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Primidone (CID 4909) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(40)
 
 
Inactive(1871)
 
 
Inconclusive(78)
 
 
Unspecified(185)
 
 
Top Targets:
7TM GPCR Srx(49)
 
 
 
NR LBD PPAR(40)
 
 
 
7TM GPCR Srsx(40)
 
 
 
 
p450(37)
 
 
 
 
NR LBD ER(31)
 
 
 
 
BioAssay Types:
Confirmatory(1075)
 
 
 
 
 
Screening(622)
 
 
 
 
Literature(120)
 
 
 
 
Summary(73)
 
 
 
BioActivity Types:
Potency(942)
 
 
 
 
 
IC50(166)
 
 
 
EC50(11)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1351    Data Row: 2174   Total Pages: 44   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50126364]
Potency 17.7828qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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2
[SID103224166]
Sodium channel alpha subunit blocker [AID742738, Type: other]Sodium channel protein type 11 subunit alpha [gi:124053649]
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3
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:126302547]
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4
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit alpha-6 [gi:126302548]
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5
[SID103224166]
Sodium channel alpha subunit blocker [AID742738, Type: other]Sodium channel protein type 10 subunit alpha [gi:205371821]
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6
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit alpha-4 [gi:206729865]
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7
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit gamma-1 [gi:209572630]
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8
[SID103224166]
Sodium channel alpha subunit blocker [AID742738, Type: other]Sodium channel protein type 5 subunit alpha [gi:215273881]
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9
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit beta-2 [gi:292495010]
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10
[SID103224166]
Sodium channel alpha subunit blocker [AID742738, Type: other]Sodium channel protein type 4 subunit alpha [gi:292495096]
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11
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit delta [gi:59802571]
View
12
[SID26751542]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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13
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:116242488]
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14
[SID103224166]
Sodium channel alpha subunit blocker [AID742738, Type: other]Sodium channel protein type 9 subunit alpha [gi:327478559]
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15
[SID103224166]
Sodium channel alpha subunit blocker [AID742738, Type: other]Sodium channel protein type 7 subunit alpha [gi:296452902]
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16
[SID855864]
HTS to identify inhibitors of zVAD Induced Cell Death in L929 Cells. [AID1377, Type: screening]
View
17
[SID855864]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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18
[SID855864]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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19
[SID855864]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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20
[SID11111659]
qHTS Assay for Spectroscopic Profiling in Fluorescein Spectral Region [AID593, Type: other]
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21
[SID48414370]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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22
[SID48414370]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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23
[SID48414370]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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24
[SID48414370]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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25
[SID48416469]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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26
[SID855864]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors with Validation compound Set [AID588506, Type: screening]
View
27
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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28
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit alpha-3 [gi:462149]
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29
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit alpha-5 [gi:399519]
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30
[SID855864]
HTS Assay for Allosteric Antagonists of the Human D2 Dopamine Receptor: Primary Screen for Antagonists [AID485344, Type: screening]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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31
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit epsilon [gi:13124728]
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32
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit theta [gi:13959382]
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33
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit gamma-3 [gi:13959689]
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34
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit pi [gi:6016089]
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35
[SID103224166]
Sodium channel alpha subunit blocker [AID742738, Type: other]Sodium channel protein type 1 subunit alpha [gi:12644229]
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36
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit alpha-1 [gi:27808653]
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37
[SID103224166]
GABA-A receptor; anion channel positive allosteric modulator [AID742652, Type: other]Gamma-aminobutyric acid receptor subunit beta-1 [gi:23831128]
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38
[SID103224166]
Sodium channel alpha subunit blocker [AID742738, Type: other]Sodium channel protein type 2 subunit alpha [gi:25014053]
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39
[SID103224166]
Sodium channel alpha subunit blocker [AID742738, Type: other]Sodium channel protein type 3 subunit alpha [gi:25014054]
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40
[SID103224166]
Sodium channel alpha subunit blocker [AID742738, Type: other]Sodium channel protein type 8 subunit alpha [gi:34098756]
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41
[SID103224166]
IC50 DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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42
[SID103224166]
IC50 DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) [AID625259, Type: other]Estrogen receptor beta [gi:6166154]
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43
[SID103224166]
IC50 DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M4 [gi:23503039]
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44
[SID103224166]
DRUGMATRIX: Protein Tyrosine Phosphatase, PTPRC (CD45) enzyme inhibition (substrate: DiFMUP) [AID625188, Type: other]Receptor-type tyrosine-protein phosphatase C [gi:33112650]
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45
[SID103224166]
IC50 DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) [AID625145, Type: other]Cysteinyl leukotriene receptor 1 [gi:20138087]
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46
[SID103224166]
IC50 DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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47
[SID103224166]
IC50 DRUGMATRIX: Vasopressin V1A radioligand binding (ligand: [125I] PhenylacetylTyr(Me)PheGlnAsnArgProArgTyr) [AID625233, Type: other]Vasopressin V1a receptor [gi:586197]
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48
[SID103224166]
IC50 DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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49
[SID103224166]
IC50 DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) [AID625244, Type: other]Prostaglandin G/H synthase 2 [gi:3915797]
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50
[SID103224166]
IC50 DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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