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quetiapine (CID 5002) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(84)
 
 
Inactive(779)
 
 
Inconclusive(39)
 
 
Unspecified(174)
 
 
Top Targets:
7TM GPCR Srx(58)
 
 
 
 
7TM GPCR Srsx(42)
 
 
 
 
p450(13)
 
 
 
 
NR LBD ER(9)
 
 
 
NR LBD AR(8)
 
 
 
 
BioAssay Types:
Screening(375)
 
 
 
 
Confirmatory(342)
 
 
 
 
 
Literature(187)
 
 
 
 
 
Summary(24)
 
 
 
BioActivity Types:
Potency(321)
 
 
 
 
 
IC50(148)
 
 
 
 
Ki(40)
 
 
 
EC50(4)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 879    Data Row: 1076   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103195252]
Ki 0.0045Binding affinity towards human alpha-1 adrenergic receptor [AID36116, Type: Literature]
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2
[SID103195252]
Ki 0.0087Binding affinity to human cloned histamine H1 receptor [AID342782, Type: Literature]Histamine H1 receptor [gi:547645]
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3
[SID103195252]
Ki 0.019Binding affinity towards human histamine H1 receptor [AID87242, Type: Literature]
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4
[SID103195252]
Ki 0.021Binding affinity towards human H1 receptor [AID87244, Type: Literature]
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5
[SID103195252]
IC50 0.0245DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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6
[SID103195252]
IC50 0.0396DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
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7
[SID103195252]
IC50 0.04Displacement of [3H]mepyramine from H1R in rat brain [AID330561, Type: Literature]Histamine H1 receptor [gi:399890]
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8
[SID103195252]
Ki 0.056Binding affinity towards human M1 receptor. [AID141174, Type: Literature]
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9
[SID103195252]
Ki 0.058Binding affinity towards human alpha-1 adrenergic receptor [AID36113, Type: Literature]
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10
[SID103195252]
Ki 0.069Binding affinity towards human D2 dopamine receptor. [AID63070, Type: Literature]
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11
[SID103195252]
Ki 0.082Binding affinity for human 5-hydroxytryptamine 2A receptor [AID5199, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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12
[SID103195252]
IC50 0.0862DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
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13
[SID103195252]
Ki 0.087Binding affinity towards human alpha-2 adrenergic receptor [AID36199, Type: Literature]
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14
[SID103195252]
IC50 0.0966DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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15
[SID103195252]
Ki 0.1Binding affinity to human cloned muscarinic M1 receptor [AID342774, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113118]
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16
[SID103195252]
IC50 0.1003DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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17
[SID103195252]
Ki 0.101Displacement of [3H]ketanserin from human recombinant 5HT2A receptor expressed in CHO cells after 60 mins by liquid scintillation counting [AID659850, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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18
[SID103195252]
IC50 0.1178DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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19
[SID103195252]
Ki 0.12Binding affinity towards human serotonin 5-hydroxytryptamine 2A receptor [AID5197, Type: Literature]
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20
[SID103195252]
Ki 0.125Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting [AID659852, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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21
[SID103195252]
Ki 0.18Binding affinity to human cloned dopamine D2 receptor [AID342777, Type: Literature]D(2) dopamine receptor [gi:118206]
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22
[SID103195252]
Ki 0.18Displacement of [3H]spiperone from dopamine D2 receptor in rat straitum tissue after 20 mins by scintillation counting [AID620968, Type: Literature]D(2) dopamine receptor [gi:47117674]
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23
[SID103195252]
IC50 0.2135DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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24
[SID103195252]
Ki 0.22Binding affinity to human cloned 5HT2A receptor [AID342784, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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25
[SID103195252]
Ki 0.22In vitro binding affinity for 5-hydroxytryptamine 2 receptor [AID5124, Type: Literature]
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26
[SID103195252]
Ki 0.22Displacement of [3H]ketanserin from 5HT2A in rat brain cerebral cortex after 20 mins by scintillation counting [AID620967, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
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27
[SID103195252]
Ki 0.23Displacement of [3H]8OH-DPAT from 5HT1A in rat brain cerebral cortex after 15 mins by scintillation counting [AID620966, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
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28
[SID103195252]
Ki 0.23Binding affinity to human cloned 5HT1A receptor [AID342783, Type: Literature]5-hydroxytryptamine receptor 1A [gi:231454]
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29
[SID103195252]
Ki 0.31Binding affinity towards human Dopamine receptor D2 [AID63060, Type: Literature]
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30
[SID103195252]
Ki 0.32Binding affinity to human cloned dopamine D3 receptor [AID342778, Type: Literature]D(3) dopamine receptor [gi:1169206]
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31
[SID103195252]
IC50 0.33Inhibition of spiropiperidone binding at dopamine receptor D2 of rat. [AID64459, Type: Literature]
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32
[SID103195252]
Ki 0.34Binding affinity towards human dopamine receptor D3 [AID65121, Type: Literature]
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33
[SID103195252]
Ki 0.39Binding affinity against dopamine receptor D1 [AID63345, Type: Literature]
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34
[SID103195252]
IC50 0.4208DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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35
[SID103195252]
IC50 0.4293DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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36
[SID103195252]
Ki 0.65Binding affinity towards human Dopamine receptor D3 [AID65785, Type: Literature]
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37
[SID103195252]
Ki 0.68Binding affinity to rat NET [AID342786, Type: Literature]Norepinephrine transporter [gi:81890335]
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38
[SID103195252]
Ki 0.83Binding affinity towards human 5-hydroxytryptamine 1 receptor [AID3657, Type: Literature]
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39
[SID103195252]
Ki 1.02Binding affinity towards human muscarinic receptor [AID141100, Type: Literature]
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40
[SID103195252]
Ki 1.1Binding affinity towards human alpha-2 adrenergic receptor [AID36197, Type: Literature]
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41
[SID103195252]
IC50 1.1632DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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42
[SID103195252]
Ki 1.3Binding affinity to human cloned dopamine D1 receptor [AID342775, Type: Literature]D(1A) dopamine receptor [gi:118228]
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43
[SID103195252]
IC50 1.3299DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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44
[SID103195252]
Ki 1.4Binding affinity to human cloned 5HT6 receptor [AID342773, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1703010]
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45
[SID103195252]
Ki 1.4Binding affinity to human cloned 5HT2C receptor [AID342781, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112816]
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46
[SID103195252]
IC50 1.4264DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: other]
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47
[SID103195252]
Ki 1.5Binding affinity towards human 5-hydroxytryptamine 2C receptor [AID5616, Type: Literature]
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48
[SID103195252]
IC50 1.5211DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: other]
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49
[SID103195252]
IC50 1.5787DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M4 [gi:23503039]
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50
[SID103195252]
Ki 1.6Binding affinity towards human dopamine-4.2 receptor [AID61808, Type: Literature]
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