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ML239 (CID 49843203) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(2)
 
 
Active(8)
 
 
Inactive(23)
 
 
Inconclusive(2)
 
 
Top Targets:
NR DBD CAR(3)
 
 
FReD(2)
 
 
ZnMc TACE lik..(2)
 
 
AdoMet MTases(1)
 
 
PI-PLCc gamma(1)
 
 
BioAssay Types:
Screening(20)
 
 
Confirmatory(13)
 
 
 
 
Summary(2)
 
 
BioActivity Types:
AC50(12)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 33    Data Row: 35   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104170348]
Summary of Broad Institute MLPCN Breast Cancer Stem Cell Toxicity Project [AID2721, Type: summary]
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2
[SID114279607]
Summary of Broad Institute MLPCN Breast Cancer Stem Cell Toxicity Project [AID2721, Type: summary]
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3
[SID104170348]
AC50_uM 0.11Luminescence-based toxicity of HMLE_shTWIST Breast Cancer Stem Cell-like cells_2058-07_Inhibitor_Dose_DryPowder_Activity [AID588703, Type: confirmatory]
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4
[SID104170348]
AC50_uM 0.47Luminescence-based toxicity of HMLE_shECAD Breast Cancer Stem Cell-like cells_2058-06_Inhibitor_Dose_DryPowder_Activity [AID588704, Type: confirmatory]
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5
[SID104170348]
AC50_uM 1.164Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells Measured in Cell-Based System Using Plate Reader - 2058-01_Inhibitor_Dose_DryPowder_Activity_Set2 [AID493226, Type: confirmatory]
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6
[SID104170348]
AC50_uM 1.439Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells Measured in Cell-Based System Using Plate Reader - 2058-01_Inhibitor_Dose_DryPowder_Activity_Set5 [AID504535, Type: confirmatory]
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7
[SID104170348]
AC50_uM 1.509Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells Measured in Cell-Based System Using Plate Reader - 2058-01_Inhibitor_Dose_DryPowder_Activity_Set6 [AID504667, Type: confirmatory]
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8
[SID104170348]
AC50_uM 1.698Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells Measured in Cell-Based System Using Plate Reader - 2058-01_Inhibitor_Dose_DryPowder_Activity_Set7 [AID504788, Type: confirmatory]
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9
[SID104170348]
AC50_uM 2.81Luminescence-based toxicity of MDA231 Breast Cancer cells_2058-09_Inhibitor_Dose_DryPowder_Activity [AID588705, Type: confirmatory]
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10
[SID104170348]
AC50_uM 27.577HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP Measured in Cell-Based System Using Plate Reader - 2058-02_Inhibitor_Dose_DryPowder_Activity_Set2 [AID504325, Type: confirmatory]
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11
[SID104170348]
AC50_uM HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP Measured in Cell-Based System Using Plate Reader - 2058-02_Inhibitor_Dose_DryPowder_Activity_Set7 [AID504789, Type: confirmatory]
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12
[SID104170348]
AC50_uM Luminescence-based toxicity of Human Mammary Epithelial (HMLE) cells_2058-08_Inhibitor_Dose_DryPowder_Activity [AID588702, Type: confirmatory]
View
13
[SID104170348]
Orthogonal assay for the inhibition of tumorsphere formation Measured in Cell-Based System Using Imaging - 2058-03_Inhibitor_SinglePoint_DryPowder_Activity [AID504623, Type: confirmatory]
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14
[SID143472203]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. [AID720582, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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15
[SID143472203]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
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16
[SID143472203]
TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC) [AID720596, Type: screening]major prion protein preproprotein [Homo sapiens] [gi:4506113]
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17
[SID143472203]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
View
18
[SID143472203]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
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19
[SID143472203]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID686964, Type: screening]Methyl-CpG binding domain protein 2 [Homo sapiens] [gi:21595776]
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20
[SID143472203]
Epi Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID720702, Type: screening]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
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21
[SID143472203]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] [AID720508, Type: screening]Chain E, Fragment Double-D From Human Fibrin [gi:28373962]
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22
[SID143472203]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] [AID720509, Type: screening]Chain E, Fragment Double-D From Human Fibrin [gi:28373962]
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23
[SID143472203]
Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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24
[SID143472203]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12). [AID687014, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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25
[SID143472203]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12) [AID652067, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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26
[SID143472203]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite S. stercoralis (ssDAF-12) [AID652126, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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27
[SID143472203]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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28
[SID143472203]
Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID743445, Type: screening]histone-lysine N-methyltransferase NSD2 isoform 1 [Homo sapiens] [gi:109633019]
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29
[SID143472203]
Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of binding of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) to methylated oligonucleotide [AID687016, Type: screening]E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] [gi:115430235]
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30
[SID143472203]
QFRET-based biochemical high throughput primary assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) [AID743126, Type: screening]phospholipase A2, group III [Homo sapiens] [gi:119580345]
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31
[SID143472203]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-beta3). [AID720704, Type: screening]Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] [gi:148745659]
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32
[SID143472203]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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33
[SID143472203]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4). [AID720543, Type: screening]abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] [gi:326937491]
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34
[SID104170348]
AC50_uM HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP Measured in Cell-Based System Using Plate Reader - 2058-02_Inhibitor_Dose_DryPowder_Activity_Set6 [AID504666, Type: confirmatory]
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35
[SID104170348]
AC50_uM HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP Measured in Cell-Based System Using Plate Reader - 2058-02_Inhibitor_Dose_DryPowder_Activity_Set5 [AID504533, Type: confirmatory]
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