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Riboflavin (CID 493570) - Compound BioActivity Data
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BioActivity Outcomes:
Active(57)
 
 
Inactive(350)
 
 
Inconclusive(152)
 
 
Unspecified(10)
 
 
Top Targets:
NR LBD PPAR(31)
 
 
 
NR LBD ER(30)
 
 
 
NR LBD AR(30)
 
 
 
NR LBD GR(18)
 
 
 
NR LBD TR(16)
 
 
 
BioAssay Types:
Confirmatory(391)
 
 
 
 
Summary(87)
 
 
 
 
Screening(63)
 
 
 
 
Literature(15)
 
 
 
 
BioActivity Types:
Potency(419)
 
 
 
 
Kd(4)
 
 
Ki(1)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 317    Data Row: 569   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103566330]
Kd 0.005Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calorimetric assay [AID642884, Type: Literature]Riboflavin-binding protein [gi:132070]
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2
[SID103566330]
Kd 0.0066Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in 0.1 M phosphate buffer by isothermal titration calorimetric assay [AID642882, Type: Literature]Riboflavin-binding protein [gi:132070]
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3
[SID103566330]
Kd 0.034Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 9 in 0.1 M Tris by isothermal titration calorimetric assay [AID642880, Type: Literature]Riboflavin-binding protein [gi:132070]
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4
[SID103566330]
Kd 0.046Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 4 in 0.1 M NaAc by isothermal titration calorimetric assay [AID642881, Type: Literature]Riboflavin-binding protein [gi:132070]
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5
[SID103566330]
Ki 0.35Competitive inhibition of chicken riboflavin binding protein by surface plasmon resonance assay [AID642883, Type: Literature]Riboflavin-binding protein [gi:132070]
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6
[SID144208831]
Potency-Replicate_1 3.4027qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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7
[SID144213297]
Potency-Replicate_1 3.5803qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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8
[SID144213297]
Ratio Potency (uM) 4.01715qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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9
[SID17389635]
Potency 5.9557qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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10
[SID17389635]
Potency 7.4978qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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11
[SID17389635]
Potency 7.9433qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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12
[SID144204364]
Potency-Replicate_1 10.5909qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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13
[SID144205267]
Potency-Replicate_1 10.5909qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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14
[SID144204364]
Potency-Replicate_1 11.8832qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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15
[SID144205267]
Ratio Potency (uM) 12.3481qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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16
[SID144204364]
Ratio Potency (uM) 12.8312qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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17
[SID144204364]
Potency-Replicate_1 14.1254qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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18
[SID144204364]
Potency-Replicate_1 14.1254qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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19
[SID144205267]
Potency-Replicate_1 15.8489qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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20
[SID17389635]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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21
[SID17389635]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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22
[SID144204364]
Potency-Replicate_1 17.7828qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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23
[SID144204364]
Potency-Replicate_1 17.7828qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cell free culture [AID720686, Type: confirmatory]
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24
[SID144205267]
Potency-Replicate_1 17.7828qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cell free culture [AID720686, Type: confirmatory]
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25
[SID144205267]
Potency-Replicate_1 22.3872qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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26
[SID144205267]
Potency-Replicate_1 22.3872qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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27
[SID17389635]
Potency 31.6228qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region [AID923, Type: confirmatory]
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28
[SID144213297]
Potency-Replicate_1 31.6228qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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29
[SID144213297]
Potency-Replicate_1 35.4813qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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30
[SID144213297]
Potency-Replicate_1 35.4813qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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31
[SID144213297]
Potency-Replicate_1 35.4813qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cell free culture [AID720686, Type: confirmatory]
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32
[SID144208831]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cells [AID720675, Type: confirmatory]
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33
[SID144208831]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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34
[SID144208831]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
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35
[SID144208831]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 535 nm (green) in HepG2 cell free culture [AID720686, Type: confirmatory]
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36
[SID17389635]
Potency 39.8107MultiTox-Fluor Cytotoxicity Assay - LYMP1-003 - Dead Cells [AID961, Type: confirmatory]
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37
[SID17389635]
Potency 39.8107MultiTox-Fluor Cytotoxicity Assay - LYMP1-001 - Dead Cells [AID946, Type: confirmatory]
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38
[SID144213297]
Potency-Replicate_1 45.0731qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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39
[SID144213297]
AhR Potency (uM) 45.0731qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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40
[SID46393994]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Complexes Of Dodecin With Flavin And Flavin-Like Ligands [gi:90109102]
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41
[SID47193671]
Counterscreen for inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )]: Fluorescence polarization-based biochemical primary high throughput screening assay to identify molecules that bind to fibrin proteolytic fragment DD[E] [AID720621, Type: screening]Chain E, Fragment Double-D From Human Fibrin [gi:28373962]
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42
[SID47193671]
Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] [AID720628, Type: screening]Chain E, Fragment Double-D From Human Fibrin [gi:28373962]
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43
[SID47193671]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn7) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] [AID720508, Type: screening]Chain E, Fragment Double-D From Human Fibrin [gi:28373962]
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44
[SID47193671]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] [AID720509, Type: screening]Chain E, Fragment Double-D From Human Fibrin [gi:28373962]
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45
[SID47193671]
Fluorescence-based biochemical high throughput counterscreen assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe [AID652035, Type: screening]serum albumin precursor [Bos taurus] [gi:30794280]
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46
[SID47193671]
Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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47
[SID47193671]
Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID687036, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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48
[SID17389635]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [Homo sapiens] [gi:33946324]
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49
[SID47193671]
Counterscreen for agonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify nonselective Ga16 antagonists [AID651952, Type: screening]guanine nucleotide-binding protein subunit alpha-15 [Homo sapiens] [gi:156104883]
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50
[SID47193671]
Counterscreen for agonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify nonselective agonists [AID651787, Type: screening]guanine nucleotide-binding protein subunit alpha-15 [Homo sapiens] [gi:156104883]
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