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MLS003123867 (CID 49795407) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(186)
 
 
Inconclusive(9)
 
 
Top Targets:
7TM GPCR Srsx(12)
 
 
 
7TM GPCR Srx(11)
 
 
RasGEF(4)
 
 
Toxin trans(3)
 
 
NR DBD CAR(3)
 
 
BioAssay Types:
Screening(154)
 
 
 
 
Confirmatory(38)
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(34)
 
 
 
 
EC50(3)
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 188    Data Row: 204   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103162983]
Potency 14.581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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2
[SID103162983]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID103162983]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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4
[SID103162983]
Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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5
[SID103162983]
Luminescence-based cell-based high throughput confirmation assay for biased ligands (agonists) of the melanocortin 4 receptor (MC4R) [AID602192, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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6
[SID103162983]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of sialic acid acetylesterase (SIAE) [AID1053197, Type: screening]Sialate O-acetylesterase [gi:74734243]
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7
[SID103162983]
Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of sialic acid acetylesterase (SIAE) [AID1117263, Type: screening]Sialate O-acetylesterase [gi:74734243]
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8
[SID103162983]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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9
[SID103162983]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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10
[SID103162983]
Potency 5.0119qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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11
[SID103162983]
Potency 35.4813qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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12
[SID103162983]
Potency 44.6684qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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13
[SID103162983]
EC50 64.587Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID602264, Type: confirmatory]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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14
[SID103162983]
EC50 64.587Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID602264, Type: confirmatory]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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15
[SID103162983]
Potency 89.1251qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720707, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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16
[SID103162983]
EC50 89.206Luminescence-based cell-based high throughput dose response assay for biased ligands (agonists) of the melanocortin 4 receptor (MC4R) [AID602263, Type: confirmatory]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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17
[SID103162983]
TRFRET-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): antagonists of MC4R [AID540295, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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18
[SID103162983]
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID602194, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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19
[SID103162983]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of alpha/beta hydrolase domain containing 4 (ABHD4). [AID720543, Type: screening]abhydrolase domain-containing protein 4 isoform 1 [Mus musculus] [gi:326937491]
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20
[SID103162983]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1) [AID1117264, Type: screening]RNA-editing ligase 1, mitochondrial [gi:342179211]
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