Perphenazine (CID 4748) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(145)
 
 
Inactive(1017)
 
 
Inconclusive(180)
 
 
Unspecified(210)
 
 
Top Targets:
7TM GPCR Srx(36)
 
 
 
 
 
p450(23)
 
 
 
 
 
7TM GPCR Srsx(22)
 
 
 
Tryp SPc(15)
 
 
 
alkPPc(14)
 
 
BioAssay Types:
Screening(578)
 
 
 
 
Confirmatory(548)
 
 
 
 
 
Literature(194)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(421)
 
 
 
 
 
IC50(193)
 
 
 
 
 
EC50(16)
 
 
 
 
AC50(2)
 
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1227    Data Row: 1552   Total Pages: 32   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179008]
Ki 0.023Binding affinity towards human 5-hydroxytryptamine 7 receptor [AID6677, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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2
[SID103179008]
Ki 0.023Binding affinity towards human 5-hydroxytryptamine 7 receptor [AID6677, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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3
[SID103179008]
Ki 0.023Binding affinity towards human 5-hydroxytryptamine 7 receptor [AID6677, Type: Literature]5-hydroxytryptamine receptor 7 [gi:8488960]
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4
[SID11111646]
Potency 0.0316qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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5
[SID103179008]
IC50 0.033Inhibition of human aldehyde oxidase [AID547838, Type: Literature]Aldehyde oxidas [gi:215273968]
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6
[SID11111645]
Potency 0.1995qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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7
[SID103179008]
IC50 0.74Inhibition of rat aldehyde oxidase [AID547840, Type: Literature]Aldehyde oxidas [gi:20978407]
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8
[SID90340948]
Potency 0.7943HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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9
[SID90340948]
Potency 0.7943HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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10
[SID90340948]
Potency 0.7943HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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11
[SID90340948]
Potency 0.7943HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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12
[SID103179008]
IC50 1.4Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay [AID581672, Type: Literature]
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13
[SID103179008]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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14
[SID103179008]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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15
[SID50104233]
Potency 2.5119qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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16
[SID50104233]
Potency 2.8184qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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17
[SID103179008]
IC50 3.16228Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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18
[SID50104233]
Potency 3.5481qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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19
[SID103179008]
IC50 3.6Inhibition of monkey aldehyde oxidase [AID547843, Type: Literature]Aldehyde oxidas [gi:62510320]
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20
[SID103179008]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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21
[SID103179008]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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22
[SID50104233]
Potency 3.9811qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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23
[SID50104233]
Potency 3.9811qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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24
[SID50104233]
Potency 3.9811qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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25
[SID50104233]
Potency 3.9811qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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26
[SID50104233]
Potency 3.9811qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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27
[SID103179008]
IC50 4.216DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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28
[SID103179008]
IC50 4.216DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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29
[SID103179008]
IC50 4.216DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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30
[SID103179008]
IC50 4.216DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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31
[SID103179008]
IC50 4.216DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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32
[SID50104233]
Potency 4.4668qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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33
[SID11111646]
Potency 4.5479Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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34
[SID103179008]
EC50 5Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay [AID547622, Type: Literature]
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35
[SID50104233]
Potency 5.0119qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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36
[SID50104233]
Potency 5.0119qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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37
[SID85231190]
Potency 5.2213Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
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38
[SID124881147]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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39
[SID124881147]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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40
[SID124881147]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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41
[SID103179008]
IC50 6.1Inhibition of mouse aldehyde oxidase [AID547839, Type: Literature]Aldehyde oxidase [gi:20978408]
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42
[SID103179008]
IC50 6.30957Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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43
[SID856006]
Potency 6.5733Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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44
[SID11111646]
Potency 7.208Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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45
[SID90340948]
Potency 7.3621Cytometry Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF cells [AID2668, Type: confirmatory]MTOR gene product [Homo sapiens] [gi:4826730]
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46
[SID90340948]
Potency 7.3621Cytometry Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF cells [AID2668, Type: confirmatory]MTOR gene product [Homo sapiens] [gi:4826730]
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47
[SID50104233]
Potency 7.9433qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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48
[SID50104233]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10 [AID1877, Type: confirmatory]
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49
[SID103179008]
IC50 10Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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50
[SID856006]
Potency 10qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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