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MLS003120467 (CID 49789464) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(193)
 
 
Inconclusive(4)
 
 
Unspecified(6)
 
 
Top Targets:
7tm 4(17)
 
 
HIF-1a CTAD(13)
 
 
 
 
RasGEF(4)
 
 
Anthrax-tox M(3)
 
 
SRC-1(3)
 
 
 
BioAssay Types:
Screening(154)
 
 
 
 
Confirmatory(44)
 
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(34)
 
 
 
IC50(10)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 187    Data Row: 210   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103073926]
IC50_HIF-2a_PANC_Mean 1.85Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_7, Type: confirmatory]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
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2
[SID103073926]
IC50_HIF-1a_Mean 51.45Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_1, Type: confirmatory]hypoxia-inducible factor 1-alpha isoform 1 [Homo sapiens] [gi:4504385]
View
3
[SID103073926]
IC50_1_HIF-1a Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_4, Type: confirmatory]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
4
[SID103073926]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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5
[SID103073926]
uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID624352, Type: screening]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
6
[SID103073926]
Single concentration confirmation of uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID651580, Type: screening]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
7
[SID103073926]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID651957, Type: screening]nuclear receptor coactivator 2 [Homo sapiens] [gi:5729858]
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8
[SID103073926]
IC50_2_HIF-2a 0.777Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_6, Type: confirmatory]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
9
[SID103073926]
IC50_1_HIF-2a 0.938Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_5, Type: confirmatory]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
10
[SID103073926]
IC50_2_HIF-2a_PANC 1.673Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_9, Type: confirmatory]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
11
[SID103073926]
IC50_1_HIF-2a_PANC 2.03Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_8, Type: confirmatory]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
12
[SID103073926]
IC50_1_HIF-1a 3.893Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_2, Type: confirmatory]hypoxia-inducible factor 1-alpha isoform 1 [Homo sapiens] [gi:4504385]
View
13
[SID103073926]
IC50_2_HIF-1a 99Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581_3, Type: confirmatory]hypoxia-inducible factor 1-alpha isoform 1 [Homo sapiens] [gi:4504385]
View
14
[SID103073926]
IC50_1_HIF-1a 3.893Dose response confirmation of uHTS identification of HIF-2a Inhibitors in screening - selectivity counterscreen assays [AID651581, Type: confirmatory]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
15
[SID103073926]
VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
View
16
[SID103073926]
Single concentration confirmation of HIF-2a Inhibitors in a HIF-1a counterscreen in human MiAPaCa-2 Cells luciferase reporter assay [AID651589, Type: screening]hypoxia-inducible factor 1-alpha isoform 1 [Homo sapiens] [gi:4504385]
View
17
[SID103073926]
TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC) [AID720596, Type: screening]major prion protein preproprotein [Homo sapiens] [gi:4506113]
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18
[SID103073926]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]receptor-interacting serine/threonine-protein kinase 2 [Homo sapiens] [gi:4506537]
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19
[SID103073926]
uHTS identification of inhibitors of cullin neddylation in a TR-FRET assay [AID651699, Type: screening]NEDD8-conjugating enzyme Ubc12 [Homo sapiens] [gi:4507791]
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20
[SID103073926]
uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]G-protein coupled receptor 183 [Homo sapiens] [gi:4826706]
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