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tolcapone (CID 4659569) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(35)
 
 
Inactive(79)
 
 
Inconclusive(92)
 
 
Unspecified(76)
 
 
Top Targets:
NR LBD PPAR(16)
 
 
AdoMet MTases(15)
 
 
 
NR LBD AR(14)
 
 
 
 
NR LBD ER(14)
 
 
 
NR LBD Fxr(8)
 
 
 
 
BioAssay Types:
Confirmatory(137)
 
 
 
 
Literature(88)
 
 
 
 
Summary(48)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(173)
 
 
 
 
IC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 196    Data Row: 282   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103412696]
IC50 0.0022Inhibition of Catechol O-methyltransferase activity in rat brain [AID49922, Type: Literature]
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2
[SID103412696]
IC50 0.93Inhibitory activity against COMT in rat liver [AID256793, Type: Literature]Catechol O-methyltransferase [gi:116909]
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3
[SID144212731]
Potency-Replicate_1 1.7229qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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4
[SID103412696]
IC50 2.2Inhibitory activity against COMT in rat brain [AID256794, Type: Literature]Catechol O-methyltransferase [gi:116909]
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5
[SID144212731]
Potency-Replicate_1 4.8558qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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6
[SID144212731]
Potency-Replicate_1 19.4938qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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7
[SID144206516]
Potency-Replicate_1 23.7101qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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8
[SID144206516]
Potency-Replicate_1 26.6032qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID144206516]
Ratio Potency (uM) 27.644qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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10
[SID170465081]
Potency-Replicate_1 29.847qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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11
[SID144206516]
Potency-Replicate_1 29.8493qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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12
[SID144206516]
Potency-Replicate_1 29.8493qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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13
[SID144212731]
Potency-Replicate_1 30.6379qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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14
[SID144212731]
Potency-Replicate_1 30.6379qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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15
[SID144206516]
Potency-Replicate_1 33.4915qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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16
[SID144212731]
Potency-Replicate_1 38.5708qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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17
[SID144212731]
Potency-Replicate_1 48.9662qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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18
[SID144212731]
Potency-Replicate_1 54.4827qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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19
[SID144212731]
Potency-Replicate_1 54.4827qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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20
[SID144212731]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line - cell viability counter screen [AID743041, Type: confirmatory]
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21
[SID144212731]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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22
[SID144212731]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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23
[SID144212731]
Potency-Replicate_1 68.5896qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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24
[SID144212731]
Potency-Replicate_1 68.5896qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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25
[SID48416644]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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26
[SID103412696]
Inhibition of COMT in Wistar rat liver homogenates assessed as metanephrine formation at 3 mg/kg, po measured after 1 hr [AID473644, Type: Literature]
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27
[SID103412696]
Inhibition of COMT in Wistar rat brain homogenates assessed as metanephrine formation at 3 mg/kg, po measured after 1 hr [AID473645, Type: Literature]
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28
[SID103412696]
Inhibition of COMT in Wistar rat liver homogenates assessed as metanephrine formation at 3 mg/kg, po measured after 3 hrs [AID473646, Type: Literature]
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29
[SID103412696]
Inhibition of COMT in Wistar rat brain homogenates assessed as metanephrine formation at 3 mg/kg, po measured after 3 hrs [AID473647, Type: Literature]
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30
[SID103412696]
Inhibition of COMT in Wistar rat plasma assessed as decrease in 3-O-methyl-L-Dopa level at 3 mg/kg, po co-administered with L-dopa and benserazide measured after 2 hrs by HPLC analysis [AID473659, Type: Literature]
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31
[SID103412696]
Inhibition of COMT in Wistar rat plasma assessed as decrease in 3-O-methyl-L-Dopa level at 3 mg/kg, po co-administered with L-dopa and benserazide measured after 7 hrs by HPLC analysis [AID473660, Type: Literature]
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32
[SID103412696]
Inhibition of COMT in Wistar rat plasma assessed as decrease in 3-O-methyl-L-Dopa level at 3 mg/kg, po co-administered with L-dopa and benserazide measured after 24 hrs by HPLC analysis [AID473661, Type: Literature]
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33
[SID144206516]
qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720725, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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34
[SID144212731]
qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743240, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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35
[SID103412696]
Catechol O-methyltransferase inhibitor [AID742923, Type: other]Catechol O-methyltransferase [gi:116907]
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36
[SID103412696]
Km 66Drug glucuronidation reaction catalyzed by human recombinant UGT1A9 [AID624637, Type: Literature]UDP-glucuronosyltransferase 1-9 [gi:29839451]
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37
[SID103412696]
Km 429Drug glucuronidation reaction catalyzed by human recombinant UGT2B15 [AID624638, Type: Literature]UDP-glucuronosyltransferase 2B15 [gi:332278237]
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38
[SID103412696]
IC50 927Inhibition of Catechol O-methyltransferase activity in rat liver [AID49923, Type: Literature]
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39
[SID103412696]
Percent inhibition of Catechol O-methyltransferase activity in rat brain at dose of 30 mg/kg determined at 0.5 hr after its administration [AID50078, Type: Literature]
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40
[SID103412696]
Percent inhibition of Catechol O-methyltransferase activity in rat brain at dose of 30 mg/kg determined at 1 hr after its administration [AID50079, Type: Literature]
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41
[SID103412696]
Percent inhibition of Catechol O-methyltransferase activity in rat brain at dose of 30 mg/kg determined at 3 hr after its administration [AID50080, Type: Literature]
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42
[SID103412696]
Percent inhibition of Catechol O-methyltransferase activity in rat brain at dose of 30 mg/kg determined at 9 hr after its administration [AID50082, Type: Literature]
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43
[SID103412696]
Percent inhibition of Catechol O-methyltransferase activity in rat liver at dose of 30 mg/kg determined at 0.5 hr after its administration [AID50083, Type: Literature]
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44
[SID103412696]
Percent inhibition of Catechol O-methyltransferase activity in rat liver at dose of 30 mg/kg determined at 1 hr after its administration [AID50084, Type: Literature]
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45
[SID103412696]
Percent inhibition of Catechol O-methyltransferase activity in rat liver at dose of 30 mg/kg determined at 3 hr after its administration [AID50085, Type: Literature]
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46
[SID103412696]
Percent inhibition of Catechol O-methyltransferase activity in rat liver at dose of 30 mg/kg determined at 6 hr after its administration [AID50086, Type: Literature]
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47
[SID103412696]
Percent inhibition of Catechol O-methyltransferase activity in rat liver at dose of 30 mg/kg determined at 9 hr after its administration [AID50088, Type: Literature]
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48
[SID103412696]
percent inhibition of Catechol O-methyltransferase activity in rat brain at dose of 30 mg/kg determined at 6 hr after its administration [AID50093, Type: Literature]
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49
[SID103412696]
In vitro clearance in dog in 1000000 cells [AID21849, Type: Literature]
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50
[SID103412696]
In vitro clearance in human in 1000000 cells [AID21851, Type: Literature]
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