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Phenobarbital (CID 4763) - Compound BioActivity Data
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BioActivity Outcomes:
Active(27)
 
 
Inactive(662)
 
 
Inconclusive(34)
 
 
Unspecified(2132)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
7TM GPCR Srsx(29)
 
 
 
 
p450(26)
 
 
 
 
ABCC MRP doma..(19)
 
 
NR LBD ER(16)
 
 
 
BioAssay Types:
Literature(584)
 
 
 
 
 
Confirmatory(378)
 
 
 
 
Screening(270)
 
 
 
Summary(39)
 
 
BioActivity Types:
Potency(281)
 
 
 
 
IC50(131)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2673    Data Row: 2855   Total Pages: 143   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165722]
IC50 2.5Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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2
[SID103165722]
IC50 2.5Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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3
[SID103165722]
IC50 2.5Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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4
[SID103165722]
Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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5
[SID103165722]
Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis [AID678721, Type: Literature]
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6
[SID51087546]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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7
[SID11109645]
NINDS Anticonvulsant Data (Qualitative) [AID423, Type: other]
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8
[SID11109645]
NINDS Anticonvulsant Data (Quantitative) [AID424, Type: other]
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9
[SID48414897]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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10
[SID48414299]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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11
[SID103165722]
Anticonvulsant activity against maximal-electroshock-induced seizure in mouse at 100 mg/kg, ip after 0.5 hrs [AID290720, Type: Literature]
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12
[SID103165722]
Anticonvulsant activity against subcutaneous pentylenetetrazole-induced seizure in mouse at 30 mg/kg, ip after 0.5 hrs [AID290723, Type: Literature]
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13
[SID103165722]
Anticonvulsant activity against subcutaneous picrotoxin-induced seizure in mouse at 30 mg/kg, ip after 0.5 hrs [AID290725, Type: Literature]
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14
[SID103165722]
Anticonvulsant activity against subcutaneous picrotoxin-induced seizure in mouse at 100 mg/kg, ip after 4 hrs [AID290729, Type: Literature]
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15
[SID103165722]
Acute neurotoxicity in mouse at 100 mg/kg, ip after 0.5 hrs by rotarod test [AID290732, Type: Literature]
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16
[SID103165722]
Acute neurotoxicity in mouse at 300 mg/kg, ip after 4 hrs by rotarod test [AID290733, Type: Literature]
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17
[SID48414299]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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18
[SID48416415]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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19
[SID48414299]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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20
[SID48414299]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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