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Propranolol (CID 4946) - Compound BioActivity Data
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BioActivity Outcomes:
Active(108)
 
 
Inactive(123)
 
 
Inconclusive(29)
 
 
Unspecified(643)
 
 
Top Targets:
7TM GPCR Srsx(52)
 
 
 
 
7TM GPCR Srx(39)
 
 
 
 
 
p450(15)
 
 
 
ABC MTABC3 MD..(10)
 
 
GT1 Gtf like(7)
 
 
BioAssay Types:
Literature(640)
 
 
 
 
 
Confirmatory(99)
 
 
 
 
Screening(11)
 
 
BioActivity Types:
IC50(150)
 
 
 
 
 
Potency(94)
 
 
 
 
Kd(60)
 
 
 
Ki(15)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 882    Data Row: 903   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164951]
Kd 0.00024Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis [AID620391, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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2
[SID103164951]
Kd 0.000603Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cells [AID620387, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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3
[SID103164951]
Kd 0.00079Binding affinity to human adrenergic beta2 receptor [AID426242, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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4
[SID103164951]
Kd 0.000977In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha contracted guinea pig trachea [AID40870, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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5
[SID103164951]
IC50 0.00112DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: other]Beta-2 adrenergic receptor [gi:296439450]
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6
[SID103164951]
Kd 0.00126Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation [AID40877, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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7
[SID103164951]
Kd 0.00126In vitro blocking of beta adrenergic receptor in guinea pig trachea [AID41156, Type: Literature]
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8
[SID103164951]
Kd 0.00126Inhibition of isoproterenol-induced responses in guinea pig trachea. [AID80626, Type: Literature]
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9
[SID103164951]
Kd 0.00155Evaluated for Adrenoreceptor from guinea pig left atrium by using isoproterenol as agonist. [AID63493, Type: Literature]
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10
[SID103164951]
Kd 0.00174In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea pig atrial preparations [AID42218, Type: Literature]
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11
[SID103164951]
Kd 0.00174In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated guinea pig atria [AID39943, Type: Literature]
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12
[SID103164951]
Kd 0.00178Compound was evaluated for competitive antagonism of beta-2 adrenergic receptor in rat uterus measured as pA2 (-log KB) [AID41482, Type: Literature]
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13
[SID103164951]
Kd 0.00182Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis [AID620389, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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14
[SID103164951]
Kd 0.002Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation [AID39950, Type: Literature]
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15
[SID103164951]
Kd 0.002In Vitro inhibition of the beta adrenergic receptor in guinea pig atria [AID41154, Type: Literature]
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16
[SID103164951]
Kd 0.002Negative log concentration effecting 50% blockade of isoproterenol-induced rate responses in vitro in guinea pig right atria. [AID79515, Type: Literature]
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17
[SID103164951]
Ki 0.0023Inhibition of [3H]dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes. [AID218718, Type: Literature]
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18
[SID103164951]
Kd 0.0024Beta adrenergic receptor blocking activity measured by the inotropic effect was determined 1 hr after pretreament of the right atria in guinea pig [AID41306, Type: Literature]
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19
[SID103164951]
Kd 0.0024Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig [AID79325, Type: Literature]
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20
[SID103164951]
Kd 0.0024Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer) [AID40395, Type: Literature]
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21
[SID103164951]
Ki 0.0024Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenolol [AID41754, Type: Literature]
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22
[SID103164951]
Kd 0.0024In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atria [AID42020, Type: Literature]
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23
[SID103164951]
Kd 0.0024Beta-1 adrenergic receptor blocking activity in atria of guinea pig. [AID42209, Type: Literature]
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24
[SID103164951]
Kd 0.00251Beta-1 adrenergic receptor activitation measured by isoprenaline-induced positive inotropic effect in guinea pig left atrium [AID42208, Type: Literature]
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25
[SID103164951]
IC50 0.00254DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) [AID625204, Type: other]Beta-1 adrenergic receptor [gi:48429211]
