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Propofol (CID 4943) - Compound BioActivity Data
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BioActivity Outcomes:
Active(91)
 
 
Inactive(1380)
 
 
Inconclusive(64)
 
 
Unspecified(271)
 
 
Top Targets:
Neur chan LBD(42)
 
 
 
7TM GPCR Srx(38)
 
 
 
 
 
NR LBD PPAR(29)
 
 
 
p450(29)
 
 
 
 
 
7TM GPCR Srsx(29)
 
 
 
 
BioAssay Types:
Confirmatory(978)
 
 
 
 
 
Screening(378)
 
 
 
Literature(302)
 
 
 
 
 
Summary(73)
 
 
 
 
BioActivity Types:
Potency(805)
 
 
 
 
 
IC50(141)
 
 
 
 
EC50(22)
 
 
 
 
Kd(4)
 
 
Ki(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1153    Data Row: 1806   Total Pages: 91   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174641]
Kd 0.23Agonist activity at GABAA assessed as enhancement of channel current [AID447577, Type: Literature]
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2
[SID103174641]
EC50 1.1Anesthetic effect on Xenopus laevis tadpole assessed as loss of spontaneous motion measured for 30 seconds after 30 mins [AID496984, Type: Literature]
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3
[SID103174641]
EC50 1.9Effective concentration required for reversible loss of righting reflex in Xenopus laevis tadpoles [AID246227, Type: Literature]
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4
[SID103174641]
EC50 1.99526Potentiation of GABA responses at human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 [AID72642, Type: Literature]
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5
[SID103174641]
EC50 1.99526Loss of righting reflex (LORR) in tadpoles was determined for anesthetic activity [AID219761, Type: Literature]
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6
[SID103174641]
EC50 1.99526Binding affinity to apoferritin by isothermal titration calorimetry [AID447576, Type: Literature]
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7
[SID103174641]
EC50 2.2Anesthetic activity in Xenopus laevis tadpoles assessed as loss of righting reflexes [AID697075, Type: Literature]
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8
[SID103174641]
EC50 2.8Anesthetic effect on Xenopus laevis tadpole assessed as loss of startle reflex after 30 mins [AID496985, Type: Literature]
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9
[SID103174641]
IC50 3.832DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]Prostaglandin G/H synthase 1 [gi:317373262]
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10
[SID103174641]
IC50 3.95Inhibition of [35S]TBPS binding to GABA-A receptor in rat cerebral cortex. [AID71848, Type: Literature]
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11
[SID103174641]
EC50 4.1GABA-modulatory action compound was evaluated on Oocytes expressing recombinant human alpha-1-beta-3-gamma-2L GABA A receptor at concentrations of >=100 micro71547, Type: Literature]
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12
[SID90341256]
Potency 4.4668qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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13
[SID103174641]
EC50 5.2Agonist activity at human alpha1beta2gamma2L GABAA receptor expressed in Xenopus oocytes assessed as potentiation of GABA-induced current response by two-electrode voltage clamp electrophysiology assay [AID697074, Type: Literature]
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14
[SID103174641]
IC50 5.499DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: confirmatory]5-hydroxytryptamine receptor 2B [gi:1168220]
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15
[SID103174641]
IC50 7.3Antagonist activity at Torpedo californica nACh receptor expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced current response [AID696815, Type: Literature]
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16
[SID103174641]
IC50 7.596DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: confirmatory]Arachidonate 15-lipoxygenase [gi:126397]
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17
[SID103174641]
EC50 8Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunits [AID219778, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-1 [gi:23831128]
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18
[SID103174641]
EC50 8Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunits [AID219778, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:27808653]
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19
[SID103174641]
EC50 8Modulation of GABA-induced chloride currents in Xenopus laevis oocytes expressing human alpha-1-beta-1-gamma-2 GABA-A receptor subunits [AID219778, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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20
[SID103174641]
IC50 8.1Inhibition of [35S]TBPS binding to GABA-A receptor rat whole brain membranes [AID71838, Type: Literature]
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