SureCN10622661 (CID 49800048) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(172)
 
 
Inactive(16)
 
 
Inconclusive(10)
 
 
Unspecified(311)
 
 
Top Targets:
NR LBD GR(74)
 
 
 
 
 
NR LBD PR(47)
 
 
 
 
NR LBD ER(24)
 
 
 
 
NR LBD AR(22)
 
 
 
 
NR LBD MR(17)
 
 
 
 
BioAssay Types:
Literature(362)
 
 
 
 
 
BioActivity Types:
IC50(233)
 
 
 
 
Ki(37)
 
 
 
EC50(10)
 
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 509    Data Row: 509   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103771008]
IC50 8e-06Inhibition of CHO-K1 cells expressing glucocorticoid receptor [AID241689, Type: Literature]
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2
[SID103771008]
IC50 2.1e-05Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition of progesterone-induced luciferase transactivation activity after 24 hrs [AID345895, Type: Literature]Progesterone receptor [gi:90110048]
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3
[SID103771008]
IC50 2.1e-05Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition of progesterone-induced luciferase transactivation activity after 24 hrs [AID345895, Type: Literature]Progesterone receptor [gi:90110048]
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4
[SID103771008]
IC50 2.5e-05In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-B progesterone receptor [AID147649, Type: Literature]Progesterone receptor [gi:90110048]
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5
[SID103771008]
IC50 2.5e-05In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-B progesterone receptor [AID147649, Type: Literature]Progesterone receptor [gi:90110048]
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6
[SID103771008]
IC50 2.8e-05In vitro antgonist potency in transactivation assay in neuroblastoma cells expressing human PR-A progesterone receptor [AID147646, Type: Literature]Progesterone receptor [gi:90110048]
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7
[SID103771008]
IC50 2.8e-05In vitro antgonist potency in transactivation assay in neuroblastoma cells expressing human PR-A progesterone receptor [AID147646, Type: Literature]Progesterone receptor [gi:90110048]
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8
[SID103771008]
IC50 4.5e-05Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 48 hrs [AID345893, Type: Literature]Progesterone receptor [gi:90110048]
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9
[SID103771008]
IC50 4.5e-05Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 48 hrs [AID345893, Type: Literature]Progesterone receptor [gi:90110048]
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10
[SID103771008]
IC50 5e-05Antiprogestagenic activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity [AID461850, Type: Literature]Progesterone receptor [gi:90110048]
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11
[SID103771008]
IC50 5e-05Antiprogestagenic activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity [AID461850, Type: Literature]Progesterone receptor [gi:90110048]
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12
[SID103771008]
IC50 5.4e-05Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activity [AID309724, Type: Literature]
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13
[SID103771008]
Ki 0.0001Inhibition of human glucocorticoid receptor [AID238476, Type: Literature]Glucocorticoid receptor [gi:121069]
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14
[SID103771008]
Ki 0.0001Inhibition of human glucocorticoid receptor [AID238476, Type: Literature]Glucocorticoid receptor [gi:121069]
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15
[SID103771008]
Ki 0.0001Inhibition of human glucocorticoid receptor [AID238476, Type: Literature]Glucocorticoid receptor [gi:121069]
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16
[SID103771008]
Ki 0.0001Inhibition of human glucocorticoid receptor [AID238476, Type: Literature]Glucocorticoid receptor [gi:121069]
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17
[SID103771008]
IC50 0.00013Antagonist activity against progesterone receptor (PR) in an alkaline phosphatase assay in the T47D human breast carcinoma cell line [AID226104, Type: Literature]
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18
[SID103771008]
IC50 0.00018Concentration required to give half-maximal inhibition against human Progesterone receptor B isoform in co-transfected CV-1 cell lines. [AID162600, Type: Literature]
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19
[SID103771008]
IC50 0.00018Antagonistic activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells. [AID162117, Type: Literature]
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20
[SID103771008]
IC50 0.0002Inhibitory concentration against progesterone stimulated alkaline phosphatase activity in T47D human breast carcinoma cell line [AID208687, Type: Literature]
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21
[SID103771008]
IC50 0.0002Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity [AID494980, Type: Literature]Progesterone receptor [gi:90110048]
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22
[SID103771008]
IC50 0.0002Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity [AID494980, Type: Literature]Progesterone receptor [gi:90110048]
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23
[SID103771008]
IC50 0.0002Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line [AID162131, Type: Literature]Progesterone receptor [gi:90110048]
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24
[SID103771008]
