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CHEMBL2138065 (CID 46742345) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(30)
 
 
Inactive(25)
 
 
Inconclusive(1)
 
 
Top Targets:
PI-PLCc gamma(3)
 
 
 
PI-PLCc beta3(3)
 
 
 
NR DBD CAR(3)
 
 
PRP(3)
 
 
NR LBD COUP-T..(2)
 
 
 
BioAssay Types:
Screening(28)
 
 
 
Confirmatory(25)
 
 
 
 
Literature(3)
 
 
BioActivity Types:
AC50(9)
 
 
 
 
EC50(3)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 54    Data Row: 56   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID98626456]
AbsAC40_uM 0.169Hypoxia inducible pathway Measured in Cell-Based System Using Imaging - 2030-03_Activator_Dose_DryPowder_Activity_Set3 [AID493239, Type: confirmatory]
View
2
[SID98626456]
AbsAC40_uM 0.249Hypoxia inducible pathway Measured in Cell-Based System Using Imaging - 2030-03_Activator_Dose_DryPowder_Activity_Set2 [AID493225, Type: confirmatory]
View
3
[SID98626456]
AbsAC40_uM 0.393Hypoxia inducible factor pathway Measured in Cell-Based System Using Plate Reader - 2030-01_Activator_Dose_DryPowder_Activity_Set8 [AID493227, Type: confirmatory]
View
4
[SID98626456]
AbsAC40_uM 0.397HIF pathway Measured in Cell-Based System Using RT-PCR - 2030-04_Activator_Dose_DryPowder_Activity_Set2 [AID493238, Type: confirmatory]
View
5
[SID98626456]
AbsAC40_uM 0.401HIF pathway Measured in Cell-Based System Using RT-PCR - 2030-04_Activator_Dose_DryPowder_Activity_Set3 [AID493230, Type: confirmatory]
View
6
[SID111878090]
AbsAC40_uM 0.447Hypoxia inducible factor pathway Measured in Cell-Based System Using Plate Reader - 2030-01_Activator_Dose_DryPowder_Activity_Set10 [AID504588, Type: confirmatory]
View
7
[SID111878090]
AbsAC40_uM 0.546Hypoxia inducible factor pathway Measured in Cell-Based System Using Plate Reader - 2030-01_Activator_Dose_DryPowder_Activity_Set9 [AID504597, Type: confirmatory]
View
8
[SID163319697]
EC50 0.6Activation of GFP-tagged HIF1alpha expressed in human U2OS cells assessed as HIF1alpha nuclear translocation by high content imaging assay [AID691009, Type: Literature]
View
9
[SID163319697]
EC50 1.12Activation of human HIF1alpha expressed in human U2OS cells assessed as increase in VEGF expression by RT-PCR analysis [AID691010, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
View
10
[SID98626456]
AbsAC40_uM 1.131Hypoxia inducible factor pathway Measured in Cell-Based System Using Plate Reader - 2030-01_Activator_Dose_DryPowder_Activity_Set6 [AID493195, Type: confirmatory]
View
11
[SID98626456]
AbsAC500_uM 1.33Hypoxia inducible factor pathway Measured in Cell-Based System Using Plate Reader - 2030-01_Activator_Dose_DryPowder_Activity_Set7 [AID493235, Type: confirmatory]
View
12
[SID98626456]
AC50_uM 1.33ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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13
[SID98626456]
AC50_uM 1.33ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_Dose_CherryPick_Activity [AID651703, Type: confirmatory]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
View
14
[SID163319697]
EC50 1.71Activation of human HIF1alpha expressed in DFX-induced human U2OS cells incubated for 30 mins prior to DFX-induction measured after overnight incubation by luciferase reporter gene assay [AID691008, Type: Literature]Hypoxia-inducible factor 1-alpha [gi:2498017]
View
15
[SID98626456]
AbsAC40_uM 2.09Hypoxia inducible factor pathway Measured in Cell-Based System Using Plate Reader - 2030-01_Activator_Dose_DryPowder_Activity_Set4 [AID493193, Type: confirmatory]
View
16
[SID98626456]
AbsAC40_uM 2.152Hypoxia inducible factor pathway Measured in Cell-Based System Using Plate Reader - 2030-01_Activator_Dose_DryPowder_Activity_Set3 [AID493180, Type: confirmatory]
View
17
[SID98626456]
AbsAC500_uM 2.886Hypoxia inducible factor pathway Zinc Measured in Cell-Based System Using Plate Reader - 2030-05_Activator_Dose_DryPowder_Activity_Set2 [AID493234, Type: confirmatory]
View
18
[SID98626456]
AC50_uM 3.73ARNT-TACC3: counter AlphaScreen Measured in Biochemical System Using Plate Reader - 2158-02_Inhibitor_Dose_CherryPick_Activity [AID651705, Type: confirmatory]
View
19
[SID98626456]
AbsAC40_uM 20.641Hypoxia inducible factor pathway Iron Measured in Cell-Based System Using Plate Reader - 2030-06_Activator_Dose_DryPowder_Activity_Set2 [AID493237, Type: confirmatory]
View
20
[SID98626456]
AC50_uM 45.129Hypoxia inducible factor pathway Iron Measured in Cell-Based System Using Plate Reader - 2030-06_Activator_Dose_DryPowder_Toxicity [AID504331, Type: confirmatory]
View