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8-Fluoroindolo[2,1-b]quinazoline-6,12-dione (CID 478574) - Compound BioActivity Data
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BioActivity Outcomes:
Active(82)
 
 
Inactive(500)
 
 
Inconclusive(29)
 
 
Unspecified(20)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
Death TRAILR..(12)
 
 
 
 
NB-ARC(7)
 
 
 
Peptidase C48(7)
 
 
 
BioAssay Types:
Screening(386)
 
 
 
 
 
Confirmatory(198)
 
 
 
 
 
Literature(44)
 
 
 
 
 
BioActivity Types:
Potency(129)
 
 
 
 
 
IC50(41)
 
 
 
 
EC50(12)
 
 
 
 
AC50(11)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 569    Data Row: 631   Total Pages: 32   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103753306]
ID50 0.002Antimicrobial activity against Toxoplasma gondii [AID532591, Type: Literature]
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2
[SID103753306]
IC50 0.023Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometry [AID1053471, Type: Literature]Indoleamine 2,3-dioxygenase 1 [gi:123948]
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3
[SID49667793]
AbsAC35_uM 0.0235Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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4
[SID49667793]
AbsAC35_uM 0.0251Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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5
[SID49667793]
Potency 0.0294Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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6
[SID49667793]
Potency 0.0329Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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7
[SID49667793]
Potency 0.1585Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504848, Type: confirmatory]
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8
[SID49667793]
Potency 0.1778Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504850, Type: confirmatory]
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9
[SID49667793]
Potency 0.1835qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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10
[SID49667793]
Potency 0.206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID49667793]
Potency 0.3663qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID49667793]
IC50 0.43336Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) [AID1913, Type: confirmatory]HSP90AA1 protein, partial [Homo sapiens] [gi:83318444]
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13
[SID103753306]
IC50 0.534Uncompetitive inhibition of human recombinant IDO1 using L-tryptophan as substrate [AID1053472, Type: Literature]Indoleamine 2,3-dioxygenase 1 [gi:123948]
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14
[SID49667793]
AbsAC1000_uM 0.927In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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15
[SID49667793]
IC50 0.962Dose response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using Nedd8 Protein Substrate [AID624322, Type: confirmatory]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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16
[SID49667793]
IC50 0.985Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate [AID651559, Type: confirmatory]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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17
[SID49667793]
AC50_uM 1.049MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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18
[SID49667793]
AC50_uM 1.049MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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19
[SID49667793]
AC50_uM 1.049MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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20
[SID49667793]
Potency 1.1187qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation using MMS Stimulated ELG1 [AID624249, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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