MLS003123935 (CID 46943750) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(137)
 
 
Inconclusive(5)
 
 
Top Targets:
7TM GPCR Srx(8)
 
 
7TM GPCR Srsx(4)
 
 
Peptidase M27(2)
 
 
PRK00058(2)
 
 
Nuc rec co-ac..(2)
 
 
BioAssay Types:
Screening(117)
 
 
 
Confirmatory(24)
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(24)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 147    Data Row: 147   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99456303]
Potency 10.3225qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID99456303]
Potency 10.3225qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID99456303]
Potency 10.3225qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID99456303]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID99456303]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID99456303]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID99456303]
Potency 35.4813qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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8
[SID99456303]
 HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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9
[SID99456303]
 DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity [AID651640, Type: screening]
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10
[SID99456303]
Potency 22.3872qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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11
[SID99456303]
Potency 22.3872qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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12
[SID99456303]
Potency 35.4813qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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13
[SID99456303]
 Full deck counterscreen for positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602247, Type: screening]
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14
[SID99456303]
 uHTS luminescent assay for identification of compounds that enhance the survival of human induced pluripotent stem cells when cultured as single cells [AID602274, Type: screening]
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15
[SID99456303]
 HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_Activity [AID602340, Type: screening]
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16
[SID99456303]
 Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_Activity [AID602342, Type: screening]
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17
[SID99456303]
 Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity [AID602363, Type: screening]
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18
[SID99456303]
 uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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19
[SID99456303]
 Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Activator_SinglePoint_HTS_Activity [AID623901, Type: screening]
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20
[SID99456303]
 Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
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21
[SID99456303]
 Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
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22
[SID99456303]
 HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening]
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23
[SID99456303]
 HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_SinglePoint_HTS_Activity [AID651654, Type: screening]
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24
[SID99456303]
 Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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25
[SID99456303]
 MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_Activity [AID651687, Type: screening]
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26
[SID99456303]
 Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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27
[SID99456303]
 MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_Activity [AID651723, Type: screening]
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28
[SID99456303]
 Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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29
[SID99456303]
 HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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30
[SID99456303]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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31
[SID99456303]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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32
[SID99456303]
 TRFRET-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): antagonists of MC4R [AID540295, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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33
[SID99456303]
 TRFRET-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): antagonists of MC4R [AID540295, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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34
[SID99456303]
 Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]MLLT3 gene product [Homo sapiens] [gi:156104889]
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35
[SID99456303]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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36
[SID99456303]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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37
[SID99456303]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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38
[SID99456303]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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39
[SID99456303]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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40
[SID99456303]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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41
[SID99456303]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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42
[SID99456303]
 Turbidometric Biochemical Primary HTS to identify inhibitors of Protein Disulfide Isomerase Measured in Biochemical System Using Plate Reader - 2137-01_Inhibitor_SinglePoint_HTS_Activity [AID588391, Type: screening]Prolyl 4-hydroxylase, beta polypeptide [Homo sapiens] [gi:14790033]
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43
[SID99456303]
 Turbidometric Biochemical Primary HTS to identify inhibitors of Protein Disulfide Isomerase Measured in Biochemical System Using Plate Reader - 2137-01_Inhibitor_SinglePoint_HTS_Activity [AID588391, Type: screening]Prolyl 4-hydroxylase, beta polypeptide [Homo sapiens] [gi:14790033]
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44
[SID99456303]
Potency A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression [AID624263, Type: confirmatory]Parkin [Homo sapiens] [gi:3063388]
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45
[SID99456303]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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46
[SID99456303]
 Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]KLK7 gene product [Homo sapiens] [gi:21327705]
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47
[SID99456303]
 Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]KLK7 gene product [Homo sapiens] [gi:21327705]
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48
[SID99456303]
 FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651710, Type: screening]RAD52 gene product [Homo sapiens] [gi:109637798]
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49
[SID99456303]
 qHTS Assay for Inhibitors of the CtBP/E1A Interaction [AID651724, Type: screening]CtBP interacting protein CtIP [Homo sapiens] [gi:1730321]
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50
[SID99456303]
 S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_Activity [AID652163, Type: screening]S100A4 [Homo sapiens] [gi:47496637]
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