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Promethazine (CID 4927) - Compound BioActivity Data
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BioActivity Outcomes:
Active(56)
 
 
Inactive(208)
 
 
Inconclusive(78)
 
 
Unspecified(1570)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
 
7TM GPCR Srsx(21)
 
 
 
 
p450(10)
 
 
 
NR LBD ER(9)
 
 
 
Pyr redox dim(8)
 
 
 
 
BioAssay Types:
Confirmatory(320)
 
 
 
 
 
Literature(202)
 
 
 
 
 
Summary(24)
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(218)
 
 
 
 
 
IC50(128)
 
 
 
 
Ki(1)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1822    Data Row: 1912   Total Pages: 96   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189029]
IC50 0.00287DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: confirmatory]Histamine H1 receptor [gi:547645]
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2
[SID103189029]
IC50 0.0046DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: confirmatory]Muscarinic acetylcholine receptor M5 [gi:543761]
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3
[SID103189029]
IC50 0.0054Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay [AID1054121, Type: Literature]Histamine H1 receptor [gi:547645]
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4
[SID103189029]
IC50 0.00758DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: confirmatory]Muscarinic acetylcholine receptor M4 [gi:23503039]
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5
[SID103189029]
IC50 0.012DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: confirmatory]5-hydroxytryptamine receptor 2C [gi:112816]
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6
[SID103189029]
IC50 0.014DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625151, Type: confirmatory]Muscarinic acetylcholine receptor M1 [gi:113118]
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7
[SID103189029]
IC50 0.02DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: confirmatory]Muscarinic acetylcholine receptor M3 [gi:113125]
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8
[SID103189029]
IC50 0.023Binding affinity to 5HT2A receptor (unknown origin) by radioligand binding assay [AID1054119, Type: Literature]5-hydroxytryptamine receptor 2A [gi:543727]
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9
[SID103189029]
IC50 0.035DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625152, Type: confirmatory]Muscarinic acetylcholine receptor M2 [gi:113122]
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10
[SID103189029]
IC50 0.039DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: confirmatory]Alpha-1B adrenergic receptor [gi:543734]
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11
[SID103189029]
IC50 0.053DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: confirmatory]Alpha-2B adrenergic receptor [gi:613504690]
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12
[SID103189029]
IC50 0.067DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: confirmatory]5-hydroxytryptamine receptor 2A [gi:543727]
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13
[SID103189029]
IC50 0.068DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: confirmatory]5-hydroxytryptamine receptor 2B [gi:1168220]
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14
[SID103189029]
IC50 0.079DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168244]
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15
[SID103189029]
IC50 0.1Binding affinity to dopamine D2 receptor (unknown origin) by radioligand binding assay [AID1054120, Type: Literature]D(2) dopamine receptor [gi:118206]
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16
[SID103189029]
IC50 0.183DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168243]
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17
[SID103189029]
IC50 0.287DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: confirmatory]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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18
[SID103189029]
IC50 0.4Concentration required to reduce chloroquine IC50 by 50% [AID158040, Type: Literature]
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19
[SID103189029]
IC50 0.559DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: confirmatory]D(3) dopamine receptor [gi:1169206]
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20
[SID103189029]
IC50 0.681DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: confirmatory]Alpha-2A adrenergic receptor [gi:1351829]
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