T0514-5294 (CID 4683236) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(29)
 
 
Inactive(559)
 
 
Inconclusive(22)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
G-alpha(11)
 
 
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srsx(9)
 
 
Tryp SPc(6)
 
 
BioAssay Types:
Screening(408)
 
 
 
 
 
Confirmatory(185)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(131)
 
 
 
 
 
IC50(35)
 
 
 
EC50(12)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 612    Data Row: 612   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID22404620]
Potency 0.2909qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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2
[SID22404620]
IC50 0.72A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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3
[SID22404620]
IC50 1.1A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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4
[SID22404620]
CC50 2.33An HTS Cytotoxicity Screen to evaluate New Inhibitors of Respiratory Syncytial Virus (RSV) [AID2410, Type: confirmatory]
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5
[SID22404620]
Potency 11.2202Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504848, Type: confirmatory]
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6
[SID22404620]
Potency 11.2202Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504850, Type: confirmatory]
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7
[SID22404620]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID22404620]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID22404620]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID22404620]
Potency 14.581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID22404620]
Potency 14.581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID22404620]
Potency 14.581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID22404620]
Potency 15.8489qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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14
[SID22404620]
Potency 19.9526qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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15
[SID22404620]
CC50 25Vero 76 Cytoxicity Assay for VEEV Compounds [AID588719, Type: confirmatory]
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16
[SID22404620]
EC50 64.596Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast [AID1936, Type: confirmatory]
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17
[SID22404620]
EC50 114.525Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast [AID1933, Type: confirmatory]
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18
[SID22404620]
 Leishmania major promastigote HTS [AID1063, Type: screening]
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19
[SID22404620]
 Luminescence-based counterscreen assay for KLF5 inhibitors: cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1825, Type: screening]
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20
[SID22404620]
 Non-Nucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity HTS Single Point (MLSMR Library) [AID841, Type: screening]
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21
[SID22404620]
 Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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22
[SID22404620]
 Luminescence-based confirmation cell-based assay for cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1907, Type: screening]
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23
[SID93575599]
 A Titer Reduction Assay to evaluate Selected Compounds as new Inhibitors of Respiratory Syncytial Virus (RSV) [AID449732, Type: other]
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24
[SID22404620]
 A CPE Based HTS Assay for Antiviral Drug Screening Against Dengue Virus [AID540333, Type: screening]
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25
[SID22404620]
 HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening]
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26
[SID22404620]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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27
[SID22404620]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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28
[SID22404620]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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29
[SID22404620]
 qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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30
[SID22404620]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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31
[SID22404620]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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32
[SID22404620]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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33
[SID22404620]
 qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]DRD3 gene product [Homo sapiens] [gi:89191863]
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34
[SID22404620]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao. [AID1441, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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35
[SID22404620]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao. [AID1441, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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36
[SID22404620]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao. [AID1441, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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37
[SID22404620]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions. [AID1504, Type: summary]GNAO1 protein [Homo sapiens] [gi:34190601]
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38
[SID22404620]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions. [AID1504, Type: summary]GNAO1 protein [Homo sapiens] [gi:34190601]
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39
[SID22404620]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions. [AID1504, Type: summary]GNAO1 protein [Homo sapiens] [gi:34190601]
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40
[SID22404620]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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41
[SID22404620]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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42
[SID22404620]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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43
[SID22404620]
 High-throughput multiplex screening for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen [AID1326, Type: screening]ABCB1 gene product [Homo sapiens] [gi:42741659]
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44
[SID22404620]
 High-throughput multiplex screening for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen [AID1326, Type: screening]ABCB1 gene product [Homo sapiens] [gi:42741659]
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45
[SID22404620]
 High-throughput multiplex screening for ABC transporter inhibitors: specifically ABCB1 screen, ABCG2 counter-screen [AID1326, Type: screening]ABCB1 gene product [Homo sapiens] [gi:42741659]
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46
[SID22404620]
 High Content Assay for Compounds that inhibit the Assembly of the Perinucleolar Compartment [AID2417, Type: screening]polypyrimidine tract-binding protein 1 isoform a [Homo sapiens] [gi:4506243]
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47
[SID22404620]
 HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_SinglePoint_HTS_Activity [AID488896, Type: screening]Scarb1 gene product [Mus musculus] [gi:14389423]
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48
[SID22404620]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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49
[SID22404620]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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50
[SID22404620]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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