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cyromazine (CID 47866) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(355)
 
 
Inconclusive(36)
 
 
Unspecified(134)
 
 
Top Targets:
NR LBD PPAR(29)
 
 
 
NR LBD ER(25)
 
 
 
 
NR LBD AR(24)
 
 
 
 
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(17)
 
 
 
BioAssay Types:
Confirmatory(367)
 
 
 
 
 
Summary(72)
 
 
 
 
Literature(62)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(304)
 
 
 
 
IC50(116)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 286    Data Row: 529   Total Pages: 27   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144211101]
Potency-Replicate_1 43.6412qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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2
[SID144211101]
Potency-Replicate_1 48.9662qHTS assay for small molecule activators of the heat shock response signaling pathway [AID743210, Type: confirmatory]heat shock protein beta-1 [Homo sapiens] [gi:4504517]
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3
[SID144209044]
AhR Potency (uM) 58.0045qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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4
[SID144211101]
Potency-Replicate_1 61.1306qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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5
[SID104247295]
IC50 DRUGMATRIX: Tachykinin NK1 radioligand binding (ligand: [3H] Substance P) [AID625226, Type: confirmatory]Substance-P receptor [gi:128359]
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6
[SID104247295]
IC50 DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: confirmatory]Sodium-dependent noradrenaline transporter [gi:128616]
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7
[SID104247295]
DRUGMATRIX: Neuropeptide Y Y1 radioligand binding (ligand: [125I] Peptide YY) [AID625156, Type: other]Neuropeptide Y receptor type 1 [gi:128997]
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8
[SID104247295]
IC50 DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF) [AID625168, Type: confirmatory]Platelet-activating factor receptor [gi:129557]
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9
[SID104247295]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: confirmatory]5-hydroxytryptamine receptor 1B [gi:112815]
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10
[SID104247295]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: confirmatory]5-hydroxytryptamine receptor 2C [gi:112816]
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11
[SID104247295]
IC50 DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) [AID625193, Type: confirmatory]Acetylcholinesterase [gi:113037]
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12
[SID104247295]
IC50 DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625151, Type: confirmatory]Muscarinic acetylcholine receptor M1 [gi:113118]
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13
[SID104247295]
IC50 DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625152, Type: confirmatory]Muscarinic acetylcholine receptor M2 [gi:113122]
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14
[SID104247295]
IC50 DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: confirmatory]Muscarinic acetylcholine receptor M3 [gi:113125]
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15
[SID104247295]
IC50 DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: confirmatory]Androgen receptor [gi:113832]
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16
[SID104247295]
IC50 DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) [AID625150, Type: confirmatory]Amine oxidase [flavin-containing] A [gi:113978]
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17
[SID104247295]
IC50 DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) [AID625236, Type: confirmatory]Carbonic anhydrase 2 [gi:115456]
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18
[SID104247295]
IC50 DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) [AID625235, Type: confirmatory]Cannabinoid receptor 1 [gi:115562]
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19
[SID104247295]
IC50 DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) [AID625175, Type: confirmatory]Cathepsin G [gi:115725]
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20
[SID104247295]
IC50 DRUGMATRIX: Peptidase, Matrix Metalloprotease-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625177, Type: confirmatory]Interstitial collagenase [gi:116852]
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