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BioActivity Data for Compound MLS003120076 (CID 49790199)

BioActivity Outcomes:
Active(11)
 
 
Inactive(191)
 
 
Inconclusive(6)
 
 
Top Targets:
7tm 4(17)
 
 
 
ZnMc TACE lik..(6)
 
 
 
RasGEF(4)
 
 
MetRS core(3)
 
 
NR DBD CAR(3)
 
 
BioAssay Types:
Screening(157)
 
 
 
Confirmatory(39)
 
 
 
 
Literature(9)
 
 
BioAssay Categories:
Organism-base..(5)
 
 
Biochemical(54)
 
 
 
Toxicity(2)
 
 
Cell-based(56)
 
 
 
BioActivity Types:
Potency(39)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 194    Data Row: 208   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103075025]
Potency 4.983qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen [AID651815, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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2
[SID103075025]
Potency 12.5168qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen [AID651813, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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3
[SID103075025]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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4
[SID103075025]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID103075025]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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6
[SID103075025]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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7
[SID103075025]
Counterscreen for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS): Luminescence-based cell-based high throughput assay to identify compounds that are cytotoxic to Jurkat human T lymphocyte cells [AID624413, Type: screening]
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8
[SID103075025]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624268, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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9
[SID103075025]
Luminescence-based biochemical high throughput confirmation assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624412, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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10
[SID103075025]
Fluorescent Polarization-based biochemical high throughput orthogonal assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID651607, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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11
[SID103075025]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. [AID720582, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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12
[SID103075025]
Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput screening assay to identify inhibitors of ADAM10 [AID743256, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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13
[SID103075025]
QFRET-based biochemical high throughput confirmation assay to identify exosite inhibitors of ADAM10. [AID743208, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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14
[SID103075025]
Turbidometric Biochemical Primary HTS to identify inhibitors of ERp5 Measured in Biochemical System Using Plate Reader - 7002-01_Inhibitor_SinglePoint_HTS_Activity [AID651711, Type: screening]Protein disulfide-isomerase A6 [gi:2501205]
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15
[SID103075025]
Potency qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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16
[SID103075025]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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17
[SID103075025]
Potency A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression [AID624263, Type: confirmatory]Parkin [Homo sapiens] [gi:3063388]
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18
[SID103075025]
Potency qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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19
[SID103075025]
uHTS identification of inhibitors of cullin neddylation in a TR-FRET assay [AID651699, Type: screening]NEDD8-activating enzyme E1 regulatory subunit isoform a [Homo sapiens] [gi:4502169]
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20
[SID103075025]
uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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