Glycyrrhizic Acid (CID 46878350) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Unspecified(201)
 
 
Top Targets:
7TM GPCR Srx(12)
 
 
7TM GPCR Srsx(9)
 
 
p450(8)
 
 
11beta-HSD1 l..(4)
 
 
 
type2 17beta..(2)
 
 
 
BioAssay Types:
Literature(57)
 
 
 
BioActivity Types:
IC50(125)
 
 
 
Ki(5)
 
 
EC50(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 208    Data Row: 208   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103735736]
IC50 0.001Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433139, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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2
[SID103735736]
EC50 0.001Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657950, Type: Literature]
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3
[SID103735736]
EC50 0.008Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657949, Type: Literature]
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4
[SID103735736]
IC50 0.008Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433138, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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5
[SID103735736]
EC50 0.01Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657948, Type: Literature]
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6
[SID103735736]
IC50 0.01Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433137, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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7
[SID103735736]
IC50 0.01Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433137, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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8
[SID103735736]
IC50 0.015Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay [AID431046, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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9
[SID103735736]
Ki 0.84TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat [AID681175, Type: other]
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10
[SID103735736]
Ki 1.91TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles from SD rat [AID679806, Type: other]
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11
[SID103735736]
Ki 6.1TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes [AID681650, Type: other]
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12
[SID103735736]
Ki 12.5TP_TRANSPORTER: inhibition of BSP uptake in Xenopus laevis oocytes [AID680384, Type: other]
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13
[SID103735736]
Ki 15.9TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes [AID680745, Type: other]
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14
[SID103735736]
IC50 82.4Hepatoprotective activity in mouse hepatocytes assessed inhibition of D-galactosamine/TNFalpha-induced cell death dosed administered before 30 mins of TNFalpha challenge measured after 18 hrs [AID359488, Type: Literature]
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15
[SID103735736]
IC50 100Inhibition of human recombinant PTP1B [AID265377, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
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16
[SID103735736]
IC50 200Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay [AID359156, Type: Literature]
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17
[SID103735736]
IC50 381Inhibition of TPA-induced EBV-early antigen activation in human Raji cells after 48hrs by indirect immunofluorescence technique [AID348191, Type: Literature]
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18
[SID103735736]
IC50 822Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release from glucose-1-phosphate [AID404873, Type: Literature]Glycogen phosphorylase, muscle form [gi:6093713]
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19
[SID103735736]
IC50 DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: other]Arachidonate 15-lipoxygenase [gi:126397]
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20
[SID103735736]
IC50 DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) [AID625173, Type: other]Angiotensin-converting enzyme [gi:2822103]
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21
[SID103735736]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) [AID625220, Type: other]5-hydroxytryptamine receptor 4 [gi:6224984]
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22
[SID103735736]
 TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, GL: 100 uM) in Xenopus laevis oocytes [AID680621, Type: other]
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23
[SID103735736]
 TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, GL: 100 uM) by Glycyrrhizic acid at a concentration of 100 u M in Xenopus laevis oocytes [AID680021, Type: other]
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24
[SID103735736]
 TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, GL: 100 uM) in Xenopus laevis oocytes [AID680383, Type: other]
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25
[SID103735736]
 Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as oxidation of [1,2,6,7-3H]cortisol to cortisone at 1 uM after 10 mins by scintillation counting [AID456097, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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26
[SID103735736]
 Hepatoprotective activity in mouse hepatocytes assessed protection against D-galactosamine/TNFalpha-induced cell death at 200 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs [AID359484, Type: Literature]
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27
[SID103735736]
 Hepatoprotective activity in mouse hepatocytes assessed protection against D-galactosamine/TNFalpha-induced cell death at 50 uM administered before 30 mins of TNFalpha challenge measured after 18 hrs [AID359487, Type: Literature]
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28
[SID103735736]
 TP_TRANSPORTER: biliary excretion in SD rat [AID679047, Type: other]
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29
[SID103735736]
 TP_TRANSPORTER: biliary excretion in EHBR rat [AID679048, Type: other]
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30
[SID103735736]
 TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, GL: 100 uM) of Glycyrrhizic acid at a concentration of 100 u M in Xenopus laevis oocytes [AID679438, Type: other]
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31
[SID103735736]
 DRUGMATRIX: Nitric Oxide Synthase, Inducible (iNOS) enzyme inhibition (substrate: L-Arginine) [AID625160, Type: other]Nitric oxide synthase, inducible [gi:266649]
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32
[SID103735736]
IC50 DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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33
[SID103735736]
IC50 DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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34
[SID103735736]
IC50 DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) [AID625208, Type: other]Aldose reductase [gi:1168407]
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35
[SID103735736]
IC50 DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: other]Androgen receptor [gi:113832]
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36
[SID103735736]
IC50 DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: other]Androgen receptor [gi:113832]
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37
[SID103735736]
IC50 DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) [AID625159, Type: other]Nitric oxide synthase, brain [gi:266646]
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38
[SID103735736]
IC50 DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) [AID625273, Type: other]Insulin receptor [gi:124531]
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39
[SID103735736]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: other]5-hydroxytryptamine receptor 1B [gi:112815]
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40
[SID103735736]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: other]5-hydroxytryptamine receptor 1B [gi:112815]
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41
[SID103735736]
IC50 DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
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42
[SID103735736]
IC50 DRUGMATRIX: Chemokine CCR2B radioligand binding (ligand: [125I] MCP-1) [AID625237, Type: other]C-C chemokine receptor type 2 [gi:1168965]
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43
[SID103735736]
 Cytotoxicity against human Raji cells assessed as cell viability at 1000 mol ratio by trypan blue staining [AID348192, Type: Literature]
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44
[SID103735736]
 Cytotoxicity against human Raji cells assessed as cell viability at 500 mol ratio by trypan blue staining [AID348193, Type: Literature]
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45
[SID103735736]
 Cytotoxicity against human Raji cells assessed as cell viability at 100 mol ratio by trypan blue staining [AID348194, Type: Literature]
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46
[SID103735736]
 Cytotoxicity against human Raji cells assessed as cell viability at 10 mol ratio by trypan blue staining [AID348195, Type: Literature]
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47
[SID103735736]
 Inhibition of DMBA-induced/TPA-promoted carcinogenesis in mouse assessed as reduction in skin papillomas bearing mouse at 85 nmol administered 1 hr before TPA treatment measured after 15 weeks [AID348197, Type: Literature]
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48
[SID103735736]
 Inhibition of DMBA-induced/TPA-promoted carcinogenesis in mouse assessed as reduction in skin papillomas bearing mouse at 85 nmol administered 1 hr before TPA treatment measured after 20 weeks [AID348198, Type: Literature]
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49
[SID103735736]
 Inhibition of DMBA-induced/TPA-promoted carcinogenesis in mouse assessed as number of skin papillomas per mouse at 85 nmol administered 1 hr before TPA treatment measured after 10 weeks [AID348199, Type: Literature]
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50
[SID103735736]
 Inhibition of DMBA-induced/TPA-promoted carcinogenesis in mouse assessed as number of skin papillomas per mouse at 85 nmol administered 1 hr before TPA treatment measured after 15 weeks [AID348200, Type: Literature]
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