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1-(4-(4-(3-oxa-8-azabicyclo(3.2.1)octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea (CID 46947264) - Compound BioActivity Data
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BioActivity Outcomes:
Active(15)
 
 
Unspecified(7)
 
 
BioAssay Types:
Literature(22)
 
 
 
BioActivity Types:
IC50(16)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 22    Data Row: 22   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123087745]
IC50 0.00042Inhibition of mTOR [AID516655, Type: Literature]
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2
[SID123087745]
IC50 0.008Inhibition of PI3K-alpha [AID516653, Type: Literature]
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3
[SID123087745]
IC50 0.011Inhibition of PI3K-alpha H104R mutant [AID516661, Type: Literature]
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4
[SID123087745]
IC50 0.014Inhibition of PI3K-alpha E545K mutant [AID516660, Type: Literature]
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5
[SID123087745]
IC50 0.022Antiproliferative activity against human MDA-MB-361 cells [AID516656, Type: Literature]
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6
[SID123087745]
IC50 0.024Inhibition of PI3K-beta [AID516658, Type: Literature]
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7
[SID123087745]
IC50 0.029Antiproliferative activity against human PC3 cells [AID516657, Type: Literature]
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8
[SID123087745]
IC50 0.074Inhibition of PI3K-gamma [AID516654, Type: Literature]
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9
[SID123087745]
IC50 0.077Inhibition of PI3K-delta [AID516659, Type: Literature]
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10
[SID123087745]
IC50 3Inhibition of CYP2C8 [AID516670, Type: Literature]
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11
[SID123087745]
In vivo inhibition of PI3K in mouse bearing human MDA-MB-361 cells assessed as inhibition of AKT phosphorylation at 50 mg/kg, po [AID516662, Type: Literature]
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12
[SID123087745]
In vivo inhibition of mTORC1 in mouse bearing human MDA-MB-361 cells assessed as inhibition of S6K phosphorylation at 50 mg/kg, po [AID516663, Type: Literature]
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13
[SID123087745]
In vivo inhibition of mTORC1 in mouse bearing human MDA-MB-361 cells assessed as inhibition of S6 phosphorylation at 50 mg/kg, po [AID516664, Type: Literature]
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14
[SID123087745]
Induction of apoptosis in human MDA-MB-361 cells assessed as PARP cleavage after 4 hrs [AID516665, Type: Literature]
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15
[SID123087745]
Antitumor activity against human MDA-MB-361 cells xenografted in mouse assessed as inhibition tumor growth at 10 mg/kg, po qd [AID516666, Type: Literature]
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16
[SID123087745]
IC50 30Inhibition of CYP2C19 [AID516671, Type: Literature]
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17
[SID123087745]
IC50 30Inhibition of CYP2A6 [AID516672, Type: Literature]
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18
[SID123087745]
IC50 30Inhibition of CYP2B6 [AID516673, Type: Literature]
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19
[SID123087745]
IC50 30Inhibition of CYP1A2 [AID516674, Type: Literature]
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20
[SID123087745]
IC50 30Inhibition of CYP3A4 [AID516668, Type: Literature]
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