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tolcapone (CID 4659569) - Compound BioActivity Data
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BioActivity Outcomes:
Active(30)
 
 
Inactive(90)
 
 
Inconclusive(87)
 
 
Unspecified(95)
 
 
Top Targets:
NR LBD PPAR(16)
 
 
AdoMet MTases(15)
 
 
 
NR LBD AR(14)
 
 
 
NR LBD ER(14)
 
 
 
NR LBD GR(8)
 
 
 
 
BioAssay Types:
Confirmatory(138)
 
 
 
 
Literature(107)
 
 
 
 
Summary(48)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(174)
 
 
 
 
IC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 216    Data Row: 302   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103412696]
IC50 0.0022Inhibition of Catechol O-methyltransferase activity in rat brain [AID49922, Type: Literature]
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2
[SID103412696]
IC50 0.93Inhibitory activity against COMT in rat liver [AID256793, Type: Literature]Catechol O-methyltransferase [gi:116909]
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3
[SID103412696]
IC50 2.2Inhibitory activity against COMT in rat brain [AID256794, Type: Literature]Catechol O-methyltransferase [gi:116909]
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4
[SID144212731]
Potency-Replicate_1 4.8558qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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5
[SID144212731]
Potency-Replicate_1 9.6885qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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6
[SID144212731]
Potency-Replicate_1 19.4938qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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7
[SID144206516]
Potency-Replicate_1 23.7101qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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8
[SID144206516]
Potency-Replicate_1 26.6032qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID144206516]
Ratio Potency (uM) 27.644qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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10
[SID144212731]
Potency-Replicate_1 30.6379qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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11
[SID144206516]
Potency-Replicate_1 33.4915qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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12
[SID144212731]
Potency-Replicate_1 34.6654qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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13
[SID144212731]
Potency-Replicate_1 48.5577qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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14
[SID144212731]
Potency-Replicate_1 48.9662qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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15
[SID144212731]
Potency-Replicate_1 54.4827qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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16
[SID144212731]
Potency-Replicate_1 54.4827qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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17
[SID144212731]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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18
[SID144212731]
Potency-Replicate_1 68.5896qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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19
[SID144212731]
Potency-Replicate_1 68.5896qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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20
[SID144212731]
qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743240, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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