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MLS000720075 (CID 46495021) - Compound BioActivity Data
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BioActivity Outcomes:
Active(43)
 
 
Inactive(664)
 
 
Inconclusive(15)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srx(28)
 
 
 
 
7TM GPCR Srsx(17)
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(483)
 
 
 
 
Confirmatory(228)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(146)
 
 
 
 
 
IC50(54)
 
 
 
 
EC50(12)
 
 
 
AC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 659    Data Row: 729   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24811360]
Potency 3.1623Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504848, Type: confirmatory]
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2
[SID24811360]
Potency 3.5481qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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3
[SID24811360]
IC50 4.065Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor [AID463214, Type: confirmatory]type-1 angiotensin II receptor isoform 1 [Homo sapiens] [gi:4501997]
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4
[SID24811360]
Potency 4.4668qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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5
[SID24811360]
Potency 4.4668VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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6
[SID24811360]
IC50 4.93uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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7
[SID24811360]
AC50_uM 6.535MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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8
[SID24811360]
AC50_uM 6.535MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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9
[SID24811360]
AC50_uM 6.535MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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10
[SID24811360]
IC50_Mean 9.72Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2784, Type: confirmatory]apelin receptor [Homo sapiens] [gi:4885057]
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11
[SID24811360]
Potency 9.9763qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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12
[SID24811360]
IC50 9.98Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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13
[SID24811360]
Potency 10Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504850, Type: confirmatory]
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14
[SID24811360]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID24811360]
Potency 25.1189qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Giardia lamblia growth inhibition [AID2785, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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16
[SID24811360]
IC50 40.2A Cell Based Secondary Assay to Explore Compounds that Modulate Non-Replicating, Drug-tolerant Compounds in Replicating H37Rv TB of Mycobacterium tuberculosis [AID492952, Type: confirmatory]
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17
[SID24811360]
Potency 50.1187qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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18
[SID24811360]
Potency 56.2341qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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19
[SID24811360]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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20
[SID24811360]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening] [geneid:2395]
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21
[SID24811360]
Counterscreen for antagonists of the orexin 1 receptor (OX1R; HCRTR1): Homogenous time resolved fluorescence (HTRF)-based cell-based assay to identify antagonists of the parental CHO-K1 cell line [AID493232, Type: screening]
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22
[SID24811360]
Single concentration confirmation of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463112, Type: screening]
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23
[SID24811360]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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24
[SID24811360]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_1, Type: confirmatory]apelin receptor [Homo sapiens] [gi:4885057]
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25
[SID24811360]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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26
[SID24811360]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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27
[SID24811360]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]transforming acidic coiled-coil-containing protein 3 [Homo sapiens] [gi:5454102]
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28
[SID24811360]
uHTS identification of small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2521, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
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29
[SID24811360]
Single concentration confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2766, Type: screening]apelin receptor [Homo sapiens] [gi:4885057]
View
30
[SID24811360]
uHTS identification of CXCR6 Inhibitors in a B-arrestin luminescence assay [AID602244, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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31
[SID24811360]
Single concentration confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor via a luminescent beta-arrestin assay [AID602409, Type: screening]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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32
[SID24811360]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_7, Type: confirmatory]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
View
33
[SID24811360]
Primary cell-based high throughput screening assay to measure STAT1 activation [AID932, Type: screening]signal transducer and activator of transcription 1-alpha/beta isoform alpha [Homo sapiens] [gi:6274552]
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34
[SID24811360]
uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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35
[SID24811360]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_5, Type: confirmatory]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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36
[SID24811360]
HTS assay for identification of inhibitors of TNF-a-specific NF-kB induction [AID1852, Type: other]tumor necrosis factor [Homo sapiens] [gi:25952111]
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37
[SID24811360]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
View
38
[SID24811360]
qHTS of D3 Dopamine Receptor Antagonist: qHTS [AID652054, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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39
[SID24811360]
uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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40
[SID24811360]
uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463195, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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41
[SID24811360]
FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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42
[SID24811360]
Homogeneous Time Resolved Fluorescence (HTRF)-based cell-based high throughput confirmation assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID492964, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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43
[SID24811360]
Leishmania major promastigote HTS [AID1063, Type: screening]
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44
[SID24811360]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_6, Type: confirmatory]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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45
[SID24811360]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_8, Type: confirmatory]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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46
[SID24811360]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_9, Type: confirmatory]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
View
47
[SID24811360]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_10, Type: confirmatory]C-X-C chemokine receptor type 6 [Homo sapiens] [gi:5730106]
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48
[SID24811360]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_2, Type: confirmatory]apelin receptor [Homo sapiens] [gi:4885057]
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49
[SID24811360]
IC50_CXCR6_Mean Dose Response confirmation of uHTS hits from a small molecule antagonists of the CXCR6 receptor in a screening assay [AID624129_3, Type: confirmatory]apelin receptor [Homo sapiens] [gi:4885057]
View
50
[SID24811360]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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