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Perphenazine (CID 4748) - Compound BioActivity Data
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BioActivity Outcomes:
Active(166)
 
 
Inactive(1212)
 
 
Inconclusive(215)
 
 
Unspecified(232)
 
 
Top Targets:
7TM GPCR Srx(51)
 
 
 
 
 
7TM GPCR Srsx(50)
 
 
 
 
 
p450(24)
 
 
 
 
 
Tryp SPc(17)
 
 
 
NR LBD PPAR(14)
 
 
 
BioAssay Types:
Confirmatory(792)
 
 
 
 
 
Screening(650)
 
 
 
 
Literature(236)
 
 
 
 
 
Summary(25)
 
 
 
 
BioActivity Types:
Potency(555)
 
 
 
 
 
IC50(200)
 
 
 
 
 
EC50(16)
 
 
 
 
AC50(4)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1390    Data Row: 1825   Total Pages: 92   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179008]
IC50 0.0003Antagonist activity at dopamine D2 receptor (unknown origin) expressed in CHOK1 cells coexpressing Galpha15 assessed as inhibition of agonist-induced response incubated for 60 mins in incubator followed by 15 mins at room temperature by FLIPR assay [AID750642, Type: Literature]D(2) dopamine receptor [gi:118206]
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2
[SID103179008]
Ki 0.023Binding affinity towards human 5-hydroxytryptamine 7 receptor [AID6677, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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3
[SID11111646]
Potency 0.0316qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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4
[SID103179008]
IC50 0.033Inhibition of human aldehyde oxidase [AID547838, Type: Literature]Aldehyde oxidase [gi:215273968]
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5
[SID11111645]
Potency 0.1995qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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6
[SID103179008]
IC50 0.74Inhibition of rat aldehyde oxidase [AID547840, Type: Literature]Aldehyde oxidase 1 [gi:20978407]
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7
[SID90340948]
Potency 0.7943HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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8
[SID103179008]
IC50 1.4Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay [AID581672, Type: Literature]
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9
[SID144203784]
Potency 2.2387qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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10
[SID103179008]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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11
[SID103179008]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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12
[SID50104233]
Potency 2.5119qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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13
[SID50104233]
Potency 2.8184qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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14
[SID144203784]
Potency-Replicate_1 2.8532qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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15
[SID103179008]
IC50 3.16228Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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16
[SID50104233]
Potency 3.5481qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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17
[SID144203784]
Potency-Replicate_1 3.592qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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18
[SID144203784]
Potency-Replicate_1 3.592qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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19
[SID103179008]
IC50 3.6Inhibition of monkey aldehyde oxidase [AID547843, Type: Literature]Aldehyde oxidase 1 [gi:586830439]
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20
[SID103179008]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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