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MLS003116236 (CID 46902992) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(213)
 
 
Inconclusive(2)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
7TM GPCR Srx(7)
 
 
CAP ED(4)
 
 
RasGEF(4)
 
 
NR DBD CAR(3)
 
 
BioAssay Types:
Screening(162)
 
 
Confirmatory(49)
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(46)
 
 
 
 
IC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 205    Data Row: 217   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99357149]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID99357149]
Potency 50.1187qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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3
[SID99357149]
Potency 11.2202qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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4
[SID99357149]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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5
[SID99357149]
qHTS Assay for Inhibitors of the CtBP/E1A Interaction [AID651724, Type: screening]CtBP interacting protein CtIP [Homo sapiens] [gi:1730321]
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6
[SID99357149]
uHTS identification of SUMO1-mediated protein-protein interactions [AID602429, Type: screening]SUMO-1 [Homo sapiens] [gi:1762973]
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7
[SID99357149]
Fluorescence polarization to screen for inhibitor that competite the binding of FadD28 to bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_SinglePoint_HTS_Activity [AID588549, Type: screening]FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) [Mycobacterium tuberculosis H37Rv] [gi:1781172]
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8
[SID99357149]
Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID651800, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
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9
[SID99357149]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM10. [AID720582, Type: screening]ADAM10 [Homo sapiens] [gi:2393947]
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10
[SID99357149]
Turbidometric Biochemical Primary HTS to identify inhibitors of ERp5 Measured in Biochemical System Using Plate Reader - 7002-01_Inhibitor_SinglePoint_HTS_Activity [AID651711, Type: screening]Protein disulfide-isomerase A6 [gi:2501205]
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11
[SID99357149]
Potency qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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12
[SID99357149]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
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13
[SID99357149]
Potency A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression [AID624263, Type: confirmatory]Parkin [Homo sapiens] [gi:3063388]
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14
[SID99357149]
Potency qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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15
[SID99357149]
uHTS identification of inhibitors of cullin neddylation in a TR-FRET assay [AID651699, Type: screening]NEDD8-activating enzyme E1 regulatory subunit isoform a [Homo sapiens] [gi:4502169]
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16
[SID99357149]
uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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17
[SID99357149]
Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Antagonists [AID624463, Type: other]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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18
[SID99357149]
Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Potentiators [AID624464, Type: other]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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19
[SID99357149]
Beta-Arrestin HTS for Positive Allosteric Modulators of the Human D2 Dopamine Receptor: Agonists [AID624465, Type: other]D(2) dopamine receptor isoform long [Homo sapiens] [gi:4503385]
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20
[SID99357149]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the Galanin Receptor 3 (GalR3) [AID651719, Type: screening]galanin receptor type 3 [Homo sapiens] [gi:4503907]
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21
[SID99357149]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2) [AID602396, Type: screening]nuclear receptor subfamily 5 group A member 2 isoform 2 [Homo sapiens] [gi:4504343]
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22
[SID99357149]
TRFRET-based cell-based primary high throughput screening assay to identify inhibitors of cell surface Prion Protein (PRPC) [AID720596, Type: screening]major prion protein preproprotein [Homo sapiens] [gi:4506113]
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23
[SID99357149]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]receptor-interacting serine/threonine-protein kinase 2 [Homo sapiens] [gi:4506537]
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24
[SID99357149]
uHTS identification of inhibitors of cullin neddylation in a TR-FRET assay [AID651699, Type: screening]NEDD8-conjugating enzyme Ubc12 [Homo sapiens] [gi:4507791]
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25
[SID99357149]
uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]G-protein coupled receptor 183 [Homo sapiens] [gi:4826706]
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26
[SID99357149]
uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]matrix metalloproteinase-14 preproprotein [Homo sapiens] [gi:4826834]
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27
[SID99357149]
Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1) [AID504766, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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28
[SID99357149]
Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]nuclear receptor subfamily 0 group B member 1 [Homo sapiens] [gi:5016090]
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29
[SID99357149]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2) [AID651957, Type: screening]nuclear receptor coactivator 2 [Homo sapiens] [gi:5729858]
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30
[SID99357149]
Potency qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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31
[SID99357149]
Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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32
[SID124350662]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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33
[SID99357149]
uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651582, Type: screening]
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34
[SID99357149]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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35
[SID99357149]
DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity [AID651640, Type: screening]
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36
[SID99357149]
HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_SinglePoint_HTS_Activity [AID651654, Type: screening]
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37
[SID99357149]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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38
[SID99357149]
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_Activity [AID651687, Type: screening]
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39
[SID99357149]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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40
[SID99357149]
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_Activity [AID651723, Type: screening]
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41
[SID99357149]
Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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42
[SID99357149]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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43
[SID99357149]
7011-01_Antagonist_SinglePoint_HTS_Activity [AID720647, Type: screening]
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44
[SID99357149]
High Content Cell-Based Imaging Primary HTS to Identify Small Molecules Involved in X-Chromosome Reactivation and Reprogramming Measured in Cell-Based System Using Imaging - 7015-01_Activator_SinglePoint_HTS_Activity_Set2 [AID743238, Type: screening]
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45
[SID99357149]
Inhibition of Alexa 488-Fibronectin deposition #on AH1F cell monolayers Measured in Cell-Based System Using Plate Reader - 7059-01_Inhibitor_SinglePoint_HTS_Activity [AID743247, Type: screening]
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46
[SID99357149]
HTS for Inhibition of CaV1.3 ICDI/IQ interaction using a live-cell FRET assay Measured in Cell-Based System Using Plate Reader - 7081-01_Inhibitor_SinglePoint_HTS_Activity [AID743397, Type: screening]
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47
[SID99357149]
Wnt/Beta-catenin HTS Measured in Cell-Based System Using Plate Reader - 2161-01_Activator_SinglePoint_HTS_Activity [AID743398, Type: screening]
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48
[SID99357149]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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49
[SID99357149]
HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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50
[SID99357149]
Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_Activity [AID588436, Type: screening]
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