CHEMBL1079140 (CID 46882969) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Unspecified(8)
 
 
Top Targets:
HAD like(3)
 
 
EHN(1)
 
 
BioAssay Types:
Literature(15)
 
 
 
BioActivity Types:
IC50(10)
 
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 15    Data Row: 15   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103743656]
IC50 0.012Inhibition of human soluble epoxide hydrolase [AID470609, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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2
[SID103743656]
IC50 0.012Inhibition of human soluble epoxide hydrolase [AID470609, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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3
[SID103743656]
IC50 0.1Inhibition of potassium channel diltiazem binding site [AID470616, Type: Literature]
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4
[SID103743656]
IC50 0.119Inhibition of rat soluble epoxide hydrolase [AID470610, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:462371]
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5
[SID103743656]
IC50 0.3Inhibition of potassium channel IKr [AID470617, Type: Literature]
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6
[SID103743656]
IC50 1.3Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production [AID470611, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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7
[SID103743656]
IC50 1.3Inhibition of human soluble epoxide hydrolase in HEK293 cells assessed as DHET production [AID470611, Type: Literature]Bifunctional epoxide hydrolase 2 [gi:67476665]
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8
[SID103743656]
IC50 10Inhibition of CYP2D6 [AID470614, Type: Literature]
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9
[SID103743656]
IC50 10Inhibition of CYP3A4 [AID470615, Type: Literature]
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10
[SID103743656]
IC50 10Inhibition of CYP2C9 [AID470613, Type: Literature]
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11
[SID103743656]
IC50 10Inhibition of Nav1.5 channel [AID470618, Type: Literature]
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12
[SID103743656]
IC50 100Inhibition of human microsomal epoxide hydrolase [AID470612, Type: Literature]Epoxide hydrolase 1 [gi:123926]
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13
[SID103743656]
 Bioavailability in rat at 1 mg/kg, iv and 2 mg/kg, po [AID470619, Type: Literature]
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14
[SID103743656]
 Clearance in rat at 1 mg/kg, iv and 2 mg/kg, po [AID470620, Type: Literature]
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15
[SID103743656]
 Volume of distribution at steady state in rat at 1 mg/kg, iv and 2 mg/kg, po [AID470621, Type: Literature]
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16
[SID103743656]
 Half life in rat at 1 mg/kg, iv and 2 mg/kg, po [AID470622, Type: Literature]
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17
[SID103743656]
 Normalized AUC in rat at 2 mg/kg, po [AID470623, Type: Literature]
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