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CHEMBL1352968 (CID 4880560) - Compound BioActivity Data
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BioActivity Outcomes:
Active(18)
 
 
Inactive(715)
 
 
Inconclusive(20)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(19)
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
 
KCNQ channel(10)
 
 
 
 
BioAssay Types:
Screening(517)
 
 
 
 
 
Confirmatory(214)
 
 
 
 
 
Literature(13)
 
 
 
 
BioActivity Types:
Potency(150)
 
 
 
 
 
IC50(47)
 
 
 
EC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 688    Data Row: 756   Total Pages: 38   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123050996]
IC50 1.65836SAR analysis for compounds that activate KCNQ1 potassium channels in the KCNQ1 expressing cells on automated patch clamp [AID588673, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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2
[SID160704038]
EC50 1.69Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay [AID678686, Type: Literature]
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3
[SID14745210]
Potency 7.3753Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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4
[SID14745210]
Potency 15.8489qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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5
[SID14745210]
Potency 23.1093Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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6
[SID14745210]
Potency 39.8107qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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7
[SID14745210]
Potency 39.8107qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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8
[SID14745210]
Primary Cell-based High Throughput Screening Assay for Inhibitors of Wee1 Degradation [AID1321, Type: screening]WEE1 homolog (S. pombe) [Homo sapiens] [gi:47123300]
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9
[SID14745210]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate KCNQ1 potassium channels [AID2648, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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10
[SID14745210]
Validation assay for identification of compounds that potentiate KCNQ1 potassium channels [AID493007, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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11
[SID14745210]
Secondary automated electrophysiology assay of compounds that potentiate KCNQ1 potassium channels [AID493184, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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12
[SID14745210]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 Wildtype [AID1529, Type: screening]mitogen-activated protein kinase kinase kinase 3 isoform 1 [Homo sapiens] [gi:42794767]
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13
[SID14745210]
Inhibitors of Cav3 T-type Calcium Channels: Primary Screen [AID449739, Type: screening]voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens] [gi:53832009]
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14
[SID14745210]
Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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15
[SID14745210]
Screening for Modulators of Post-Golgi Transport, Control Strain [AID738, Type: screening]
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16
[SID14745210]
Leishmania major promastigote HTS [AID1063, Type: screening]
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17
[SID14745210]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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18
[SID14745210]
CYP2C9 Assay [AID777, Type: screening]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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19
[SID14745210]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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20
[SID14745210]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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