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26
[SID103164951]
IC50 0.003The compound was tested for the concentration to inhibit 50% of Beta adrenergic receptor isolated from rat ventricle homogenates [AID41610, Type: Literature]
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27
[SID103164951]
Kd 0.00302In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tracheal chains contracted with PGF2-alpha [AID40869, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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28
[SID103164951]
Kd 0.00309Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB) [AID42211, Type: Literature]
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29
[SID103164951]
Kd 0.00339Beta-2 adrenergic receptor blocking activity in trachea of guinea pig. [AID40867, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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30
[SID103164951]
Kd 0.00339The apparent pA2 value was measured for beta-2 adrenergic blocking activity on the trachea of guinea pig [AID79647, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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31
[SID103164951]
Kd 0.00339Antagonism of isoprenaline-induced relaxation of guinea pig tracheal chains, contracted with carbachol [AID79324, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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32
[SID103164951]
Kd 0.00339In vitro inhibitory activity against beta-2 adrenergic receptor determined as pA2 in guinea pig trachea [AID40873, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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33
[SID103164951]
Kd 0.00363Beta adrenergic receptor blocking activity measured by the chronotropic effect was determined 1 hr after pretreatment of the right atria in guinea pig [AID41305, Type: Literature]
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34
[SID103164951]
Kd 0.0038Positive inotropic effect was evaluated on atrial muscles of the guinea pig [AID79519, Type: Literature]
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35
[SID103164951]
IC50 0.004Concentration effective against displacing [3H]dihydroalprenolol from beta adrenergic receptor from canine ventricular tissue [AID41152, Type: Literature]
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36
[SID103164951]
Kd 0.00437Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria [AID40420, Type: Literature]
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37
[SID103164951]
Kd 0.00437Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria [AID40527, Type: Literature]
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38
[SID103164951]
Kd 0.00468Evaluated for Adrenoreceptor from guinea pig trachea by using isoproterenol as agonist. [AID63494, Type: Literature]
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39
[SID103164951]
Kd 0.00501Chronotropic effect studied in right atria isolated from guinea pig and is expressed in pA2. [AID80447, Type: Literature]
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40
[SID103164951]
Kd 0.00603Displacement of [3H]-CGP 12177 from human beta-1 adrenergic receptor expressed in CHOK1 cells [AID620386, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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41
[SID103164951]
Ki 0.0065Evaluated for beta-receptor affinity determined in rat brain membrane fraction with [3H]- dihydroalprenolol [AID218704, Type: Literature]
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42
[SID103164951]
Kd 0.00759Positive chronotropic effect was evaluated on atrial muscles of the guinea pig [AID79518, Type: Literature]
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43
[SID103164951]
Kd 0.00794Ionotropic effect in electrically driven left atrial preparation (Atria isolated from guinea pig) and is expressed in pA2. [AID79687, Type: Literature]
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44
[SID103164951]
Kd 0.00871Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria [AID42040, Type: Literature]
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45
[SID103164951]
ED50 0.0101In vitro evaluation on guinea pig trachea. EC50 which is the molar concentration required to give 50% inhibition of the isoproterenol response (1x10E-6M) was determined. [AID77095, Type: Literature]
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46
[SID103164951]
Kd 0.01122Compound was tested for its ability to block isoproterenol-induced vasodilation in anesthetized dogs. [AID61089, Type: Literature]
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47
[SID103164951]
IC50 0.012Tested for Beta Adrenergic receptor binding inhibition from canine ventricular tissue, using [3H]dihydroalprenolol as the radioligand in anesthetized dogs [AID41136, Type: Literature]
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48
[SID103164951]
Kd 0.01259Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea [AID42210, Type: Literature]
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49
[SID103164951]
IC50 0.017Tested for Beta-2 adrenergic receptor selectivity in canine lung tissue in anesthetized dogs [AID40703, Type: Literature]Beta-2 adrenergic receptor [gi:1703760]
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50
[SID103164951]
IC50 0.018Tested for Beta-1 adrenergic receptor selectivity in canine cardiac tissue in anesthetized dogs [AID42031, Type: Literature]
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