Atracurium (CID 47319) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Inactive(4)
 
 
Unspecified(34)
 
 
Top Targets:
SK channel(2)
 
 
Tenui N(1)
 
 
BioAssay Types:
Literature(38)
 
 
 
Screening(1)
 
 
Confirmatory(1)
 
 
BioActivity Types:
IC50(2)
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 42    Data Row: 42   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103448799]
ED50 0.41Dose causing 50% block of muscle twitch in isolated chick biventer cervicis muscle (Decrease in baseline tension) [AID219534, Type: Literature]
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2
[SID103448799]
IC50 3Inhibition of apamin-sensitive SKCa channel of guinea-pig hepatocytes [AID241212, Type: Literature]
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3
[SID103448799]
Ki 5.9Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells [AID346945, Type: Literature]Small conductance calcium-activated potassium channel protein 3 [gi:17365967]
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4
[SID103448799]
IC50 Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique [AID346946, Type: Literature]Small conductance calcium-activated potassium channel protein 3 [gi:17365967]
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5
[SID103448799]
 Inhibition of stimulated vagus nerve-induced bradycardia in anesthetized cats [AID219378, Type: Literature]
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6
[SID103448799]
 Calculated partition coefficient (clogP) [AID21877, Type: Literature]
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7
[SID103448799]
ED50 Inhibitory potency in anesthetized cats [AID219382, Type: Literature]
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8
[SID103448799]
 Inhibition of superior cervical nerve-induced contractions of the nictitating membrane in anesthetized cats; ND means no data [AID219386, Type: Literature]
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9
[SID103448799]
 Duration (90%) measured for NMB activity in anesthetized cats [AID219389, Type: Literature]
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10
[SID103448799]
 Onset time was measured for NMB activity in anesthetized cats [AID219390, Type: Literature]
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11
[SID103448799]
 Recovery time (25-75 %) measured for NMB activity in anesthetized cats [AID219391, Type: Literature]
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12
[SID103448799]
 Volume of distribution at steady state in human after iv administration [AID540209, Type: Literature]
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13
[SID103448799]
 Clearance in human after iv administration [AID540210, Type: Literature]
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14
[SID103448799]
 Fraction unbound in human after iv administration [AID540211, Type: Literature]
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15
[SID103448799]
 Mean residence time in human after iv administration [AID540212, Type: Literature]
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16
[SID103448799]
 Half life in human after iv administration [AID540213, Type: Literature]
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17
[SID103448799]
 FDA HLAED, liver enzyme composite activity [AID588214, Type: Literature]
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18
[SID103448799]
 FDA HLAED, alkaline phosphatase increase [AID588215, Type: Literature]
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19
[SID103448799]
 FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase [AID588216, Type: Literature]
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20
[SID103448799]
 FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase [AID588217, Type: Literature]
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21
[SID103448799]
 FDA HLAED, lactate dehydrogenase (LDH) increase [AID588218, Type: Literature]
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22
[SID103448799]
 FDA HLAED, gamma-glutamyl transferase (GGT) increase [AID588219, Type: Literature]
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23
[SID103448799]
 Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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24
[SID103448799]
 FDA Liver Toxicity Knowledge Base Benchmark Dataset (LTKB-BD) drugs of no concern for DILI [AID625278, Type: Literature]
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25
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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26
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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27
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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28
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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29
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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30
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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31
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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32
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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33
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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34
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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35
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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36
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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37
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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38
[SID103448799]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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39
[SID92309177]
 A screen for compounds that inhibit liver stage malaria [AID624349, Type: other]
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40
[SID49699403]
 High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1332, Type: confirmatory]
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41
[SID92309177]
 A screen for compounds that inhibit nucleocapsid/RNA interactions in Rift Valley Fever Virus [AID651828, Type: other]Nucleoprotein [gi:127925]
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42
[SID49699403]
 Vibrio cholerae assay for pro-quorum sensing small molecules [AID686977, Type: screening]cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657203]
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