IC50 0.0002Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line [AID162131, Type: Literature]Progesterone receptor [gi:90110048]
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25
[SID103771008]
IC50 0.0002Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells [AID405937, Type: Literature]Progesterone receptor [gi:90110048]
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26
[SID103771008]
IC50 0.0002Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells [AID405937, Type: Literature]Progesterone receptor [gi:90110048]
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27
[SID103771008]
IC50 0.0002Antagonist activity at progesterone receptor assessed as progesterone-induced alkaline phosphatase activity in human T47D cells [AID387086, Type: Literature]Progesterone receptor [gi:90110048]
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28
[SID103771008]
IC50 0.0002Antagonist activity at progesterone receptor assessed as progesterone-induced alkaline phosphatase activity in human T47D cells [AID387086, Type: Literature]Progesterone receptor [gi:90110048]
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29
[SID103771008]
IC50 0.0002Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase [AID326396, Type: Literature]Progesterone receptor [gi:90110048]
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30
[SID103771008]
IC50 0.0002Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase [AID326396, Type: Literature]Progesterone receptor [gi:90110048]
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31
[SID103771008]
Ki 0.00024Displacement of 10 nM [3H]dexamethasone from human Glucocorticoid receptor [AID74223, Type: Literature]Glucocorticoid receptor [gi:121069]
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32
[SID103771008]
Ki 0.00024Displacement of 10 nM [3H]dexamethasone from human Glucocorticoid receptor [AID74223, Type: Literature]Glucocorticoid receptor [gi:121069]
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33
[SID103771008]
Ki 0.00024Displacement of 10 nM [3H]dexamethasone from human Glucocorticoid receptor [AID74223, Type: Literature]Glucocorticoid receptor [gi:121069]
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34
[SID103771008]
Ki 0.00024Displacement of 10 nM [3H]dexamethasone from human Glucocorticoid receptor [AID74223, Type: Literature]Glucocorticoid receptor [gi:121069]
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35
[SID103771008]
Ki 0.00024Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature]Glucocorticoid receptor [gi:121069]
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36
[SID103771008]
Ki 0.00024Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature]Glucocorticoid receptor [gi:121069]
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37
[SID103771008]
Ki 0.00024Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature]Glucocorticoid receptor [gi:121069]
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38
[SID103771008]
Ki 0.00024Displacement of [3H]DEX from human glucocorticoid receptor [AID473409, Type: Literature]Glucocorticoid receptor [gi:121069]
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39
[SID103771008]
IC50 0.0003Inhibitory concentration for antagonistic activity towards human progesterone receptor (hPR) using the cotransfection assay in CV-1 cells [AID162124, Type: Literature]
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40
[SID103771008]
IC50 0.0003Antagonist activity against the Progesterone Receptor (PR) [AID162436, Type: Literature]
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41
[SID103771008]
IC50 0.0003Antagonist activity against progesterone receptor (PR) using PRE-luciferase plasmid co-transfected CV-1 cells [AID226106, Type: Literature]
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42
[SID103771008]
IC50 0.0003Inhibitory concentration against progesterone induced PRE-luciferase activity in CV-cells [AID47382, Type: Literature]
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43
[SID103771008]
EC50 0.0003Antagonistic activity at human progesterone receptor in CV-1 cells. [AID161798, Type: Literature]
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44
[SID103771008]
IC50 0.0003In vitro antagonist activity against human progesterone receptor isoform B(hPR-B) in mammalian(CV-1) cells [AID162121, Type: Literature]Progesterone receptor [gi:90110048]
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45
[SID103771008]
IC50 0.0003In vitro antagonist activity against human progesterone receptor isoform B(hPR-B) in mammalian(CV-1) cells [AID162121, Type: Literature]Progesterone receptor [gi:90110048]
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46
[SID103771008]
IC50 0.00035Antagonistic potency to the human progesterone receptor measured in the T-47D alkaline phosphatase assay [AID32841, Type: Literature]
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47
[SID103771008]
Ki 0.0004Displacement of [3H]dexamethasone from human recombinant GR [AID318132, Type: Literature]Glucocorticoid receptor [gi:121069]
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48
[SID103771008]
Ki 0.0004Displacement of [3H]dexamethasone from human recombinant GR [AID318132, Type: Literature]Glucocorticoid receptor [gi:121069]
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49
[SID103771008]
Ki 0.0004Displacement of [3H]dexamethasone from human recombinant GR [AID318132, Type: Literature]Glucocorticoid receptor [gi:121069]
View
50
[SID103771008]
Ki 0.0004Displacement of [3H]dexamethasone from human recombinant GR [AID318132, Type: Literature]Glucocorticoid receptor [gi:121069]
View