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MLS003659054 (CID 49830234) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(21)
 
 
Inconclusive(1)
 
 
Unspecified(2)
 
 
Top Targets:
NR DBD CAR(3)
 
 
FReD(2)
 
 
ZnMc TACE lik..(2)
 
 
AdoMet MTases(1)
 
 
Hydrolase 4(1)
 
 
BioAssay Types:
Screening(21)
 
 
Literature(4)
 
 
 
 
Confirmatory(4)
 
 
BioActivity Types:
IC50(2)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 28    Data Row: 29   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103904142]
IC50 16.22A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (5) [AID493088, Type: confirmatory]
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2
[SID103904142]
Average IC50 20.8A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (8) [AID504820, Type: confirmatory]
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3
[SID163317626]
EC50 21.2Antiviral activity against Respiratory syncytial virus Long infected in human Hep2 cells assessed as reduction in virus-induced cytopathogenicity by Cell Titer-Glo assay [AID701507, Type: Literature]
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4
[SID103904142]
Average CC50 50An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) using synethesized compounds (8) [AID504818, Type: confirmatory]
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5
[SID103904142]
CC50 142.45An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) using synethesized compounds (5) [AID493090, Type: confirmatory]
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6
[SID163317626]
CC50 50Cytotoxicity against human Hep2 cells by Cell Titer-Glo assay [AID701508, Type: Literature]
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7
[SID163317626]
Selectivity index, ratio of CC50 for human Hep2 cells to EC50 for Respiratory syncytial virus Long infected in human Hep2 cells [AID701509, Type: Literature]
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8
[SID143472253]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. [AID720582, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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9
[SID143472253]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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10
[SID143472253]
TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC) [AID720596, Type: screening]major prion protein preproprotein [Homo sapiens] [gi:4506113]
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11
[SID143472253]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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12
[SID143472253]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
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13
[SID143472253]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID686964, Type: screening]Methyl-CpG binding domain protein 2 [Homo sapiens] [gi:21595776]
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14
[SID143472253]
Epi Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID720702, Type: screening]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
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15
[SID143472253]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] [AID720508, Type: screening]Chain E, Fragment Double-D From Human Fibrin [gi:28373962]
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16
[SID143472253]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] [AID720509, Type: screening]Chain E, Fragment Double-D From Human Fibrin [gi:28373962]
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17
[SID143472253]
Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein, partial [Homo sapiens] [gi:32425330]
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18
[SID143472253]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of the DAF-12 from the parasite H. glycines (hgDAF-12). [AID687014, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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19
[SID143472253]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12) [AID652067, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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20
[SID143472253]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite S. stercoralis (ssDAF-12) [AID652126, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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