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BioActivity Data for Compound Phenacetin (CID 4754)

BioActivity Outcomes:
Active(11)
 
 
Inactive(1288)
 
 
Inconclusive(72)
 
 
Unspecified(1427)
 
 
Top Targets:
7tm 4(68)
 
 
 
NR LBD PPAR(34)
 
 
 
NR LBD ER(27)
 
 
 
NR LBD AR(26)
 
 
 
p450(26)
 
 
 
 
BioAssay Types:
Confirmatory(836)
 
 
 
 
 
Screening(396)
 
 
 
Literature(150)
 
 
 
 
 
Summary(72)
 
 
 
BioAssay Categories:
In vitro(142)
 
 
 
In vivo(1231)
 
 
 
Biochemical(256)
 
 
 
Toxicity(1316)
 
 
 
 
ADME(26)
 
 
 
Cell-based(232)
 
 
 
 
 
Organism-base..(14)
 
 
 
BioActivity Types:
Potency(669)
 
 
 
 
IC50(164)
 
 
 
 
EC50(4)
 
 
AC50(3)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2282    Data Row: 2798   Total Pages: 140   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179006]
Phospholipidosis-positive literature compound observed in rat [AID540237, Type: Literature]
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2
[SID170465554]
SW480 viability from Cell TiterGlo-screen [AID1117343, Type: screening]
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3
[SID48414293]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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4
[SID48414293]
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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5
[SID48414293]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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6
[SID48414293]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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7
[SID48414293]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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8
[SID48416402]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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9
[SID50086861]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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10
[SID11112166]
Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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11
[SID11112166]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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12
[SID103179006]
IC50 200TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells [AID681160, Type: Literature]Solute carrier family 22 member 6 [gi:74762955]
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13
[SID103179006]
Ki 488TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes [AID681340, Type: Literature]Solute carrier family 22 member 6 [gi:81886651]
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14
[SID103179006]
IC50 500Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay [AID721754, Type: Literature]Multidrug and toxin extrusion protein 1 [gi:74731723]
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15
[SID103179006]
IC50 DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) [AID625227, Type: confirmatory]Substance-K receptor [gi:229462950]
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16
[SID103179006]
IC50 DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) [AID625144, Type: confirmatory]Leukotriene C4 synthase [gi:239977155]
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17
[SID103179006]
IC50 DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) [AID625229, Type: confirmatory]Thromboxane-A synthase [gi:254763392]
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18
[SID103179006]
IC50 DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: confirmatory]Beta-2 adrenergic receptor [gi:296439450]
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19
[SID103179006]
Effect on human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles relative to control [AID404304, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:308153583]
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20
[SID103179006]
DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625246, Type: other]Cytochrome P450 2A6 [gi:308153612]
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