MLS001194674 (CID 46496200) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(5)
 
 
Inactive(425)
 
 
Inconclusive(8)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
alkPPc(4)
 
 
Peptidase C48(4)
 
 
BioAssay Types:
Screening(303)
 
 
 
 
Confirmatory(128)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(97)
 
 
 
 
 
IC50(25)
 
 
EC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 439    Data Row: 439   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49672863]
Potency 10.691qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID49672863]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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3
[SID49672863]
 Counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): luminescence-based cell-based high throughput screening assay to identify activators of the Pregnane X Receptor (PXR) [AID434939, Type: screening]nuclear receptor subfamily 1 group I member 2 isoform 1 [Homo sapiens] [gi:34398348]
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4
[SID49672863]
 Counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): luminescence-based cell-based high throughput screening assay to identify activators of the Pregnane X Receptor (PXR) [AID434939, Type: screening]nuclear receptor subfamily 1 group I member 2 isoform 1 [Homo sapiens] [gi:34398348]
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5
[SID49672863]
 Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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6
[SID49672863]
 Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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7
[SID49672863]
 Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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8
[SID49672863]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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9
[SID49672863]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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10
[SID49672863]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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11
[SID49672863]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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12
[SID49672863]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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13
[SID49672863]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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14
[SID49672863]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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15
[SID49672863]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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16
[SID49672863]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4) [AID463165, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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17
[SID49672863]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4) [AID463165, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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18
[SID49672863]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4) [AID463165, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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19
[SID49672863]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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20
[SID49672863]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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21
[SID49672863]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4) [AID463111, Type: screening]RGS4 gene product [Homo sapiens] [gi:5032039]
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22
[SID49672863]
Potency Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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23
[SID49672863]
Potency Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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24
[SID49672863]
Potency Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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25
[SID49672863]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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26
[SID49672863]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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27
[SID49672863]
Potency qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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28
[SID49672863]
IC50 Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocyste [gi:219689243]
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29
[SID49672863]
IC50 Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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30
[SID49672863]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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31
[SID49672863]
Potency qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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32
[SID49672863]
Potency qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1722, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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33
[SID49672863]
 C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_Activity [AID504423, Type: screening]LANA [Human herpesvirus 8] [gi:312275222]
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34
[SID49672863]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
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35
[SID49672863]
 TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl) [AID588664, Type: screening]ABL1 gene product [Homo sapiens] [gi:62362414]
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36
[SID49672863]
 uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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37
[SID49672863]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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38
[SID49672863]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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39
[SID49672863]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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40
[SID49672863]
 HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]ADRB2 gene product [Homo sapiens] [gi:4501969]
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41
[SID49672863]
Potency qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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42
[SID49672863]
Potency qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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43
[SID49672863]
Potency qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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44
[SID49672863]
Potency qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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45
[SID49672863]
 RNA aptamer-based HTS for inhibitors of GRK2 [AID488847, Type: screening]beta-adrenergic receptor kinase 1 [Homo sapiens] [gi:148539876]
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46
[SID49672863]
 uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID2520, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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47
[SID49672863]
 uHTS identification of small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay [AID2520, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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48
[SID49672863]
 uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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49
[SID49672863]
 uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]APLNR gene product [Homo sapiens] [gi:4885057]
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50
[SID49672863]
 Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1) [AID504766, Type: screening]NR0B1 gene product [Homo sapiens] [gi:5016090]
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