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BioActivity Data for Compound MLS003123272 (CID 49786470)

BioActivity Outcomes:
Active(11)
 
 
Inactive(188)
 
 
Inconclusive(10)
 
 
Top Targets:
7tm 4(17)
 
 
RasGEF(4)
 
 
 
Toxin trans(3)
 
 
NR DBD CAR(3)
 
 
ArfGap(3)
 
 
 
BioAssay Types:
Screening(158)
 
 
 
 
Confirmatory(39)
 
 
 
 
Literature(9)
 
 
BioAssay Categories:
Organism-base..(5)
 
 
Biochemical(52)
 
 
 
Toxicity(2)
 
 
Cell-based(54)
 
 
BioActivity Types:
Potency(35)
 
 
 
 
AC50(2)
 
 
 
EC50(1)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 195    Data Row: 209   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103060224]
AC50_uM 5.06FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog isoform a [Homo sapiens] [gi:109637798]
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2
[SID103060224]
Potency 11.2202qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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3
[SID103060224]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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4
[SID103060224]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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5
[SID103060224]
Inhibition of Exocytosis of Lytic Granulocytes as measured by LAMP-1 externalization with compounds from CherryPick01 [AID720663, Type: screening]
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6
[SID103060224]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651572, Type: screening]ADP-ribosylation factor GTPase-activating protein 1 [Rattus norvegicus] [gi:21489979]
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7
[SID103060224]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651608, Type: screening]ADP-ribosylation factor GTPase-activating protein 1 [Rattus norvegicus] [gi:21489979]
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8
[SID103060224]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with compounds from Cherry Pick01 [AID651954, Type: screening]
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9
[SID103060224]
FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651710, Type: screening]DNA repair protein RAD52 homolog isoform a [Homo sapiens] [gi:109637798]
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10
[SID103060224]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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11
[SID103060224]
Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]protein AF-9 isoform a [Homo sapiens] [gi:156104889]
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12
[SID103060224]
Potency 12.5893qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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13
[SID103060224]
IC50 18.306Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651763, Type: confirmatory]ADP-ribosylation factor GTPase-activating protein 1 [Rattus norvegicus] [gi:21489979]
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14
[SID103060224]
Inhibition of Protein Kinase C activation by compounds from CherryPick01 [AID720666, Type: screening]
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15
[SID103060224]
Inhibition of MAPKK activation by compounds from CherryPick01 [AID720667, Type: screening]
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16
[SID103060224]
Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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17
[SID103060224]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID686964, Type: screening]Methyl-CpG binding domain protein 2 [Homo sapiens] [gi:21595776]
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18
[SID103060224]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) [AID588354, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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19
[SID103060224]
Potency qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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20
[SID103060224]
Epi Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID720702, Type: screening]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
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