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CHEMBL1719232 (CID 46907708) - Compound BioActivity Data
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BioActivity Outcomes:
Active(15)
 
 
Inactive(1)
 
 
Unspecified(23)
 
 
Top Targets:
TUDOR(2)
 
 
Firefly Luc l..(2)
 
 
WW(1)
 
 
BioAssay Types:
Literature(35)
 
 
 
Confirmatory(4)
 
 
 
BioActivity Types:
Potency(4)
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 39    Data Row: 39   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99367988]
Potency 0.0688Confirmation Concentration-Response Assay for Enhancers of SMN2 Splice Variant Expression for Further Probe SAR [AID488832, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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2
[SID99367988]
Potency 0.7997Counterscreen Assay for Enhancers of SMN2 Splice Variant Expression: Interaction with Luciferase Reporter for Further Probe SAR [AID488838, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID134457200]
IC50 0.8Inhibition of fire fly luciferase [AID616340, Type: Literature]Luciferin 4-monooxygenase [gi:266484]
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4
[SID99367988]
Potency 4.8733Counterscreen Assay for Enhancers of SMN2 Splice Variant Expression: Modulation of SMN1 Expression for Further Probe SAR [AID488821, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:4507091]
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5
[SID134457200]
Activation of SMN expressed in HEK293 cells assessed as concentration required to reach 50% of maximum luciferase signal by SMN2-promotor driven luciferase reporter gene assay [AID616344, Type: Literature]
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6
[SID134457200]
Plasma concentration in Swiss albino mouse at 30 mg/kg, po after 24 hrs [AID616328, Type: Literature]
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7
[SID134457200]
Plasma concentration in Swiss albino mouse at 30 mg/kg, po after 12 hrs [AID616329, Type: Literature]
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8
[SID134457200]
Plasma concentration in Swiss albino mouse at 30 mg/kg, po after 8 hrs [AID616330, Type: Literature]
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9
[SID134457200]
Plasma concentration in Swiss albino mouse at 30 mg/kg, po after 4 hrs [AID616331, Type: Literature]
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10
[SID134457200]
Plasma concentration in Swiss albino mouse at 30 mg/kg, po after 2 hrs [AID616332, Type: Literature]
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11
[SID134457200]
Plasma concentration in Swiss albino mouse at 30 mg/kg, po after 1 hr [AID616333, Type: Literature]
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12
[SID134457200]
Plasma concentration in Swiss albino mouse at 30 mg/kg, po after 0.5 hrs [AID616334, Type: Literature]
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13
[SID134457200]
Plasma concentration in Swiss albino mouse at 30 mg/kg, po after 0.25 hrs [AID616335, Type: Literature]
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14
[SID134457200]
Plasma concentration in Swiss albino mouse at 30 mg/kg, po after 0.083 hrs [AID616336, Type: Literature]
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15
[SID134457200]
Cmax in plasma of Swiss albino mouse at 30 mg/kg, po [AID616274, Type: Literature]
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16
[SID134457200]
Tmax in plasma of Swiss albino mouse at 30 mg/kg, po [AID616275, Type: Literature]
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17
[SID134457200]
Drug level in Swiss albino mouse brain at 30 mg/kg, po after 24 hrs [AID616276, Type: Literature]
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18
[SID134457200]
Drug level in Swiss albino mouse brain at 30 mg/kg, po after 12 hrs [AID616277, Type: Literature]
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19
[SID134457200]
Drug level in Swiss albino mouse brain at 30 mg/kg, po after 8 hrs [AID616278, Type: Literature]
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20
[SID134457200]
Drug level in Swiss albino mouse brain at 30 mg/kg, po after 4 hrs [AID616279, Type: Literature]
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21
[SID134457200]
Drug level in Swiss albino mouse brain at 30 mg/kg, po after 2 hrs [AID616323, Type: Literature]
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22
[SID134457200]
Drug level in Swiss albino mouse brain at 30 mg/kg, po after 1 hr [AID616324, Type: Literature]
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23
[SID134457200]
Drug level in Swiss albino mouse brain at 30 mg/kg, po after 0.5 hr [AID616325, Type: Literature]
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24
[SID134457200]
Drug level in Swiss albino mouse brain at 30 mg/kg, po after 0.25 hr [AID616326, Type: Literature]
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25
[SID134457200]
Drug level in Swiss albino mouse brain at 30 mg/kg, po after 0.083 hr [AID616327, Type: Literature]
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26
[SID134457200]
Ratio of AUC in brain to AUC in plasma in Swiss albino mouse at 30 mg/kg, po [AID616265, Type: Literature]
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27
[SID134457200]
AUC (infinity) in brain of Swiss albino mouse at 30 mg/kg, po [AID616266, Type: Literature]
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28
[SID134457200]
AUClast in brain of Swiss albino mouse at 30 mg/kg, po [AID616267, Type: Literature]
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29
[SID134457200]
Half-life in brain of Swiss albino mouse at 30 mg/kg, po [AID616268, Type: Literature]
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30
[SID134457200]
Cmax in brain of Swiss albino mouse at 30 mg/kg, po [AID616269, Type: Literature]
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31
[SID134457200]
Tmax in brain of Swiss albino mouse at 30 mg/kg, po [AID616270, Type: Literature]
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32
[SID134457200]
AUClast in plasma of Swiss albino mouse at 30 mg/kg, po [AID616271, Type: Literature]
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33
[SID134457200]
AUC (infinity) in plasma of Swiss albino mouse at 30 mg/kg, po [AID616272, Type: Literature]
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34
[SID134457200]
Half-life in plasma of Swiss albino mouse at 30 mg/kg, po [AID616273, Type: Literature]
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35
[SID134457200]
Apparent permeability from basolateral side to apical side of human Caco2 cells at 10 uM [AID616337, Type: Literature]
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36
[SID134457200]
Apparent permeability from apical side to basolateral side of human Caco2 cells at 10 uM [AID616338, Type: Literature]
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37
[SID134457200]
Half-life in mouse liver microsome at 1 uM [AID616339, Type: Literature]
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38
[SID134457200]
Activation of SMN expressed in HEK293 cells assessed as rate of induction by SMN2-promotor driven luciferase reporter gene assay relative to basal level [AID616343, Type: Literature]
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39
[SID99367988]
Potency qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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