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BioActivity Data for Compound Phenobarbital (CID 4763)

BioActivity Outcomes:
Active(33)
 
 
Inactive(666)
 
 
Inconclusive(34)
 
 
Unspecified(2223)
 
 
Top Targets:
7tm 4(60)
 
 
 
 
p450(26)
 
 
 
 
ABCC MRP doma..(19)
 
 
NR LBD ER(16)
 
 
 
NR LBD AR(15)
 
 
 
 
BioAssay Types:
Literature(620)
 
 
 
 
 
Confirmatory(378)
 
 
 
 
Screening(271)
 
 
 
Summary(39)
 
 
BioAssay Categories:
In vitro(3)
 
 
 
In vivo(29)
 
 
 
Biochemical(92)
 
 
 
Toxicity(132)
 
 
 
 
 
ADME(138)
 
 
 
 
 
Cell-based(84)
 
 
 
 
Organism-base..(9)
 
 
 
BioActivity Types:
Potency(281)
 
 
 
 
IC50(131)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2774    Data Row: 2956   Total Pages: 148   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165722]
IC50 2.5Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 1 subunit alpha [gi:116447]
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2
[SID103165722]
IC50 2.5Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 2 subunit alpha [gi:116448]
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3
[SID103165722]
IC50 2.5Inhibition of [3H]BTX-B binding to neurotoxin site 2 of sodium channel of rat cerebral cortex synaptoneurosomes [AID217794, Type: Literature]Sodium channel protein type 3 subunit alpha [gi:116449]
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4
[SID103165722]
Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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5
[SID103165722]
Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis [AID678721, Type: Literature]
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6
[SID103165722]
Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins [AID678713, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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7
[SID103165722]
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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8
[SID103165722]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins [AID678716, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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9
[SID103165722]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins [AID678717, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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10
[SID103165722]
Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins [AID678715, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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11
[SID51087546]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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12
[SID103165722]
Anticonvulsant activity in Mus musculus Swiss albino (mouse) assessed as protection against subcutaneous pentylenetetrazol-induced clonic spasms at 30 mg/kg, ip after 4 hr post compound treatment [AID1085330, Type: other]
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13
[SID103165722]
Anticonvulsant activity in Mus musculus Swiss albino (mouse) assessed as protection against subcutaneous pentylenetetrazol-induced clonic spasms at 30 mg/kg, ip after 0.5 hr post compound treatment [AID1085331, Type: other]
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14
[SID103165722]
Anticonvulsant activity in albino Mus musculus (mouse) assessed as protection against subcutaneous pentylenetetrazol-induced seizures at 30 mg/kg, sc after 4 hr relative to control [AID1116954, Type: other]
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15
[SID103165722]
Anticonvulsant activity in albino Mus musculus (mouse) assessed as protection against subcutaneous pentylenetetrazol-induced seizures at 30 mg/kg, sc after 0.5 hr relative to control [AID1116958, Type: other]
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16
[SID103165722]
Anticonvulsant activity in albino Mus musculus (mouse) assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, sc after 4 hr relative to control [AID1116962, Type: other]
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17
[SID103165722]
Anticonvulsant activity in albino Mus musculus (mouse) assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, sc after 0.5 hr relative to control [AID1116966, Type: other]
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18
[SID103165722]
Mouse behavior activity was determined; D = Depressant [AID134938, Type: Literature]
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19
[SID11109645]
NINDS Anticonvulsant Data (Qualitative) [AID423, Type: other]
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20
[SID11109645]
NINDS Anticonvulsant Data (Quantitative) [AID424, Type: other]
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