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Propranolol (CID 4946) - Compound BioActivity Data
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BioActivity Outcomes:
Active(112)
 
 
Inactive(123)
 
 
Inconclusive(32)
 
 
Unspecified(1866)
 
 
Top Targets:
7tm 4(99)
 
 
 
 
 
p450(15)
 
 
 
ABC MTABC3 MD..(10)
 
 
GT1 Gtf like(7)
 
 
ALBUMIN(6)
 
 
BioAssay Types:
Literature(714)
 
 
 
 
 
Confirmatory(219)
 
 
 
 
 
Screening(11)
 
 
BioActivity Types:
IC50(151)
 
 
 
 
 
Potency(95)
 
 
 
 
Kd(60)
 
 
 
Ki(21)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2112    Data Row: 2133   Total Pages: 107   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164951]
Kd 0.00024Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis [AID620391, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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2
[SID103164951]
Ki 0.00046Displacement of [3H]-CGP-12177 from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis [AID1061256, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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3
[SID103164951]
Kd 0.000603Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cells [AID620387, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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4
[SID103164951]
Kd 0.00079Binding affinity to human adrenergic beta2 receptor [AID426242, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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5
[SID103164951]
Kd 0.000977In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha contracted guinea pig trachea [AID40870, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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6
[SID103164951]
IC50 0.00112DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: confirmatory]Beta-2 adrenergic receptor [gi:296439450]
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7
[SID103164951]
Kd 0.00126Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation [AID40877, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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8
[SID103164951]
Kd 0.00126In vitro blocking of beta adrenergic receptor in guinea pig trachea [AID41156, Type: Literature]
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9
[SID103164951]
Kd 0.00126Inhibition of isoproterenol-induced responses in guinea pig trachea. [AID80626, Type: Literature]
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10
[SID103164951]
Kd 0.00155Evaluated for Adrenoceptor from guinea pig left atrium by using isoproterenol as agonist. [AID63493, Type: Literature]
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11
[SID103164951]
Kd 0.00174In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea pig atrial preparations [AID42218, Type: Literature]
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12
[SID103164951]
Kd 0.00174In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated guinea pig atria [AID39943, Type: Literature]
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13
[SID103164951]
Kd 0.00178Compound was evaluated for competitive antagonism of beta-2 adrenergic receptor in rat uterus measured as pA2 (-log KB) [AID41482, Type: Literature]
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14
[SID103164951]
Kd 0.00182Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis [AID620389, Type: Literature]Beta-1 adrenergic receptor [gi:48429211]
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15
[SID103164951]
Kd 0.002In Vitro inhibition of the beta adrenergic receptor in guinea pig atria [AID41154, Type: Literature]
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16
[SID103164951]
Kd 0.002Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation [AID39950, Type: Literature]
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17
[SID103164951]
Kd 0.002Negative log concentration effecting 50% blockade of isoproterenol-induced rate responses in vitro in guinea pig right atria. [AID79515, Type: Literature]
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18
[SID103164951]
Ki 0.0023Inhibition of [3H]dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes. [AID218718, Type: Literature]
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19
[SID103164951]
Kd 0.0024Beta-1 adrenergic receptor blocking activity in atria of guinea pig. [AID42209, Type: Literature]
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20
[SID103164951]
Kd 0.0024Beta adrenergic receptor blocking activity measured by the inotropic effect was determined 1 hr after pretreament of the right atria in guinea pig [AID41306, Type: Literature]
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