MLS003105970 (CID 46902908) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(24)
 
 
Inactive(153)
 
 
Inconclusive(5)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srx(8)
 
 
7TM GPCR Srsx(6)
 
 
 
Bromo SNF2L2(3)
 
 
 
Nuc rec co-ac..(2)
 
 
PRK00058(2)
 
 
BioAssay Types:
Screening(136)
 
 
 
 
Confirmatory(43)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(30)
 
 
 
 
IC50(10)
 
 
 
 
EC50(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 180    Data Row: 186   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99357045]
IC50 5.76Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630, Type: confirmatory]
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2
[SID99357045]
IC50 5.76Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_1, Type: confirmatory]
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3
[SID99357045]
Potency 10qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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4
[SID99357045]
Potency 10qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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5
[SID99357045]
Potency 11.2202qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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6
[SID99357045]
Potency 15.8489qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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7
[SID99357045]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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8
[SID99357045]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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9
[SID99357045]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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10
[SID99357045]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID99357045]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID99357045]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID99357045]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID99357045]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID99357045]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID99357045]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651608, Type: screening]Arfgap1 gene product [Rattus norvegicus] [gi:21489979]
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17
[SID99357045]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651572, Type: screening]Arfgap1 gene product [Rattus norvegicus] [gi:21489979]
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18
[SID99357045]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, i [gi:119579215]
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19
[SID99357045]
 HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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20
[SID99357045]
 uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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21
[SID99357045]
 uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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22
[SID99357045]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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23
[SID99357045]
 HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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24
[SID99357045]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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25
[SID99357045]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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26
[SID99357045]
 Luminescence-based cell-based high throughput confirmation assay for biased ligands (agonists) of the melanocortin 4 receptor (MC4R) [AID602192, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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27
[SID99357045]
 Luminescence-based cell-based high throughput confirmation assay for biased ligands (agonists) of the melanocortin 4 receptor (MC4R) [AID602192, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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28
[SID99357045]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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29
[SID99357045]
 Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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30
[SID99357045]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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31
[SID99357045]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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32
[SID99357045]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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33
[SID99357045]
 qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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34
[SID99357045]
 uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651582, Type: screening]
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35
[SID99357045]
 Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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36
[SID99357045]
 Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with compounds from Cherry Pick01 [AID651954, Type: screening]
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37
[SID99357045]
 Single concentration confirmation of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651629, Type: screening]
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38
[SID99357045]
IC50 5.585Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_2, Type: confirmatory]
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39
[SID99357045]
IC50 5.926Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_3, Type: confirmatory]
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40
[SID99357045]
IC50 23.37Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_5, Type: confirmatory]
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41
[SID99357045]
IC50 23.424Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_6, Type: confirmatory]
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42
[SID99357045]
Potency 2.2387qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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43
[SID99357045]
Potency 3.9811qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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44
[SID99357045]
Potency 15.8489qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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45
[SID99357045]
Potency 15.8489qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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46
[SID99357045]
IC50 23.4Dose Response confirmation of small molecule Triacylglycerol inhbitors in a panel assay [AID651630_4, Type: confirmatory]
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47
[SID99357045]
Potency 35.4813qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression [AID624202, Type: confirmatory]BRCA1 [Homo sapiens] [gi:1698399]
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48
[SID99357045]
Potency 35.4813qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression [AID624202, Type: confirmatory]BRCA1 [Homo sapiens] [gi:1698399]
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49
[SID99357045]
EC50 89.182Luminescence-based cell-based high throughput dose response assay for biased ligands (agonists) of the melanocortin 4 receptor (MC4R) [AID602263, Type: confirmatory]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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50
[SID99357045]
EC50 89.182Luminescence-based cell-based high throughput dose response assay for biased ligands (agonists) of the melanocortin 4 receptor (MC4R) [AID602263, Type: confirmatory]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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