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AGN-PC-087ZYX (CID 49789494) - Compound BioActivity Data
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BioActivity Outcomes:
Active(16)
 
 
Inactive(182)
 
 
Inconclusive(10)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
7TM GPCR Srx(7)
 
 
RasGEF(4)
 
 
Toxin trans(3)
 
 
NR DBD CAR(3)
 
 
BioAssay Types:
Screening(153)
 
 
 
Confirmatory(37)
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(33)
 
 
 
 
AC50(2)
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 194    Data Row: 208   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103073973]
Potency 4.1095qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID103073973]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID103073973]
Potency 11.2202qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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4
[SID103073973]
Potency 19.9526qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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5
[SID103073973]
HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Inhibitor_SinglePoint_CherryPick_Activity [AID743190, Type: other]
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6
[SID103073973]
uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]G-protein coupled receptor 183 [Homo sapiens] [gi:4826706]
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7
[SID103073973]
AbsAC40_uM Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_Dose_CherryPick_Activity [AID651717, Type: confirmatory]
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8
[SID103073973]
Confirm compound inhibition to esBAF complex through de-repress target gene Ring1 in qPCR assay Measured in Cell-Based System Using RT-PCR - 2141-04_Inhibitor_SinglePoint_CherryPick_Activity [AID743176, Type: other]
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9
[SID103073973]
Confirm compound inhibition to esBAF complex through repress target gene Fgf4 in qPCR assay Measured in Cell-Based System Using RT-PCR - 2141-03_Inhibitor_SinglePoint_CherryPick_Activity [AID743177, Type: other]
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10
[SID103073973]
Confirm compound inhibition to esBAF complex through de-repress target gene Bmi1 in qPCR assay Measured in Cell-Based System Using RT-PCR - 2141-02_Inhibitor_SinglePoint_CherryPick_Activity [AID743180, Type: other]
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11
[SID103073973]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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12
[SID103073973]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651608, Type: screening]ADP-ribosylation factor GTPase-activating protein 1 [Rattus norvegicus] [gi:21489979]
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13
[SID103073973]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651572, Type: screening]ADP-ribosylation factor GTPase-activating protein 1 [Rattus norvegicus] [gi:21489979]
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14
[SID103073973]
FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651710, Type: screening]DNA repair protein RAD52 homolog isoform a [Homo sapiens] [gi:109637798]
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15
[SID103073973]
Fluorescence polarization-based biochemical high throughput primary assay to identify inhibitors of sialic acid acetylesterase (SIAE) [AID1053197, Type: screening]Sialate O-acetylesterase [gi:74734243]
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16
[SID103073973]
Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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17
[SID103073973]
IC50 164.757Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651763, Type: confirmatory]ADP-ribosylation factor GTPase-activating protein 1 [Rattus norvegicus] [gi:21489979]
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18
[SID103073973]
Potency qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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19
[SID103073973]
Potency qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720709, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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20
[SID103073973]
Potency qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720707, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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