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Phenylbutazone (CID 4781) - Compound BioActivity Data
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BioActivity Outcomes:
Active(53)
 
 
Inactive(1624)
 
 
Inconclusive(256)
 
 
Unspecified(1785)
 
 
Top Targets:
7TM GPCR Srx(50)
 
 
 
 
NR LBD PPAR(42)
 
 
 
7TM GPCR Srsx(41)
 
 
 
NR LBD ER(39)
 
 
 
 
 
NR LBD AR(33)
 
 
 
 
BioAssay Types:
Confirmatory(948)
 
 
 
 
 
Screening(622)
 
 
 
Literature(410)
 
 
 
 
 
Summary(89)
 
 
 
 
BioActivity Types:
Potency(871)
 
 
 
 
 
IC50(194)
 
 
 
 
 
EC50(11)
 
 
Ki(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2985    Data Row: 3718   Total Pages: 75   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103175225]
IC50 3Compound was evaluated for inhibition of Prostaglandin G/H synthase 1 [AID162309, Type: other]
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2
[SID855958]
Potency 3.2944Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID103175225]
IC50 3.79Inhibitory activity of the compound against canine COX-2 [AID220492, Type: Literature]Prostaglandin G/H synthase-2 [gi:75047671]
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4
[SID855958]
IC50_MICROM 5.3Dose Response Assay for Formylpeptide Receptor (FPR) Ligands and Dose Response Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands [AID519, Type: confirmatory]fMet-Leu-Phe receptor [Homo sapiens] [gi:4503779]
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5
[SID144203794]
Potency-Replicate_1 7.4978qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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6
[SID17389760]
Potency-Replicate_1 7.9433qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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7
[SID90341773]
Potency 10qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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8
[SID103175225]
IC50 10Inhibition of PGH synthase in tissues with lower lipid peroxide concentrations [AID155368, Type: Literature]
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9
[SID103175225]
IC50 10Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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10
[SID50104199]
Potency 11.2202qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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11
[SID50104199]
Potency 11.2202qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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12
[SID144203794]
Ratio Potency (uM) 11.607qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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13
[SID103175225]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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14
[SID103175225]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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15
[SID103175225]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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16
[SID103175225]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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17
[SID103175225]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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18
[SID104171220]
Potency 13.4591Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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19
[SID50104199]
Potency 14.1254qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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20
[SID103175225]
IC50 15Compound was tested for inhibition of prostaglandin synthetase when administered perorally [AID160905, Type: Literature]
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21
[SID103175225]
Ki 19Binding affinity towards cytochrome P450 2C9 [AID54410, Type: Literature]
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22
[SID103175225]
ED50 32.4In vivo effective dose required for antiinflammatory activity in rat adjuvant arthritis model [AID177164, Type: Literature]
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23
[SID26751573]
Potency-Replicate_1 44.6684qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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24
[SID103175225]
Cyclooxygenase inhibitor [AID742498, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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25
[SID144203793]
Ratio Potency (uM) qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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26
[SID855958]
HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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27
[SID103175225]
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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28
[SID855958]
Allosteric Antagonists for the VLA-4 Integrin [AID529, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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29
[SID103175225]
Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins [AID678715, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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30
[SID103175225]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins [AID678716, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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31
[SID103175225]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins [AID678717, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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32
[SID24424563]
Dose-Response of Allosteric Antagonists for the VLA-4 Integrin [AID702, Type: confirmatory]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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33
[SID855958]
Primary HTS Assay for Formylpeptide Receptor (FPR) Ligands and Primary HTS Counter-Screen Assay for Formylpeptide-Like-1 (FPRL1) Ligands [AID440, Type: screening]fMet-Leu-Phe receptor [Homo sapiens] [gi:4503779]
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34
[SID855958]
HTS for Estrogen Receptor-beta Coactivator Binding inhibitors [AID633, Type: screening]estrogen receptor beta isoform 1 [Homo sapiens] [gi:10835013]
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35
[SID48414314]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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36
[SID48414314]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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37
[SID48414314]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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38
[SID48414314]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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39
[SID48416423]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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40
[SID11109641]
NINDS Anticonvulsant Data (Qualitative) [AID423, Type: other]
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41
[SID855958]
Non-Nucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity HTS Single Point (MLSMR Library) [AID841, Type: screening]
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42
[SID855958]
Screen for Chemicals that Extend Yeast Lifespan [AID775, Type: screening]
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43
[SID56436656]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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44
[SID26751573]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_32, Type: Literature]
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45
[SID104171220]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_23, Type: Literature]
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46
[SID26751573]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_57, Type: Literature]
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47
[SID103175225]
Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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48
[SID103175225]
Displacement of radiolabeled warfarin from human serum albumin site 1 in phosphate buffer at pH 7.4 upto 12 uM by fluorescence spectroscopy [AID604738, Type: Literature]Serum albumin [gi:113576]
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49
[SID855958]
Secondary Calcium Response Assay for Formylpeptide Receptor (FPR) Antagonists [AID699, Type: screening]fMet-Leu-Phe receptor [Homo sapiens] [gi:4503779]
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50
[SID855958]
Assay for Formylpeptide Receptor Family Ligands: Target Formylpeptide Receptor [AID805, Type: summary]fMet-Leu-Phe receptor [Homo sapiens] [gi:4503779]
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