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Propofol (CID 4943) - Compound BioActivity Data
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BioActivity Outcomes:
Active(77)
 
 
Inactive(1336)
 
 
Inconclusive(92)
 
 
Unspecified(252)
 
 
Top Targets:
7TM GPCR Srx(38)
 
 
 
 
 
7TM GPCR Srsx(29)
 
 
 
 
NR LBD PPAR(29)
 
 
 
Neur chan LBD(29)
 
 
 
p450(29)
 
 
 
 
 
BioAssay Types:
Confirmatory(860)
 
 
 
 
 
Screening(375)
 
 
 
Literature(241)
 
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(801)
 
 
 
 
 
IC50(140)
 
 
 
 
EC50(22)
 
 
 
 
Kd(2)
 
 
Ki(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1130    Data Row: 1757   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174641]
Kd 0.23Agonist activity at GABAA assessed as enhancement of channel current [AID447577, Type: Literature]
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2
[SID103174641]
EC50 1.1Anesthetic effect on Xenopus laevis tadpole assessed as loss of spontaneous motion measured for 30 seconds after 30 mins [AID496984, Type: Literature]
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3
[SID103174641]
EC50 1.9Effective concentration required for reversible loss of righting reflex in Xenopus laevis tadpoles [AID246227, Type: Literature]
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4
[SID103174641]
EC50 1.99526Binding affinity to apoferritin by isothermal titration calorimetry [AID447576, Type: Literature]
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5
[SID103174641]
EC50 1.99526Loss of righting reflex (LORR) in tadpoles was determined for anesthetic activity [AID219761, Type: Literature]
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6
[SID103174641]
EC50 1.99526Potentiation of GABA responses at human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 [AID72642, Type: Literature]
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7
[SID103174641]
EC50 2.2Anesthetic activity in Xenopus laevis tadpoles assessed as loss of righting reflexes [AID697075, Type: Literature]
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8
[SID103174641]
EC50 2.8Anesthetic effect on Xenopus laevis tadpole assessed as loss of startle reflex after 30 mins [AID496985, Type: Literature]
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9
[SID103174641]
IC50 3.832DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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10
[SID103174641]
IC50 3.95Inhibition of [35S]TBPS binding to GABA-A receptor in rat cerebral cortex. [AID71848, Type: Literature]
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11
[SID103174641]
EC50 4.1GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=100 micro71547, Type: Literature]
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12
[SID90341256]
Potency 4.4668qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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13
[SID103174641]
EC50 5.2Agonist activity at human alpha1beta2gamma2L GABAA receptor expressed in Xenopus oocytes assessed as potentiation of GABA-induced current response by two-electrode voltage clamp electrophysiology assay [AID697074, Type: Literature]
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14
[SID103174641]
IC50 5.499DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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15
[SID103174641]
IC50 7.3Antagonist activity at Torpedo californica nACh receptor expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current response [AID696815, Type: Literature]
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16
[SID103174641]
IC50 7.596DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: other]Arachidonate 15-lipoxygenase [gi:126397]
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17
[SID103174641]
EC50 8Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunits [AID219778, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-1 [gi:23831128]
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18
[SID103174641]
EC50 8Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunits [AID219778, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:27808653]
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19
[SID103174641]
EC50 8Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunits [AID219778, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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20
[SID103174641]
IC50 8.1Inhibition of [35S]TBPS binding to GABA-A receptor rat whole brain membranes [AID71838, Type: Literature]
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21
[SID103174641]
IC50 8.3The concentration required to inhibit 50% of binding of [35S]TBPS to Gamma-aminobutyric acid A receptor to rat whole brain membranes. [AID71999, Type: Literature]
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22
[SID103174641]
IC50 9.393DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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23
[SID103174641]
Kd 10Binding affinity to horse spleen apoferritin using 1-AMA by photo-occlusion method [AID496990, Type: Literature]
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24
[SID103174641]
EC50 10Direct activation of human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 [AID72641, Type: Literature]
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25
[SID103174641]
EC50 11.2Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expressed in Xenopus oocytes [AID240319, Type: Literature]
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26
[SID103174641]
IC50 11.553DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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27
[SID103174641]
Km 12.3Kinetic parameter, Km on human hepatic microsomes. [AID222289, Type: Literature]
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28
[SID103174641]
IC50 14Inhibition of rat FAAH [AID346665, Type: Literature]Fatty-acid amide hydrolase 1 [gi:6225312]
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29
[SID103174641]
IC50 18In vitro inhibition of [35S]-TBPS binding to GABA-A receptor in rat whole brain membranes [AID72455, Type: Literature]
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30
[SID103174641]
IC50 18Inhibition of [35S]TBPS binding to Gamma-aminobutyric acid A receptor of rat brain membranes [AID71987, Type: Literature]
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31
[SID103174641]
Ki 19.5Inhibition of human erythrocyte CA2 esterase activity using 4-nitrophenyl acetate substrate [AID416126, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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32
[SID103174641]
IC50 25.647DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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33
[SID144213542]
Potency-Replicate_1 30.6379qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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34
[SID144213542]
Potency-Replicate_1 30.6379qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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35
[SID144213542]
Potency-Replicate_1 30.6379qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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36
[SID103174641]
Km 37Drug glucuronidation reaction catalyzed by human recombinant UGT1A9 [AID624637, Type: Literature]UDP-glucuronosyltransferase 1-9 [gi:29839451]
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37
[SID103174641]
EC50 44Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunits [AID219644, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:27808653]
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38
[SID103174641]
EC50 44Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunits [AID219644, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-1 [gi:23831128]
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39
[SID103174641]
EC50 44Direct activation of chloride current in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunits [AID219644, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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40
[SID144213542]
Potency-Replicate_1 48.9722qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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41
[SID144208569]
Potency-Replicate_1 54.3165qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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42
[SID144213542]
Potency-Replicate_1 54.9477qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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43
[SID144213542]
Ratio Potency (uM) 57.711qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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44
[SID144208569]
Ratio Potency (uM) 58.6496qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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45
[SID144213542]
Potency-Replicate_1 61.1306qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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46
[SID11111121]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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47
[SID11111121]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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48
[SID103174641]
Binding affinity to horse spleen apoferritin by isothermal titration calorimetry [AID496982, Type: Literature]
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49
[SID103174641]
Binding affinity to horse spleen apoferritin using 1-AMA by fluorescence competition assay [AID496983, Type: Literature]
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50
[SID103174641]
Activation of rat alpha-1-beta-2-gamma-2L expressed in HEK293 cells at 30 uM by electrophysiological assay [AID496987, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
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