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BioActivity Data for Compound MLS003659051 (CID 46931204)

BioActivity Outcomes:
Active(10)
 
 
Inactive(23)
 
 
Unspecified(6)
 
 
Top Targets:
NR DBD CAR(3)
 
 
FReD(2)
 
 
ZnMc TACE lik..(2)
 
 
AdoMet MTases(1)
 
 
Esterase lipa..(1)
 
 
BioAssay Types:
Screening(23)
 
 
Confirmatory(6)
 
 
Literature(4)
 
 
 
BioAssay Categories:
In vitro(3)
 
 
Biochemical(17)
 
 
Toxicity(4)
 
 
ADME(4)
 
 
 
Cell-based(12)
 
 
 
 
BioActivity Types:
IC50(3)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 38    Data Row: 39   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99309097]
IC50 2.1A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (10) [AID504827, Type: confirmatory]
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2
[SID163314168]
EC50 2.7Antiviral activity against Respiratory syncytial virus Long infected in human Hep2 cells assessed as reduction in virus-induced cytopathogenicity by Cell Titer-Glo assay [AID701507, Type: Literature]
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3
[SID99309097]
Average IC50 3A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using synthesized compounds (8) [AID504820, Type: confirmatory]
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4
[SID99309097]
IC50 7.81A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) using purified and synthesized compounds [AID488972, Type: confirmatory]
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5
[SID99309097]
CC50 29An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) using synethesized compounds (10) [AID504825, Type: confirmatory]
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6
[SID163314168]
CC50 31.8Cytotoxicity against human Hep2 cells by Cell Titer-Glo assay [AID701508, Type: Literature]
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7
[SID99309097]
Average CC50 33An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) using synethesized compounds (8) [AID504818, Type: confirmatory]
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8
[SID99309097]
CC50 38.88An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) using purified and synethesized compounds [AID488976, Type: confirmatory]
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9
[SID99309097]
A Time of Addition Assay to evaluate New Inhibitors of Respiratory syncytial virus (RSV) [AID504829, Type: other]
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10
[SID99309097]
A Plaque Reduction Assay to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) [AID504830, Type: other]
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11
[SID163314168]
Selectivity index, ratio of CC50 for human Hep2 cells to EC50 for Respiratory syncytial virus Long infected in human Hep2 cells [AID701509, Type: Literature]
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12
[SID163314168]
Antiviral activity against Respiratory syncytial virus Long infected in human Hep2 cells assessed as log reduction in virus titer at 25 uM by virus plaque reduction assay [AID701510, Type: Literature]
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13
[SID163314168]
Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 [AID1159387, Type: other]
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14
[SID163314168]
% bound to plasma by equilibrium dialysis. Compound is incubated with whole human plasma at 37C for >5hrs. Method described in B. Testa et al (Eds.), Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies, Wiley-VCH, Weinheim, 2006, pp.119-141. Experimental range 10% to 99.95% bound. [AID1159389, Type: other]
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15
[SID163314168]
Intrinsic clearance measured in human liver microsomes following incubation at 37C. Experimental range <3 to >150 microL/min/mg. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736. [AID1159394, Type: other]
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16
[SID163314168]
Intrinsic clearance measured in rat hepatocytes following incubation at 37C. Experimental range <3 to >150 microL/min/1E6 cells. Rapid Commun. Mass Spectrom. 2010, 24, 1730-1736 [AID1159395, Type: other]
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17
[SID143472250]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. [AID720582, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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18
[SID143472250]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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19
[SID143472250]
TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC) [AID720596, Type: screening]major prion protein preproprotein [Homo sapiens] [gi:4506113]
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20
[SID143472250]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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