonamide (CID 5019487) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(675)
 
 
Inconclusive(19)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(20)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(480)
 
 
 
 
Confirmatory(206)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(151)
 
 
 
 
IC50(41)
 
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 645    Data Row: 705   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17514390]
IC50 0.37007Fluorescence-based biochemical high throughput dose response assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID652135, Type: confirmatory]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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2
[SID17514390]
IC50 0.98Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluorescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) dose response assay to identify assay artifacts [AID652145, Type: confirmatory]
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3
[SID17514390]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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4
[SID17514390]
uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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5
[SID17514390]
Single concentration confirmation of uHTS inhibitor hits from RPN11 in a Fluorescence Polarization assay [AID602318, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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6
[SID17514390]
Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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7
[SID17514390]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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8
[SID17514390]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 Wildtype [AID1529, Type: screening]mitogen-activated protein kinase kinase kinase 3 isoform 1 [Homo sapiens] [gi:42794767]
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9
[SID17514390]
uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COP9 signalosome complex subunit 5 [Homo sapiens] [gi:38027923]
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10
[SID17514390]
Single concentration validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay [AID602333, Type: screening]TPA: prothrombin [Bos taurus] [gi:296479639]
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11
[SID17514390]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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12
[SID17514390]
Potency 35.4813qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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13
[SID17514390]
Potency 56.2341qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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14
[SID17514390]
IC50 Chemical Antagonists IAP-family anti-apoptotic proteins [AID1018, Type: confirmatory]X-linked inhibitor of apoptosis [Homo sapiens] [gi:8744934]
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15
[SID17514390]
Identification of VIF Inhibitors Measured in Cell-Based System Using Imaging - 2108-01_Inhibitor_SinglePoint_HTS_Activity [AID602346, Type: screening]Vif [Human immunodeficiency virus 1] [gi:9629361]
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16
[SID17514390]
TRFRET-based biochemical primary high throughput screening assay to identify small molecules that bind to the HIV-1-gp120 binding antibody, PG9 [AID624416, Type: screening]Envelope surface glycoprotein gp160, precursor [Human immunodeficiency virus 1] [gi:9629363]
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17
[SID17514390]
High Throughput Screen to Identify Compounds that Inhibit Class II HMG-CoA Reductases - Primary Screen [AID1066, Type: screening]acetyl-CoA acetyltransferase/HMG-CoA reductase [Enterococcus faecalis] [gi:9937384]
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18
[SID17514390]
Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for MLPCN Compound Set [AID602162, Type: screening]ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens] [gi:9955963]
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19
[SID17514390]
Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_SinglePoint_HTS_Activity [AID504414, Type: screening]Golgi-associated PDZ and coiled-coil motif-containing protein isoform a [Homo sapiens] [gi:9966877]
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20
[SID17514390]
qHTS for Agonists of the Human Mucolipin Transient Receptor Potential 1 (TRPML1) [AID624414, Type: screening]mucolipin-1 [Homo sapiens] [gi:10092597]
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21
[SID17514390]
qHTS for Inhibitors of the Human Mucolipin Transient Receptor Potential 1 (TRPML1) [AID624415, Type: screening]mucolipin-1 [Homo sapiens] [gi:10092597]
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22
[SID17514390]
Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao. [AID1415, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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23
[SID17514390]
Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. [AID1423, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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24
[SID17514390]
Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. [AID1439, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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25
[SID17514390]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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26
[SID17514390]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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27
[SID17514390]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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28
[SID17514390]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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29
[SID17514390]
Potency qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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30
[SID17514390]
Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary Assay [AID1020, Type: screening]glucose-6-phosphate dehydrogenase [Leuconostoc mesenteroides] [gi:149631]
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31
[SID17514390]
Potency qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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32
[SID17514390]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID758, Type: screening]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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33
[SID17514390]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
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34
[SID17514390]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae, specifically CIT2 Cherry Pick Compounds [AID2274, Type: screening]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
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35
[SID17514390]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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36
[SID17514390]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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37
[SID17514390]
Potency qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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38
[SID17514390]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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39
[SID17514390]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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40
[SID17514390]
Kallikrein 5 1536 HTS [AID873, Type: screening]kallikrein-5 preproprotein [Homo sapiens] [gi:6912644]
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41
[SID17514390]
Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity [AID504441, Type: screening]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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42
[SID17514390]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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43
[SID17514390]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624037, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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44
[SID17514390]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624038, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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45
[SID17514390]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human cholinergic receptor, muscarinic 5 (CHRM5) [AID624040, Type: screening]muscarinic acetylcholine receptor M5 [Homo sapiens] [gi:7108336]
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46
[SID17514390]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]interleukin-2 precursor [Mus musculus] [gi:7110653]
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47
[SID17514390]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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48
[SID17514390]
Primary biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase [AID1527, Type: screening]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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49
[SID17514390]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Mcl-1 [AID1009, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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50
[SID17514390]
uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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