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BioActivity Data for Compound quetiapine (CID 5002)

BioActivity Outcomes:
Active(99)
 
 
Inactive(806)
 
 
Inconclusive(34)
 
 
Unspecified(342)
 
 
Top Targets:
7tm 4(116)
 
 
 
 
p450(13)
 
 
 
 
NR LBD ER(9)
 
 
 
NR LBD PPAR(8)
 
 
 
NR LBD AR(8)
 
 
 
 
BioAssay Types:
Confirmatory(491)
 
 
 
 
 
Screening(384)
 
 
 
 
Literature(219)
 
 
 
 
 
Summary(24)
 
 
 
BioAssay Categories:
In vitro(140)
 
 
 
 
In vivo(139)
 
 
 
Biochemical(347)
 
 
 
 
 
Toxicity(167)
 
 
 
 
ADME(18)
 
 
Cell-based(230)
 
 
 
 
 
Organism-base..(12)
 
 
BioActivity Types:
Potency(322)
 
 
 
 
 
IC50(148)
 
 
 
 
Ki(66)
 
 
 
AC50(6)
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1076    Data Row: 1281   Total Pages: 65   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103195252]
Ki 0.0045Binding affinity towards human alpha-1 adrenergic receptor [AID36116, Type: Literature]
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2
[SID103195252]
Ki 0.0087Binding affinity to human cloned histamine H1 receptor [AID342782, Type: Literature]Histamine H1 receptor [gi:547645]
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3
[SID103195252]
Ki 0.01Binding affinity to H1 histamine receptor (unknown origin) by PDSP assay [AID1119695, Type: confirmatory]Histamine H1 receptor [gi:547645]
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4
[SID103195252]
Ki 0.019Binding affinity towards human histamine H1 receptor [AID87242, Type: Literature]
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5
[SID103195252]
Ki 0.021Binding affinity towards human H1 receptor [AID87244, Type: Literature]
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6
[SID103195252]
IC50 0.0245DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: confirmatory]Alpha-1B adrenergic receptor [gi:543734]
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7
[SID103195252]
IC50 0.0396DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: confirmatory]Histamine H1 receptor [gi:547645]
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8
[SID103195252]
IC50 0.04Displacement of [3H]mepyramine from H1R in rat brain [AID330561, Type: Literature]Histamine H1 receptor [gi:399890]
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9
[SID103195252]
Ki 0.056Binding affinity towards human M1 receptor. [AID141174, Type: Literature]
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10
[SID103195252]
Ki 0.058Binding affinity towards human alpha-1 adrenergic receptor [AID36113, Type: Literature]
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11
[SID103195252]
Ki 0.069Binding affinity towards human D2 dopamine receptor. [AID63070, Type: Literature]
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12
[SID103195252]
Ki 0.082Binding affinity for human 5-hydroxytryptamine 2A receptor [AID5199, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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13
[SID103195252]
IC50 0.0862DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168244]
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14
[SID103195252]
Ki 0.087Binding affinity towards human alpha-2 adrenergic receptor [AID36199, Type: Literature]
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15
[SID103195252]
IC50 0.0966DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168243]
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16
[SID103195252]
Ki 0.1Binding affinity to adrenergic alpha1A receptor (unknown origin) by PDSP assay [AID1119689, Type: confirmatory]Alpha-1A adrenergic receptor [gi:1168246]
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17
[SID103195252]
Ki 0.1Binding affinity to human cloned muscarinic M1 receptor [AID342774, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113118]
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18
[SID103195252]
Ki 0.1Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay [AID1119694, Type: confirmatory]Alpha-2C adrenergic receptor [gi:20141211]
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19
[SID103195252]
Ki 0.1Binding affinity to adrenergic alpha1B receptor (unknown origin) by PDSP assay [AID1119690, Type: confirmatory]Alpha-1B adrenergic receptor [gi:116241241]
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20
[SID103195252]
IC50 0.1003DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: confirmatory]Alpha-2B adrenergic receptor [gi:613504690]
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