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CHEMBL3099773 (CID 49837912) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(2)
 
 
Active(8)
 
 
Inactive(6)
 
 
Unspecified(23)
 
 
Top Targets:
7tm 4(16)
 
 
 
 
 
SLC6sbd DAT1(1)
 
 
BioAssay Types:
Literature(27)
 
 
 
 
Confirmatory(9)
 
 
 
Summary(2)
 
 
BioActivity Types:
EC50(11)
 
 
 
 
Ki(2)
 
 
 
IC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 36    Data Row: 39   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID104164387]
Summary Assay for Selective Agonists of NTR1 [AID493055, Type: summary]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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2
[SID126723249]
Summary Assay for Selective Agonists of NTR1 [AID493055, Type: summary]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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3
[SID194180257]
EC50 0.298Agonist activity at NTR1 (unknown origin) expressed in CHO cells assessed as Ca2+ mobilization by Fluo-4 NW dye-based fluorescence assay [AID1061680, Type: Literature]Neurotensin receptor type 1 [gi:62297312]
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4
[SID104164387]
IC50_Mean 0.298SAR analysis of small molecule agonists of the NTR1 receptor in a dose response fluorescent-based calcium flux assay [AID602459, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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5
[SID194180257]
EC50 2Agonist activity at NTR1 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay [AID1061686, Type: Literature]Neurotensin receptor type 1 [gi:62297312]
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6
[SID104164387]
EC50_Mean 2.01SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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7
[SID126723249]
EC50_Mean 4.14SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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8
[SID104164387]
EC50_Mean 6.1SAR analysis of small molecule agonists of the NTR1 receptor via a luminescent beta-arrestin assay [AID602427, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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9
[SID194180257]
Ki 10Inhibition of NTS1 receptor (unknown origin) [AID1061672, Type: Literature]Neurotensin receptor type 1 [gi:62297312]
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10
[SID104164387]
SAR analysis of small molecule agonists of the NTR1 receptor in a single concentration fluorescent-based calcium flux assay [AID602466, Type: other]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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11
[SID194180257]
Ki 10Inhibition of DAT (unknown origin) [AID1061671, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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12
[SID194180257]
EC50 40Agonist activity at GPR35 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay [AID1061683, Type: Literature]G-protein coupled receptor 35 [gi:68068087]
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13
[SID194180257]
LC50 50Cytotoxicity in human Fa2N-4 cells after 24 hrs [AID1061661, Type: Literature]
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14
[SID194180257]
EC50 80Agonist activity at NTR2 in human U2OS cells after 1 hr by beta-arrestin GFP reporter gene assay [AID1061684, Type: Literature]Neurotensin receptor type 2 [gi:311033404]
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15
[SID194180257]
Metabolic stability in mouse liver microsomes assessed as compound remaining at 1hr [AID1061662, Type: Literature]
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16
[SID194180257]
Metabolic stability in human liver microsomes assessed as compound remaining at 1 hr [AID1061663, Type: Literature]
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17
[SID194180257]
Metabolic stability in human plasma assessed as compound remaining at 3 hrs [AID1061664, Type: Literature]
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18
[SID194180257]
Metabolic stability in mouse plasma assessed as compound remaining at 3 hrs [AID1061665, Type: Literature]
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19
[SID194180257]
Plasma protein binding in mouse at 10 uM [AID1061666, Type: Literature]
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20
[SID194180257]
Plasma protein binding in human at 10 uM [AID1061667, Type: Literature]
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