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BioActivity Data for Compound MLS003116328 (CID 46903082)

BioActivity Outcomes:
Active(4)
 
 
Inactive(218)
 
 
Inconclusive(3)
 
 
Top Targets:
7tm 4(17)
 
 
7tm 2(4)
 
 
 
RasGEF(4)
 
 
CRF-BP(4)
 
 
 
CAP ED(4)
 
 
BioAssay Types:
Screening(163)
 
 
 
Confirmatory(50)
 
 
 
 
Literature(9)
 
 
BioAssay Categories:
Organism-base..(3)
 
 
Biochemical(52)
 
 
Toxicity(2)
 
 
Cell-based(60)
 
 
BioActivity Types:
Potency(43)
 
 
 
 
IC50(5)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 205    Data Row: 225   Total Pages: 12   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99357239]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID99357239]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID99357239]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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4
[SID99357239]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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5
[SID99357239]
Potency 7.0795qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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6
[SID99357239]
IC50_Mean 47.1Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID602180, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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7
[SID99357239]
IC50_Mean 47.1Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID602180, Type: confirmatory]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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8
[SID99357239]
EC50_Mean 53Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex [AID602473, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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9
[SID99357239]
EC50_Mean 53Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex [AID602473, Type: confirmatory]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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10
[SID99357239]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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11
[SID99357239]
Potency qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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12
[SID99357239]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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13
[SID99357239]
Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
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14
[SID99357239]
uHTS luminescent assay for identification of compounds that enhance the survival of human induced pluripotent stem cells when cultured as single cells [AID602274, Type: screening]
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15
[SID99357239]
HTS for suppressors of simvastatin-induced mytoxicity in differentiated C2C12 cells Measured in Cell-Based System Using Plate Reader - 2112-01_Suppressor_SinglePoint_HTS_Activity [AID602340, Type: screening]
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16
[SID99357239]
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_Activity [AID602342, Type: screening]
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17
[SID99357239]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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18
[SID99357239]
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Activator_SinglePoint_HTS_Activity [AID623901, Type: screening]
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19
[SID99357239]
Potency qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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20
[SID99357239]
Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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