Riboflavin (CID 493570) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(24)
 
 
Inactive(148)
 
 
Inconclusive(31)
 
 
Unspecified(10)
 
 
Top Targets:
NR LBD PPAR(5)
 
 
 
NR LBD TR(4)
 
 
 
7TM GPCR Srsx(4)
 
 
 
P53(3)
 
 
NR LBD ROR li..(3)
 
 
BioAssay Types:
Confirmatory(146)
 
 
 
 
Screening(39)
 
 
 
 
Literature(15)
 
 
 
 
BioActivity Types:
Potency(109)
 
 
 
 
Kd(4)
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 201    Data Row: 213   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103566330]
Kd 0.005Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calorimetric assay [AID642884, Type: Literature]Riboflavin-binding protein [gi:132070]
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2
[SID103566330]
Kd 0.0066Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in 0.1 M phosphate buffer by isothermal titration calorimetric assay [AID642882, Type: Literature]Riboflavin-binding protein [gi:132070]
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3
[SID103566330]
Kd 0.034Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 9 in 0.1 M Tris by isothermal titration calorimetric assay [AID642880, Type: Literature]Riboflavin-binding protein [gi:132070]
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4
[SID103566330]
Kd 0.046Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 4 in 0.1 M NaAc by isothermal titration calorimetric assay [AID642881, Type: Literature]Riboflavin-binding protein [gi:132070]
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5
[SID103566330]
Ki 0.35Competitive inhibition of chicken riboflavin binding protein by surface plasmon resonance assay [AID642883, Type: Literature]Riboflavin-binding protein [gi:132070]
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6
[SID17389635]
Potency 5.9557qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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7
[SID17389635]
Potency 7.4978qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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8
[SID17389635]
Potency 7.9433qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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9
[SID17389635]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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10
[SID17389635]
Potency 31.6228qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region [AID923, Type: confirmatory]
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11
[SID17389635]
Potency 39.8107MultiTox-Fluor Cytotoxicity Assay - LYMP1-001 - Dead Cells [AID946, Type: confirmatory]
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12
[SID17389635]
Potency 39.8107MultiTox-Fluor Cytotoxicity Assay - LYMP1-003 - Dead Cells [AID961, Type: confirmatory]
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13
[SID48416517]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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14
[SID46393994]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Complexes Of Dodecin With Flavin And Flavin-Like Ligands [gi:90109102]
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15
[SID47193671]
 Counterscreen for agonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify nonselective Ga16 antagonists [AID651952, Type: screening]GNA15 gene product [Homo sapiens] [gi:156104883]
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16
[SID47193671]
 Counterscreen for agonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify nonselective agonists [AID651787, Type: screening]GNA15 gene product [Homo sapiens] [gi:156104883]
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17
[SID47193671]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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18
[SID47193671]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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19
[SID17389635]
 qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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20
[SID47193671]
 Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID651800, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
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21
[SID47193671]
 Fluorescence-based biochemical primary high throughput confirmation assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID652036, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
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22
[SID47193671]
 Fluorescence-based biochemical high throughput counterscreen assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe [AID652035, Type: screening]ALB gene product [Bos taurus] [gi:30794280]
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23
[SID47193671]
 Fluorescence-based biochemical high throughput counterscreen assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe [AID652035, Type: screening]ALB gene product [Bos taurus] [gi:30794280]
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24
[SID47193671]
 Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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25
[SID47193671]
 Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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26
[SID47193671]
 Fluorescence-based cell-based primary high throughput confirmation assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID651783, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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27
[SID47193671]
 Fluorescence-based cell-based primary high throughput confirmation assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID651783, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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28
[SID47193671]
 Counterscreen for agonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify hTAAR1 agonists that also desensitize TAAR1 receptor response. [AID651951, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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29
[SID47193671]
 Counterscreen for agonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify hTAAR1 agonists that also desensitize TAAR1 receptor response. [AID651951, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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30
[SID103566330]
 TP_TRANSPORTER: inhibition of PAH uptake (PAH: 20 uM, Riboflavin: 1000 uM) in OAT-expressing COS-7 cells [AID681019, Type: other]Solute carrier family 22 member 6 [gi:81901833]
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31
[SID17389635]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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32
[SID103566330]
 Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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33
[SID103566330]
 Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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34
[SID103566330]
 Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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35
[SID103566330]
 Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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36
[SID103566330]
 Compound was tested for the inhibition of malate dehydrogenase (MDH) at 100 uM [AID106804, Type: Literature]
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37
[SID103566330]
 Activity at androgen receptor ligand binding domain assessed as inhibition of SRC2-3 interaction at 50 uM after 2 hrs by fluorescence polarization assay [AID329525, Type: Literature]
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38
[SID103566330]
 Inhibition of chymotrypsin at 250 uM [AID52790, Type: Literature]
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39
[SID103566330]
 Inhibition of beta-lactamase at 100 uM [AID43581, Type: Literature]
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40
[SID17389635]
Potency 8.9125qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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41
[SID17389635]
Potency 19.9526qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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42
[SID17389635]
Potency 19.9526qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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43
[SID17389635]
Potency 19.9526qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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44
[SID144204364]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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45
[SID144204364]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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46
[SID144204364]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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47
[SID144204364]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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48
[SID144204364]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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49
[SID144204364]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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50
[SID144204364]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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