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CHEMBL1436585 (CID 46916178) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(27)
 
 
Inactive(1)
 
 
Unspecified(4)
 
 
Top Targets:
PKc CLK1 4(9)
 
 
PKc DYRK1(7)
 
 
 
PKc CLK2(2)
 
 
PI3Kc C2 beta(1)
 
 
PI4Kc III bet..(1)
 
 
BioAssay Types:
Literature(17)
 
 
 
Confirmatory(5)
 
 
 
Summary(5)
 
 
 
BioActivity Types:
Kd(7)
 
 
IC50(6)
 
 
Potency(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 27    Data Row: 33   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99380785]
qHTS for Inhibitors of DYRK1A: Summary [AID488872, Type: summary]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
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2
[SID131277738]
Kd 0.027Binding affinity to human Dyrk1A [AID594083, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1A [gi:3219996]
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3
[SID131277738]
Kd 0.03Binding affinity to human Clk4 [AID594082, Type: Literature]Dual specificity protein kinase CLK4 [gi:34922132]
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4
[SID99380785]
Potency 0.0582Confirmation Assay for Inhibitors of Clk4 (Kinase-Glo Assay): KU probe [AID624094, Type: confirmatory]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
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5
[SID99380785]
Potency 0.0582Confirmation Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay) [AID1970, Type: confirmatory]dual specificity protein kinase CLK4 [Homo sapiens] [gi:10190706]
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6
[SID131277738]
Kd 0.072Binding affinity to human Clk1 [AID594080, Type: Literature]Dual specificity protein kinase CLK1 [gi:206729857]
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7
[SID99380785]
Potency 0.0923Assay for Inhibitors of Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A (Kinase-Glo assay) [AID2705, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
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8
[SID99380785]
Potency 0.0923Confirmation Assay for Inhibitors of Dyrk1a (Kinase-Glo Assay): KU probe [AID624093, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1 [Homo sapiens] [gi:18765758]
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9
[SID131277738]
IC50 0.093Inhibition of Dyrk1A kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594049, Type: Literature]
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10
[SID131277738]
IC50 0.141Inhibition of Clk4 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594050, Type: Literature]
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11
[SID131277738]
Kd 0.31Binding affinity to human PIP5K2C [AID594086, Type: Literature]Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [gi:317373532]
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12
[SID131277738]
Kd 0.32Binding affinity to human Clk2 [AID594081, Type: Literature]Dual specificity protein kinase CLK2 [gi:1705919]
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13
[SID131277738]
Kd 0.41Binding affinity to human PIK3C2B [AID594087, Type: Literature]Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [gi:73920246]
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14
[SID131277738]
Kd 0.43Binding affinity to human PIK4CB [AID594090, Type: Literature]Phosphatidylinositol 4-kinase beta [gi:38372507]
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15
[SID131277738]
IC50 0.522Inhibition of Clk1 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594076, Type: Literature]
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16
[SID131277738]
IC50 0.734Inhibition of Dyrk1B kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594079, Type: Literature]
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17
[SID131277738]
IC50 1.055Inhibition of Clk2 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594077, Type: Literature]
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18
[SID131277738]
IC50 3.642Inhibition of Clk3 kinase using ATP as substrate by 33P radiolabeled kinase assay [AID594078, Type: Literature]
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19
[SID99380785]
Kinase Inhibition Profile Study on Inhibitors of CDC-like Kinase 4 [AID2710, Type: other]dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform a [Homo sapiens] [gi:4758222]
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20
[SID99380785]
qHTS for Inhibitors of DYRK1B: Summary [AID488883, Type: summary]dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform a [Homo sapiens] [gi:4758222]
View