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BioActivity Data for Compound Perphenazine (CID 4748)

BioActivity Outcomes:
Active(182)
 
 
Inactive(1240)
 
 
Inconclusive(225)
 
 
Unspecified(239)
 
 
Top Targets:
7tm 4(101)
 
 
 
 
 
p450(24)
 
 
 
 
 
Tryp SPc(17)
 
 
 
NR LBD PPAR(14)
 
 
 
Bcl-2 like(14)
 
 
BioAssay Types:
Confirmatory(827)
 
 
 
 
 
Screening(663)
 
 
 
 
Literature(240)
 
 
 
 
 
Summary(30)
 
 
 
 
BioAssay Categories:
In vitro(139)
 
 
 
 
 
In vivo(15)
 
 
 
 
 
Biochemical(297)
 
 
 
 
Toxicity(54)
 
 
 
 
 
ADME(59)
 
 
 
 
Cell-based(264)
 
 
 
 
 
Organism-base..(16)
 
 
 
BioActivity Types:
Potency(572)
 
 
 
 
 
IC50(208)
 
 
 
 
 
AC50(19)
 
 
 
EC50(16)
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1449    Data Row: 1886   Total Pages: 95   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179008]
IC50 0.0003Antagonist activity at dopamine D2 receptor (unknown origin) expressed in CHOK1 cells coexpressing Galpha15 assessed as inhibition of agonist-induced response incubated for 60 mins in incubator followed by 15 mins at room temperature by FLIPR assay [AID750642, Type: Literature]D(2) dopamine receptor [gi:118206]
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2
[SID103179008]
Ki 0.023Binding affinity towards human 5-hydroxytryptamine 7 receptor [AID6677, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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3
[SID11111646]
Potency 0.0316qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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4
[SID103179008]
IC50 0.033Inhibition of human aldehyde oxidase [AID547838, Type: Literature]Aldehyde oxidase [gi:215273968]
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5
[SID11111645]
Potency 0.1995qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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6
[SID103179008]
IC50 0.74Inhibition of rat aldehyde oxidase [AID547840, Type: Literature]Aldehyde oxidase 1 [gi:20978407]
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7
[SID90340948]
Potency 0.7943HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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8
[SID103179008]
IC50 1.4Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay [AID581672, Type: Literature]
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9
[SID144203784]
Potency 2.2387qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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10
[SID170464834]
AC50 (uM) 2.2387qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 ratio channel [AID1117305, Type: confirmatory]
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11
[SID170464834]
Ac50 2.23872qHTS Assay for Identifying Compounds that block Entry of Ebola Virus: Screen2, ratio channel [AID1117312, Type: confirmatory]
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12
[SID103179008]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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13
[SID103179008]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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14
[SID50104233]
Potency 2.5119qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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15
[SID50104233]
Potency 2.8184qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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16
[SID170464834]
AC50 (uM) 2.8184qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 blue channel [AID1117304, Type: confirmatory]
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17
[SID144203784]
Potency-Replicate_1 2.8532qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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18
[SID103179008]
IC50 3.16228Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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19
[SID50104233]
Potency 3.5481qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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20
[SID144203784]
Potency-Replicate_1 3.592qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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