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AGN-PC-080X2E (CID 46916265) - Compound BioActivity Data
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BioActivity Outcomes:
Active(19)
 
 
Inactive(9)
 
 
Top Targets:
Ras like GTPa..(6)
 
 
 
Rac1 like(4)
 
 
Rab7(4)
 
 
 
RhoA like(2)
 
 
GST C Mu(1)
 
 
BioAssay Types:
Confirmatory(10)
 
 
 
BioActivity Types:
EC50(10)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 15    Data Row: 28   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99381130]
EC50_MICROM 0.149SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 1 [AID588388, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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2
[SID99381130]
EC50_MICROM 0.151SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 1 [AID588387, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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3
[SID99381130]
EC50_MICROM 0.247SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 1 [AID588394, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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4
[SID99381130]
EC50_MICROM 0.376SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype, round 2 [AID588631, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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5
[SID99381130]
EC50_MICROM 0.468SAR compounds for Rab7 project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588384, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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6
[SID99381130]
EC50_MICROM 0.725SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras wildtype, round 2 [AID588630, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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7
[SID99381130]
EC50_MICROM 0.824SAR compounds tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically H-Ras activated mutant, round 2 [AID588628, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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8
[SID99381130]
Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_1, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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9
[SID99381130]
Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_2, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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10
[SID99381130]
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_5, Type: other]GTPase [Homo sapiens] [gi:407699]
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11
[SID99381130]
Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_8, Type: other]GTPase [Homo sapiens] [gi:407699]
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12
[SID99381130]
Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_4, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
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13
[SID99381130]
Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479_5, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
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14
[SID99381130]
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_3, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
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15
[SID99381130]
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_4, Type: other]Rac1 protein [Homo sapiens] [gi:8574038]
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16
[SID99381130]
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_1, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
17
[SID99381130]
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622_2, Type: other]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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18
[SID99381130]
Dose Response of round 1 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588479, Type: other]
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19
[SID99381130]
Dose Response of round 2 SAR compounds for GTPase inhibitor project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588622, Type: other]
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20
[SID99381130]
Counter screen to determine effect of SAR compounds for Rab7 project on GST-GSH binding, round 1 [AID602137, Type: other]glutathione S-transferase [Homo sapiens] [gi:31933]
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