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8-Fluoroindolo[2,1-b]quinazoline-6,12-dione (CID 478574) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(67)
 
 
Inactive(494)
 
 
Inconclusive(27)
 
 
Unspecified(19)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
Death TRAILR..(12)
 
 
 
 
NB-ARC(7)
 
 
 
DUF3371(7)
 
 
 
BioAssay Types:
Screening(385)
 
 
 
 
 
Confirmatory(198)
 
 
 
 
 
Literature(21)
 
 
 
 
 
BioActivity Types:
Potency(129)
 
 
 
 
 
IC50(39)
 
 
 
 
EC50(12)
 
 
 
 
AC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 551    Data Row: 607   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103753306]
ID50 0.002Antimicrobial activity against Toxoplasma gondii [AID532591, Type: Literature]
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2
[SID49667793]
AbsAC35_uM 0.0235Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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3
[SID49667793]
AbsAC35_uM 0.0251Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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4
[SID49667793]
Potency 0.0294Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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5
[SID49667793]
Potency 0.0329Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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6
[SID49667793]
Potency 0.1585Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504848, Type: confirmatory]
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7
[SID49667793]
Potency 0.1778Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504850, Type: confirmatory]
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8
[SID49667793]
Potency 0.1835qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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9
[SID49667793]
Potency 0.206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID49667793]
Potency 0.3663qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID49667793]
IC50 0.43336Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) [AID1913, Type: confirmatory]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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12
[SID49667793]
AbsAC1000_uM 0.927In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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13
[SID49667793]
IC50 0.962Dose response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using Nedd8 Protein Substrate [AID624322, Type: confirmatory]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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14
[SID49667793]
IC50 0.985Dose-response confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using a kinetic assay with Nedd8 Protein Substrate [AID651559, Type: confirmatory]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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15
[SID49667793]
AC50_uM 1.049MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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16
[SID49667793]
AC50_uM 1.049MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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17
[SID49667793]
AC50_uM 1.049MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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18
[SID49667793]
Potency 1.1187qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation using MMS Stimulated ELG1 [AID624249, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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19
[SID49667793]
Potency 1.122qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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20
[SID49667793]
Potency 1.773qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with MMS Viability [AID624251, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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21
[SID49667793]
Potency 1.8312qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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22
[SID49667793]
Potency 2.5119qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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23
[SID49667793]
AC50_uM 2.957Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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24
[SID49667793]
AC50_uM 3.727HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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25
[SID49667793]
IC50_Mean 3.8Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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26
[SID49667793]
AC50_uM 4.387MITF Orthogonal Assay: MALME3 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-04_Inhibitor_Dose_CherryPick_Activity [AID493191, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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27
[SID49667793]
Potency 5.2119qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox [AID588382, Type: confirmatory]
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28
[SID49667793]
AC50_uM 5.5MITF Orthogonal Assay: SK-MEL-5 CTG Assay Measured in Cell-Based System Using Plate Reader - 2084-02_Inhibitor_Dose_CherryPick_Activity_Set3 [AID493240, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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29
[SID49667793]
Potency 6.5131Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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30
[SID49667793]
EC50 8.842Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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31
[SID49667793]
Potency 11.5821Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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32
[SID49667793]
Potency 19.8933HTS assay for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation [AID624248, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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33
[SID125311412]
IC50_Mean 40.9SAR analysis of small molecule inhibitors of Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588577, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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34
[SID125311412]
IC50_Mean 40.9SAR analysis of small molecule inhibitors of Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588577, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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35
[SID49667793]
AbsAC35_uM 50.01Mammalian cell toxicity counterscreen to identify toxic HSP40 inhibitor compounds in NIH3T3 cells Measured in Cell-Based System Using Plate Reader - 2120-03_Inhibitor_Dose_CherryPick_Activity_Set2 [AID624265, Type: confirmatory]
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36
[SID49667793]
IC50_Mean 60Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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37
[SID49667793]
IC50_Mean 60Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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38
[SID125311412]
IC50_Mean 67.7SAR analysis of small molecule inhibitors of Apaf-1 in a Fluorescent assay [AID588555, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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39
[SID49667793]
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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40
[SID49667793]
Single concentration confirmation of uHTS inhibitor hits of Sentrin-Specific Protease 8 using Nedd8 Protein Substrate [AID624319, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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41
[SID49667793]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_6, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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42
[SID49667793]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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43
[SID49667793]
Single concentration confirmation of uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID504614, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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44
[SID49667793]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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45
[SID49667793]
QFRET-based counterscreen for PFM18AAP inhibitors: biochemical high throughput screening assay to identify inhibitors of the Cathepsin L proteinase (CTSL1). [AID1906, Type: screening]cathepsin L1 [Homo sapiens] [gi:55958172]
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46
[SID49667793]
MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex-5 [gi:55976631]
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47
[SID49667793]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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48
[SID49667793]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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49
[SID49667793]
uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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50
[SID49667793]
Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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