4'-(pyridin-4-ylmethyl)biphenyl-3-amine (CID 46901444) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(10)
 
 
Unspecified(1)
 
 
Top Targets:
p450(8)
 
 
BioAssay Types:
Literature(11)
 
 
 
BioActivity Types:
IC50(10)
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 11    Data Row: 11   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103769220]
IC50 0.226Inhibition of human CYP17 expressed in Escherichia coli coexpressing NADPH-P450 reductase [AID491984, Type: Literature]Steroid 17-alpha-hydroxylase/17,20 lyase [gi:117283]
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2
[SID103769220]
IC50 0.226Inhibition of human CYP17 expressed in Escherichia coli [AID499539, Type: Literature]Steroid 17-alpha-hydroxylase/17,20 lyase [gi:117283]
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3
[SID103769220]
IC50 0.287Inhibition of human CYP11B1 expressed in hamster V79MZh cells [AID491985, Type: Literature]Cytochrome P450 11B1, mitochondrial [gi:215274267]
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4
[SID103769220]
IC50 0.287Inhibition of human CYP11B1 expressed in hamster fibroblast [AID499538, Type: Literature]Cytochrome P450 11B1, mitochondrial [gi:215274267]
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5
[SID103769220]
IC50 0.921Inhibition of human CYP11B2 expressed in hamster fibroblast [AID499535, Type: Literature]Cytochrome P450 11B2, mitochondrial [gi:3041666]
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6
[SID103769220]
IC50 0.921Inhibition of human CYP11B2 expressed in hamster V79MZh cells [AID491986, Type: Literature]Cytochrome P450 11B2, mitochondrial [gi:3041666]
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7
[SID103769220]
IC50 1.52Inhibition of CYP3A4 expressed in baculovirus infected insect microsomes [AID491988, Type: Literature]
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8
[SID103769220]
IC50 1.52Inhibition of recombinant CYP3A4 expressed in baculovirus-infected insect microsome [AID499536, Type: Literature]
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9
[SID103769220]
IC50 2.83Inhibition of CYP19 in human placental microsomes [AID491987, Type: Literature]Cytochrome P450 19A1 [gi:117293]
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10
[SID103769220]
IC50 2.83Inhibition of human placental CYP19 [AID499537, Type: Literature]Cytochrome P450 19A1 [gi:117293]
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11
[SID103769220]
 Selectivity ratio of IC50 for human CYP11B2 to IC50 for human CYP11B1 [AID499534, Type: Literature]
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