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BioActivity Data for Compound tolcapone (CID 4659569)

BioActivity Outcomes:
Active(46)
 
 
Inactive(127)
 
 
Inconclusive(94)
 
 
Unspecified(96)
 
 
Top Targets:
NR LBD PPAR(16)
 
 
AdoMet MTases(15)
 
 
 
NR LBD AR(14)
 
 
 
NR LBD ER(14)
 
 
 
NR LBD VDR(8)
 
 
 
BioAssay Types:
Confirmatory(178)
 
 
 
 
Literature(109)
 
 
 
 
Summary(58)
 
 
 
 
Screening(10)
 
 
 
BioAssay Categories:
In vitro(5)
 
 
In vivo(9)
 
 
Biochemical(24)
 
 
 
 
Toxicity(34)
 
 
 
 
 
ADME(35)
 
 
Cell-based(23)
 
 
 
 
BioActivity Types:
Potency(204)
 
 
 
 
IC50(14)
 
 
 
 
AC50(12)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 261    Data Row: 363   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103412696]
IC50 0.0022Inhibition of Catechol O-methyltransferase activity in rat brain [AID49922, Type: Literature]
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2
[SID208012531]
IC50 0.0022Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]
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3
[SID208012531]
IC50 0.0022Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]
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4
[SID170465081]
IC50 0.26497GSK3B-pretreated HCT116 viability from Cell TiterGlo-IC50 [AID1117339, Type: confirmatory]
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5
[SID103412696]
IC50 0.93Inhibitory activity against COMT in rat liver [AID256793, Type: Literature]Catechol O-methyltransferase [gi:116909]
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6
[SID170465081]
IC50 1.87569RKO viability from Cell TiterGlo-IC50 [AID1117322, Type: confirmatory]
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7
[SID103412696]
IC50 2.2Inhibitory activity against COMT in rat brain [AID256794, Type: Literature]Catechol O-methyltransferase [gi:116909]
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8
[SID170465081]
IC50 2.29213HCT116 viability from Cell TiterGlo-IC50 [AID1117332, Type: confirmatory]
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9
[SID170465081]
IC50 2.50267Colo320 viability from Cell TiterGlo-IC50 [AID1117334, Type: confirmatory]
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10
[SID170465081]
IC50 4.53621SNU-C1 viability from Cell TiterGlo-IC50 [AID1117323, Type: confirmatory]
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11
[SID170465081]
IC50 4.64385SW480 viability from Cell TiterGlo-IC50 [AID1117338, Type: confirmatory]
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12
[SID144212731]
Potency-Replicate_1 4.8558qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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13
[SID144212731]
Potency-Replicate_1 9.6885qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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14
[SID144212731]
Potency-Replicate_1 19.4938qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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15
[SID144206516]
Potency-Replicate_1 23.7101qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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16
[SID144212731]
Antagonist Potency (uM) 24.3365qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway: Summary [AID1159523, Type: summary]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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17
[SID170465081]
Antagonist Potency (uM) 25.1151qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway: Summary [AID1159523, Type: summary]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
View
18
[SID170465081]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID1159521, Type: confirmatory]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
View
19
[SID144206516]
Potency-Replicate_1 26.6032qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
20
[SID144212731]
Potency-Replicate_1 27.306qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID1159521, Type: confirmatory]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
View