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MLS003129868 (CID 46903291) - Compound BioActivity Data
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BioActivity Outcomes:
Active(18)
 
 
Inactive(239)
 
 
Inconclusive(11)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
 
7TM GPCR Srx(7)
 
 
ZnMc TACE lik..(6)
 
 
 
PAX(5)
 
 
 
 
RasGEF(4)
 
 
BioAssay Types:
Screening(192)
 
 
 
 
Confirmatory(68)
 
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(43)
 
 
 
 
IC50(12)
 
 
 
 
AC50(11)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 232    Data Row: 272   Total Pages: 14   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144197939]
AC50_uM 4.86HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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2
[SID99358378]
Potency 9.2qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID99358378]
IC50 9.557QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10. [AID743254, Type: confirmatory]ADAM10 [Homo sapiens] [gi:2393947]
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4
[SID99358378]
Potency 25.929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID144197939]
AC50_uM 26.19SA9-PAX8: cytotoxicity NIHOVCAR3 Measured in Cell-Based System Using Plate Reader - 7054-11_Inhibitor_Dose_DryPowder_Activity [AID743044, Type: confirmatory]
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6
[SID144197939]
AC50_uM 41.63SA13 PAX8: cytotoxicity OVCAR8 Measured in Cell-Based System Using Plate Reader - 7054-15_Inhibitor_Dose_DryPowder_Activity [AID743197, Type: confirmatory]
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7
[SID144197939]
AC50_uM 62.34SA10 PAX8: cytotoxicity IGROV1 Measured in Cell-Based System Using Plate Reader - 7054-12_Inhibitor_Dose_DryPowder_Activity [AID743043, Type: confirmatory]
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8
[SID144197939]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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9
[SID99358378]
Luminescence-based cell-based high throughput confirmation assay for activators of the GAA850 frataxin (FXN) promoter [AID588351, Type: screening] [geneid:2395]
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10
[SID99358378]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening] [geneid:2395]
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11
[SID99358378]
uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651582, Type: screening]
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12
[SID99358378]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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13
[SID99358378]
Single concentration confirmation of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651629, Type: screening]
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14
[SID99358378]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. [AID720582, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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15
[SID99358378]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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16
[SID99358378]
uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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17
[SID144197939]
MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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18
[SID99358378]
uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]fatty acid synthase [Homo sapiens] [gi:41872631]
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19
[SID99358378]
IC50_1_TAG_DAPI 12.966Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_5, Type: confirmatory]
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20
[SID99358378]
IC50_2_TAG_DAPI 25Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_6, Type: confirmatory]
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