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quetiapine (CID 5002) - Compound BioActivity Data
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BioActivity Outcomes:
Active(86)
 
 
Inactive(792)
 
 
Inconclusive(34)
 
 
Unspecified(309)
 
 
Top Targets:
7TM GPCR Srx(59)
 
 
 
 
7TM GPCR Srsx(42)
 
 
 
 
p450(13)
 
 
 
 
NR LBD ER(9)
 
 
 
PLDc mTdp1 2(8)
 
 
 
 
BioAssay Types:
Confirmatory(459)
 
 
 
 
 
Screening(376)
 
 
 
 
Literature(200)
 
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(322)
 
 
 
 
 
IC50(148)
 
 
 
 
Ki(40)
 
 
 
EC50(4)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1016    Data Row: 1221   Total Pages: 62   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103195252]
Ki 0.0045Binding affinity towards human alpha-1 adrenergic receptor [AID36116, Type: Literature]
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2
[SID103195252]
Ki 0.0087Binding affinity to human cloned histamine H1 receptor [AID342782, Type: Literature]Histamine H1 receptor [gi:547645]
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3
[SID103195252]
Ki 0.019Binding affinity towards human histamine H1 receptor [AID87242, Type: Literature]
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4
[SID103195252]
Ki 0.021Binding affinity towards human H1 receptor [AID87244, Type: Literature]
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5
[SID103195252]
IC50 0.0245DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: confirmatory]Alpha-1B adrenergic receptor [gi:543734]
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6
[SID103195252]
IC50 0.0396DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: confirmatory]Histamine H1 receptor [gi:547645]
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7
[SID103195252]
IC50 0.04Displacement of [3H]mepyramine from H1R in rat brain [AID330561, Type: Literature]Histamine H1 receptor [gi:399890]
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8
[SID103195252]
Ki 0.056Binding affinity towards human M1 receptor. [AID141174, Type: Literature]
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9
[SID103195252]
Ki 0.058Binding affinity towards human alpha-1 adrenergic receptor [AID36113, Type: Literature]
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10
[SID103195252]
Ki 0.069Binding affinity towards human D2 dopamine receptor. [AID63070, Type: Literature]
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11
[SID103195252]
Ki 0.082Binding affinity for human 5-hydroxytryptamine 2A receptor [AID5199, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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12
[SID103195252]
IC50 0.0862DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168244]
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13
[SID103195252]
Ki 0.087Binding affinity towards human alpha-2 adrenergic receptor [AID36199, Type: Literature]
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14
[SID103195252]
IC50 0.0966DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168243]
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15
[SID103195252]
Ki 0.1Binding affinity to human cloned muscarinic M1 receptor [AID342774, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113118]
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16
[SID103195252]
IC50 0.1003DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: confirmatory]Alpha-2B adrenergic receptor [gi:27151763]
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17
[SID103195252]
Ki 0.101Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in CHO cells after 60 mins by liquid scintillation counting [AID659850, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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18
[SID103195252]
IC50 0.1178DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: confirmatory]5-hydroxytryptamine receptor 2A [gi:543727]
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19
[SID103195252]
Ki 0.12Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptor [AID5197, Type: Literature]
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20
[SID103195252]
Ki 0.125Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting [AID659852, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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